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63 results
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Form and function in cyclic peptide natural products: a pharmacokinetic perspective.
Bockus AT, McEwen CM, Lokey RS. Bockus AT, et al. Among authors: lokey rs. Curr Top Med Chem. 2013;13(7):821-36. doi: 10.2174/1568026611313070005. Curr Top Med Chem. 2013. PMID: 23578026 Review.
Altered sequence specificity identified from a library of DNA-binding small molecules.
Guelev VM, Harting MT, Lokey RS, Iverson BL. Guelev VM, et al. Among authors: lokey rs. Chem Biol. 2000 Jan;7(1):1-8. doi: 10.1016/s1074-5521(00)00007-x. Chem Biol. 2000. PMID: 10662682
Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia.
Lokey RS. Lokey RS. Curr Opin Chem Biol. 2003 Feb;7(1):91-6. doi: 10.1016/s1367-5931(02)00002-9. Curr Opin Chem Biol. 2003. PMID: 12547432 Review.
One-bead-one-compound library of end-capped dipeptides and deconvolution by microflow NMR.
Simon RA, Schuresko L, Dendukuri N, Goers E, Murphy B, Lokey RS. Simon RA, et al. Among authors: lokey rs. J Comb Chem. 2005 Sep-Oct;7(5):697-702. doi: 10.1021/cc0500194. J Comb Chem. 2005. PMID: 16153064
Geometric diversity through permutation of backbone configuration in cyclic peptide libraries.
Perlman ZE, Bock JE, Peterson JR, Lokey RS. Perlman ZE, et al. Among authors: lokey rs. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5329-34. doi: 10.1016/j.bmcl.2005.07.089. Epub 2005 Oct 6. Bioorg Med Chem Lett. 2005. PMID: 16213707
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.
Rezai T, Yu B, Millhauser GL, Jacobson MP, Lokey RS. Rezai T, et al. Among authors: lokey rs. J Am Chem Soc. 2006 Mar 1;128(8):2510-1. doi: 10.1021/ja0563455. J Am Chem Soc. 2006. PMID: 16492015
Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides.
Rezai T, Bock JE, Zhou MV, Kalyanaraman C, Lokey RS, Jacobson MP. Rezai T, et al. Among authors: lokey rs. J Am Chem Soc. 2006 Nov 1;128(43):14073-80. doi: 10.1021/ja063076p. J Am Chem Soc. 2006. PMID: 17061890
Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.
Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Gassner NC, et al. Among authors: lokey rs. J Nat Prod. 2007 Mar;70(3):383-90. doi: 10.1021/np060555t. Epub 2007 Feb 10. J Nat Prod. 2007. PMID: 17291044 Free PMC article.
A practical solid-phase synthesis of Glu7-phalloidin and entry into fluorescent F-actin-binding reagents.
Schuresko LA, Lokey RS. Schuresko LA, et al. Among authors: lokey rs. Angew Chem Int Ed Engl. 2007;46(19):3547-9. doi: 10.1002/anie.200700017. Angew Chem Int Ed Engl. 2007. PMID: 17385816 No abstract available.
Uncovering genetic relationships using small molecules that selectively target yeast cell cycle mutants.
Nehil MT, Tamble CM, Combs DJ, Kellogg DR, Lokey RS. Nehil MT, et al. Among authors: lokey rs. Chem Biol Drug Des. 2007 Apr;69(4):258-64. doi: 10.1111/j.1747-0285.2007.00496.x. Chem Biol Drug Des. 2007. PMID: 17461973
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