Lokey RS[Author] - Search Results

Year	Number of Results
2000	1
2001	2
2003	1
2005	2
2006	2
2007	7
2010	4
2011	5
2012	3
2013	6
2014	1
2015	7
2016	5
2017	7
2018	4
2019	2
2020	6
2021	1

1

Conformation and Permeability: Cyclic Hexapeptide Diastereomers.

Ono S, Naylor MR, Townsend CE, Okumura C, Okada O, Lokey RS. Ono S, et al. Among authors: lokey rs. J Chem Inf Model. 2019 Jun 24;59(6):2952-2963. doi: 10.1021/acs.jcim.9b00217. Epub 2019 May 8. J Chem Inf Model. 2019. PMID: 31042375 Free PMC article.

2

Macrophage Cytological Profiling and Anti-Inflammatory Drug Discovery.

Lau TA, Bray WM, Lokey RS. Lau TA, et al. Among authors: lokey rs. Assay Drug Dev Technol. 2019 Jan;17(1):14-16. doi: 10.1089/adt.2018.894. Assay Drug Dev Technol. 2019. PMID: 30657701 Free PMC article.

3

Evidence for aggregation-independent, PrP^C-mediated Aβ cellular internalization.

Foley AR, Roseman GP, Chan K, Smart A, Finn TS, Yang K, Lokey RS, Millhauser GL, Raskatov JA. Foley AR, et al. Among authors: lokey rs. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28625-28631. doi: 10.1073/pnas.2009238117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139554

4

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.

Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Klein VG, et al. Among authors: lokey rs. ACS Med Chem Lett. 2020 Jul 30;11(9):1732-1738. doi: 10.1021/acsmedchemlett.0c00265. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32939229 Free PMC article.

5

Designing molecules to cross biological membranes.

Lokey RS, Liras J, Liras S, Jacobson MP. Lokey RS, et al. Curr Top Med Chem. 2013;13(7):775. doi: 10.2174/1568026611313070001. Curr Top Med Chem. 2013. PMID: 23578022 No abstract available.

6

Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.

Furukawa A, Schwochert J, Pye CR, Asano D, Edmondson QD, Turmon AC, Klein VG, Ono S, Okada O, Lokey RS. Furukawa A, et al. Among authors: lokey rs. Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21571-21577. doi: 10.1002/anie.202004550. Epub 2020 Sep 17. Angew Chem Int Ed Engl. 2020. PMID: 32789999 Free PMC article.

7

Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability.

Stadelmann T, Subramanian G, Menon S, Townsend CE, Lokey RS, Ebert MO, Riniker S. Stadelmann T, et al. Among authors: lokey rs. Org Biomol Chem. 2020 Sep 23;18(36):7110-7126. doi: 10.1039/d0ob01447h. Org Biomol Chem. 2020. PMID: 32902550 Free PMC article.

8

Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.

Kelly CN, Townsend CE, Jain AN, Naylor MR, Pye CR, Schwochert J, Lokey RS. Kelly CN, et al. Among authors: lokey rs. J Am Chem Soc. 2021 Jan 20;143(2):705-714. doi: 10.1021/jacs.0c06115. Epub 2020 Dec 31. J Am Chem Soc. 2021. PMID: 33381960

9

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications.

Shi Y, Bray W, Smith AJ, Zhou W, Calaoagan J, Lagisetti C, Sambucetti L, Crews P, Lokey RS, Webb TR. Shi Y, et al. Among authors: lokey rs. PLoS One. 2020 May 29;15(5):e0233672. doi: 10.1371/journal.pone.0233672. eCollection 2020. PLoS One. 2020. PMID: 32469945 Free PMC article.

10

Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets.

Naylor MR, Bockus AT, Blanco MJ, Lokey RS. Naylor MR, et al. Among authors: lokey rs. Curr Opin Chem Biol. 2017 Jun;38:141-147. doi: 10.1016/j.cbpa.2017.04.012. Epub 2017 May 29. Curr Opin Chem Biol. 2017. PMID: 28570865 Review.

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