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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Elliott PR, Lomas DA, Carrell RW, Abrahams JP. Elliott PR, et al. Among authors: lomas da. Nat Struct Biol. 1996 Aug;3(8):676-81. doi: 10.1038/nsb0896-676. Nat Struct Biol. 1996. PMID: 8756325
Author Correction: α1-Antitrypsin deficiency.
Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG. Greene CM, et al. Among authors: lomas da. Nat Rev Dis Primers. 2018 Oct 29;4(1):40. doi: 10.1038/s41572-018-0043-2. Nat Rev Dis Primers. 2018. PMID: 30374103
Liver: Taking out the JuNK to treat α1-antitrypsin deficiency.
Rashid ST, Lomas DA. Rashid ST, et al. Among authors: lomas da. Nat Rev Gastroenterol Hepatol. 2017 Apr;14(4):201-202. doi: 10.1038/nrgastro.2017.22. Epub 2017 Mar 8. Nat Rev Gastroenterol Hepatol. 2017. PMID: 28270697 No abstract available.
A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
Ordóñez A, Pérez J, Tan L, Dickens JA, Motamedi-Shad N, Irving JA, Haq I, Ekeowa U, Marciniak SJ, Miranda E, Lomas DA. Ordóñez A, et al. Among authors: lomas da. FASEB J. 2015 Jun;29(6):2667-78. doi: 10.1096/fj.14-267351. Epub 2015 Mar 10. FASEB J. 2015. PMID: 25757566 Free PMC article.
Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.
Laffranchi M, Berardelli R, Ronzoni R, Lomas DA, Fra A. Laffranchi M, et al. Among authors: lomas da. Hum Mol Genet. 2018 May 15;27(10):1785-1793. doi: 10.1093/hmg/ddy090. Hum Mol Genet. 2018. PMID: 29538751
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.
Miranda E, Ferrarotti I, Berardelli R, Laffranchi M, Cerea M, Gangemi F, Haq I, Ottaviani S, Lomas DA, Irving JA, Fra A. Miranda E, et al. Among authors: lomas da. FEBS J. 2017 Jul;284(13):2110-2126. doi: 10.1111/febs.14111. Epub 2017 Jun 8. FEBS J. 2017. PMID: 28504839 Free PMC article.
The molecular and cellular pathology of α₁-antitrypsin deficiency.
Gooptu B, Dickens JA, Lomas DA. Gooptu B, et al. Among authors: lomas da. Trends Mol Med. 2014 Feb;20(2):116-27. doi: 10.1016/j.molmed.2013.10.007. Epub 2013 Dec 25. Trends Mol Med. 2014. PMID: 24374162 Review.
Therapeutic target-site variability in α1-antitrypsin characterized at high resolution.
Patschull AO, Segu L, Nyon MP, Lomas DA, Nobeli I, Barrett TE, Gooptu B. Patschull AO, et al. Among authors: lomas da. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1492-7. doi: 10.1107/S1744309111040267. Epub 2011 Nov 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22139150 Free PMC article.
Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design.
Gooptu B, Miranda E, Nobeli I, Mallya M, Purkiss A, Brown SC, Summers C, Phillips RL, Lomas DA, Barrett TE. Gooptu B, et al. Among authors: lomas da. J Mol Biol. 2009 Apr 10;387(4):857-68. doi: 10.1016/j.jmb.2009.01.069. Epub 2009 Feb 14. J Mol Biol. 2009. PMID: 19232354 Free PMC article.
Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Gooptu B, Lomas DA. Gooptu B, et al. Among authors: lomas da. Annu Rev Biochem. 2009;78:147-76. doi: 10.1146/annurev.biochem.78.082107.133320. Annu Rev Biochem. 2009. PMID: 19245336 Review.
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