Loi CM - Search Results

1

Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid.

Goosen TC, Bauman JN, Davis JA, Yu C, Hurst SI, Williams JA, Loi CM. Goosen TC, et al. Among authors: loi cm. Drug Metab Dispos. 2007 Aug;35(8):1315-24. doi: 10.1124/dmd.107.015230. Epub 2007 Apr 30. Drug Metab Dispos. 2007. PMID: 17470524

2

Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans.

Hurst S, Loi CM, Brodfuehrer J, El-Kattan A. Hurst S, et al. Among authors: loi cm. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):469-89. doi: 10.1517/17425225.3.4.469. Expert Opin Drug Metab Toxicol. 2007. PMID: 17696800 Review.

3

How current understanding of clearance mechanisms and pharmacodynamics of therapeutic proteins can be applied for evaluation of their drug-drug interaction potential.

Kraynov E, Martin SW, Hurst S, Fahmi OA, Dowty M, Cronenberger C, Loi CM, Kuang B, Fields O, Fountain S, Awwad M, Wang D. Kraynov E, et al. Among authors: loi cm. Drug Metab Dispos. 2011 Oct;39(10):1779-83. doi: 10.1124/dmd.111.040808. Epub 2011 Jul 18. Drug Metab Dispos. 2011. PMID: 21768274 Review.

4

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: loi cm. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377

5

Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences.

Dalvie D, Zhang C, Chen W, Smolarek T, Obach RS, Loi CM. Dalvie D, et al. Among authors: loi cm. Drug Metab Dispos. 2010 Apr;38(4):641-54. doi: 10.1124/dmd.109.030783. Epub 2009 Dec 29. Drug Metab Dispos. 2010. PMID: 20040581

6

Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein.

Yamazaki S, Loi CM, Kimoto E, Costales C, Varma MV. Yamazaki S, et al. Among authors: loi cm. Drug Metab Dispos. 2018 Aug;46(8):1200-1211. doi: 10.1124/dmd.118.080424. Epub 2018 May 8. Drug Metab Dispos. 2018. PMID: 29739809

7

Application of in-line liquid chromatography-accurate radioisotope counting-mass spectrometry (LC-ARC-MS) to evaluate metabolic profile of [3H]-mefenamic acid in rat plasma.

Lam W, Loi CM, Atherton J, Stolle W, Easter J, Mutlib A. Lam W, et al. Among authors: loi cm. Drug Metab Lett. 2007 Aug;1(3):179-88. doi: 10.2174/187231207781369771. Drug Metab Lett. 2007. PMID: 19356041

8

Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions.

Ono C, Hsyu PH, Abbas R, Loi CM, Yamazaki S. Ono C, et al. Among authors: loi cm. Drug Metab Dispos. 2017 Apr;45(4):390-398. doi: 10.1124/dmd.116.074450. Epub 2017 Feb 6. Drug Metab Dispos. 2017. PMID: 28167538

9

Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration.

Brown AP, Carlson TC, Loi CM, Graziano MJ. Brown AP, et al. Among authors: loi cm. Cancer Chemother Pharmacol. 2007 Apr;59(5):671-9. doi: 10.1007/s00280-006-0323-5. Epub 2006 Aug 31. Cancer Chemother Pharmacol. 2007. PMID: 16944149

10

Which metabolites circulate?

Loi CM, Smith DA, Dalvie D. Loi CM, et al. Drug Metab Dispos. 2013 May;41(5):933-51. doi: 10.1124/dmd.112.050278. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454828

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