Lokey RS - Search Results

1

Form and function in cyclic peptide natural products: a pharmacokinetic perspective.

Bockus AT, McEwen CM, Lokey RS. Bockus AT, et al. Among authors: lokey rs. Curr Top Med Chem. 2013;13(7):821-36. doi: 10.2174/1568026611313070005. Curr Top Med Chem. 2013. PMID: 23578026 Review.

2

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

Rezai T, Yu B, Millhauser GL, Jacobson MP, Lokey RS. Rezai T, et al. Among authors: lokey rs. J Am Chem Soc. 2006 Mar 1;128(8):2510-1. doi: 10.1021/ja0563455. J Am Chem Soc. 2006. PMID: 16492015

3

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides.

Rezai T, Bock JE, Zhou MV, Kalyanaraman C, Lokey RS, Jacobson MP. Rezai T, et al. Among authors: lokey rs. J Am Chem Soc. 2006 Nov 1;128(43):14073-80. doi: 10.1021/ja063076p. J Am Chem Soc. 2006. PMID: 17061890

4

New structures and bioactivity properties of jasplakinolide (jaspamide) analogues from marine sponges.

Robinson SJ, Morinaka BI, Amagata T, Tenney K, Bray WM, Gassner NC, Lokey RS, Crews P. Robinson SJ, et al. Among authors: lokey rs. J Med Chem. 2010 Feb 25;53(4):1651-61. doi: 10.1021/jm9013554. J Med Chem. 2010. PMID: 20121114 Free PMC article.

5

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.

White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, Jacobson MP, Lokey RS. White TR, et al. Among authors: lokey rs. Nat Chem Biol. 2011 Sep 25;7(11):810-7. doi: 10.1038/nchembio.664. Nat Chem Biol. 2011. PMID: 21946276 Free PMC article.

6

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.

Schulze CJ, Bray WM, Woerhmann MH, Stuart J, Lokey RS, Linington RG. Schulze CJ, et al. Among authors: lokey rs. Chem Biol. 2013 Feb 21;20(2):285-95. doi: 10.1016/j.chembiol.2012.12.007. Chem Biol. 2013. PMID: 23438757 Free PMC article.

7

Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides.

Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Schwochert J, et al. Among authors: lokey rs. Org Lett. 2014 Dec 5;16(23):6088-91. doi: 10.1021/ol503170b. Epub 2014 Nov 20. Org Lett. 2014. PMID: 25412436

8

Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.

Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Hewitt WM, et al. Among authors: lokey rs. J Am Chem Soc. 2015 Jan 21;137(2):715-21. doi: 10.1021/ja508766b. Epub 2015 Jan 8. J Am Chem Soc. 2015. PMID: 25517352

9

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.

Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Bockus AT, et al. Among authors: lokey rs. J Med Chem. 2015 Jun 11;58(11):4581-9. doi: 10.1021/acs.jmedchem.5b00128. Epub 2015 May 20. J Med Chem. 2015. PMID: 25950816

10

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides.

Schwochert J, Turner R, Thang M, Berkeley RF, Ponkey AR, Rodriguez KM, Leung SS, Khunte B, Goetz G, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Jacobson MP, Lokey RS. Schwochert J, et al. Among authors: lokey rs. Org Lett. 2015 Jun 19;17(12):2928-31. doi: 10.1021/acs.orglett.5b01162. Epub 2015 Jun 5. Org Lett. 2015. PMID: 26046483

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