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Gene-nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E epsilon4-carrying free-living individuals.
Loktionov A, Scollen S, McKeown N, Bingham SA. Loktionov A, et al. Br J Nutr. 2000 Dec;84(6):885-90. Br J Nutr. 2000. PMID: 11177205
There was a significant correlation between total serum cholesterol and intake of energy derived from total fat (r 0.195; P 0.025) and saturated fat (r 0.174; P 0.046) in the cohort as a whole. ...A significant positive correlation between alcohol consumption …
There was a significant correlation between total serum cholesterol and intake of energy derived from total fat (r 0.195; P 0.025) an …
Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis.
Loktionov A, Watson MA, Stebbings WS, Speakman CT, Bingham SA. Loktionov A, et al. Cancer Lett. 2003 Jan 28;189(2):189-96. doi: 10.1016/s0304-3835(02)00556-6. Cancer Lett. 2003. PMID: 12490312
Plasminogen activator inhibitor-1 (PAI-1) is a factor in urokinase-type plasminogen activator proteolytic system, which is important for tumour invasion and metastasis. ...Nevertheless, within the case group, the 4G/4G genotype was associated with more advanced tumours (Du …
Plasminogen activator inhibitor-1 (PAI-1) is a factor in urokinase-type plasminogen activator proteolytic system, which is important …
Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention.
Loktionov A, Moore W, Spencer SP, Vorster H, Nell T, O'Neill IK, Bingham SA, Cummings JH. Loktionov A, et al. Cancer Detect Prev. 2002;26(1):15-22. doi: 10.1016/s0361-090x(02)00010-7. Cancer Detect Prev. 2002. PMID: 12088198
Black South Africans have a unique incidence pattern of environment-related cancers, but genetic characteristics of this population are mostly unknown. ...The significant differences in N-acetylation genotypes can be among the factors determining a distinctive cance …
Black South Africans have a unique incidence pattern of environment-related cancers, but genetic characteristics of this population a …
Common gene polymorphisms and nutrition: emerging links with pathogenesis of multifactorial chronic diseases (review).
Loktionov A. Loktionov A. J Nutr Biochem. 2003 Aug;14(8):426-51. doi: 10.1016/s0955-2863(03)00032-9. J Nutr Biochem. 2003. PMID: 12948874 Review.
Food intake control may be affected by polymorphisms in the genes encoding taste receptors and a number of peripheral signaling peptides such as insulin, leptin, ghrelin, cholecystokinin, and corresponding receptors. ...CVD-related gene polymorphisms comprising those invol …
Food intake control may be affected by polymorphisms in the genes encoding taste receptors and a number of peripheral signaling pepti …
Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis.
Watson MA, Gay L, Stebbings WS, Speakman CT, Bingham SA, Loktionov A. Watson MA, et al. Clin Sci (Lond). 2003 May;104(5):537-45. doi: 10.1042/CS20020329. Clin Sci (Lond). 2003. PMID: 12529167
Apolipoprotein E ( ApoE ) gene polymorphism is a major factor in lipid metabolism. It has been suggested that this polymorphism can modulate colorectal tumour risk. ...These results suggest that ApoE genotype can influence both CRC risk and prognosis of the existing diseas …
Apolipoprotein E ( ApoE ) gene polymorphism is a major factor in lipid metabolism. It has been suggested that this polymorphism can m …
Common gene polymorphisms, cancer progression and prognosis.
Loktionov A. Loktionov A. Cancer Lett. 2004 May 10;208(1):1-33. doi: 10.1016/j.canlet.2004.02.009. Cancer Lett. 2004. PMID: 15105042 Review.
Therefore the role of normal genetic variation emerges as a major factor determining different aspects of neoplastic growth and eventually outcome of the disease. ...It is evident that large studies based upon combined analysis of groups of genes within relevant regulatory …
Therefore the role of normal genetic variation emerges as a major factor determining different aspects of neoplastic growth and event …
Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular disease risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old women.
Atkinson C, Oosthuizen W, Scollen S, Loktionov A, Day NE, Bingham SA. Atkinson C, et al. J Nutr. 2004 Jul;134(7):1759-64. doi: 10.1093/jn/134.7.1759. J Nutr. 2004. PMID: 15226466 Clinical Trial.
Data suggest that soy protein, a source of isoflavones, may have favorable effects on cardiovascular risk factors. Women (n = 205), ages 49-65 y, were randomized into this double blind, placebo-controlled trial of 43.5 mg red clover-derived isoflavones/d. ...A large …
Data suggest that soy protein, a source of isoflavones, may have favorable effects on cardiovascular risk factors. Women (n = 205), a …
Diet-genotype interactions: an example from tea.
Loktionov A, Bingham SA, Cummings JH. Loktionov A, et al. Br J Nutr. 1997 Dec;78(6):1043-4. Br J Nutr. 1997. PMID: 9497454 No abstract available.
Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot study.
Loktionov A, Bingham SA, Vorster H, Jerling JC, Runswick SA, Cummings JH. Loktionov A, et al. Br J Nutr. 1998 Feb;79(2):133-9. doi: 10.1079/bjn19980024. Br J Nutr. 1998. PMID: 9536857 Clinical Trial.
Tea also caused a significant decrease of PAI-1 activity in the subjects with E2/E3 genotype (mean placebo 7.21 U/ml v. mean tea 5.88 U/ml, P = 0.007). ...The results indicate that tea drinking has a beneficial effect on some cardiovascular disease risk-associated f …
Tea also caused a significant decrease of PAI-1 activity in the subjects with E2/E3 genotype (mean placebo 7.21 U/ml v. mean tea 5.88 …
NQO1 and mEH exon 4 (mEH4) gene polymorphisms, smoking and colorectal cancer risk.
Mitrou P, Watson M, Bingham S, Stebbings WS, Speakman CT, Loktionov A. Mitrou P, et al. IARC Sci Publ. 2002;156:495-7. IARC Sci Publ. 2002. PMID: 12484241 No abstract available.
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