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Flat-lying antibody prevents disease enhancement.
Lok SM. Lok SM. Nat Immunol. 2018 Nov;19(11):1150-1152. doi: 10.1038/s41590-018-0239-3. Nat Immunol. 2018. PMID: 30323339 No abstract available.
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
Lok SM, Kostyuchenko V, Nybakken GE, Holdaway HA, Battisti AJ, Sukupolvi-Petty S, Sedlak D, Fremont DH, Chipman PR, Roehrig JT, Diamond MS, Kuhn RJ, Rossmann MG. Lok SM, et al. Nat Struct Mol Biol. 2008 Mar;15(3):312-7. doi: 10.1038/nsmb.1382. Epub 2008 Feb 10. Nat Struct Mol Biol. 2008. PMID: 18264114
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase.
Dong H, Chang DC, Hua MH, Lim SP, Chionh YH, Hia F, Lee YH, Kukkaro P, Lok SM, Dedon PC, Shi PY. Dong H, et al. Among authors: lok sm. PLoS Pathog. 2012;8(4):e1002642. doi: 10.1371/journal.ppat.1002642. Epub 2012 Apr 5. PLoS Pathog. 2012. PMID: 22496660 Free PMC article.
The structural basis for serotype-specific neutralization of dengue virus by a human antibody.
Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, MacAry PA. Teoh EP, et al. Among authors: lok sm. Sci Transl Med. 2012 Jun 20;4(139):139ra83. doi: 10.1126/scitranslmed.3003888. Sci Transl Med. 2012. PMID: 22723463
Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1.
Zou G, Kukkaro P, Lok SM, Ng JK, Tan GK, Hanson BJ, Alonso S, MacAry PA, Shi PY. Zou G, et al. Among authors: lok sm. Antiviral Res. 2012 Sep;95(3):216-23. doi: 10.1016/j.antiviral.2012.06.010. Epub 2012 Jul 4. Antiviral Res. 2012. PMID: 22771779
The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation.
Zhang Q, Hunke C, Yau YH, Seow V, Lee S, Tanner LB, Guan XL, Wenk MR, Fibriansah G, Chew PL, Kukkaro P, Biukovic G, Shi PY, Shochat SG, Grüber G, Lok SM. Zhang Q, et al. Among authors: lok sm. J Biol Chem. 2012 Nov 23;287(48):40525-34. doi: 10.1074/jbc.M112.384446. Epub 2012 Oct 3. J Biol Chem. 2012. PMID: 23035113 Free PMC article.
Structural changes in dengue virus when exposed to a temperature of 37°C.
Fibriansah G, Ng TS, Kostyuchenko VA, Lee J, Lee S, Wang J, Lok SM. Fibriansah G, et al. Among authors: lok sm. J Virol. 2013 Jul;87(13):7585-92. doi: 10.1128/JVI.00757-13. Epub 2013 May 1. J Virol. 2013. PMID: 23637405 Free PMC article.
Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.
Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM. Kostyuchenko VA, et al. Among authors: lok sm. J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. J Virol. 2013. PMID: 23637416 Free PMC article.
Near-atomic resolution cryo-electron microscopic structure of dengue serotype 4 virus.
Kostyuchenko VA, Chew PL, Ng TS, Lok SM. Kostyuchenko VA, et al. Among authors: lok sm. J Virol. 2014 Jan;88(1):477-82. doi: 10.1128/JVI.02641-13. Epub 2013 Oct 23. J Virol. 2014. PMID: 24155405 Free PMC article.
A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface.
Fibriansah G, Tan JL, Smith SA, de Alwis AR, Ng TS, Kostyuchenko VA, Ibarra KD, Wang J, Harris E, de Silva A, Crowe JE Jr, Lok SM. Fibriansah G, et al. Among authors: lok sm. EMBO Mol Med. 2014 Mar;6(3):358-71. doi: 10.1002/emmm.201303404. Epub 2014 Jan 13. EMBO Mol Med. 2014. PMID: 24421336 Free PMC article.
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