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Page 1
Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes.
Peters CH, Abdelsayed M, Ruben PC. Peters CH, et al. Prog Biophys Mol Biol. 2016 Jan;120(1-3):77-88. doi: 10.1016/j.pbiomolbio.2015.12.009. Epub 2015 Dec 20. Prog Biophys Mol Biol. 2016. PMID: 26713557 Review.
Of these genes, 4 alter sodium currents, and the most common known genetic cause remains loss-of-function mutants in the cardiac sodium channel gene SCN5A. Long QT syndrome (LQTs) has a much longer history and is associated with at least 17 genes. ...In this …
Of these genes, 4 alter sodium currents, and the most common known genetic cause remains loss-of-function mutants in the cardiac sodium chan …
Ion channels, long QT syndrome and arrhythmogenesis in ageing.
Jeevaratnam K, Chadda KR, Salvage SC, Valli H, Ahmad S, Grace AA, Huang CL. Jeevaratnam K, et al. Clin Exp Pharmacol Physiol. 2017 Dec;44 Suppl 1(Suppl Suppl 1):38-45. doi: 10.1111/1440-1681.12721. Epub 2017 Sep 20. Clin Exp Pharmacol Physiol. 2017. PMID: 28024120 Free PMC article. Review.
The present review now explores complementary relationships arising from gain-of-function Na(v) 1.5 mutations associated with long QT3 (LQTS3). LQTS3 patients show increased risks of life-threatening ventricular arrhythmias, particularly after 40 years of age, consistent w …
The present review now explores complementary relationships arising from gain-of-function Na(v) 1.5 mutations associated with long QT …
Late sodium current associated cardiac electrophysiological and mechanical dysfunction.
Yu S, Li G, Huang CL, Lei M, Wu L. Yu S, et al. Pflugers Arch. 2018 Mar;470(3):461-469. doi: 10.1007/s00424-017-2079-7. Epub 2017 Nov 10. Pflugers Arch. 2018. PMID: 29127493 Review.
The endogenous I(NaL) is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced I(Na,L) occurs in long QT syndro …
The endogenous I(NaL) is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with …
Cardiac late Na⁺ current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress.
Belardinelli L, Giles WR, Rajamani S, Karagueuzian HS, Shryock JC. Belardinelli L, et al. Heart Rhythm. 2015 Feb;12(2):440-8. doi: 10.1016/j.hrthm.2014.11.009. Epub 2014 Nov 11. Heart Rhythm. 2015. PMID: 25460862 Review.
An increase in I(Na-L) reduces repolarization reserve in atrial and ventricular myocytes and prolongs the action potential duration and the QT interval. An enhanced I(Na-L) is a cause of long QT syndrome 3. ...In this review, we discuss some of …
An increase in I(Na-L) reduces repolarization reserve in atrial and ventricular myocytes and prolongs the action potential duration and the …
Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.
Aromolaran AS, Chahine M, Boutjdir M. Aromolaran AS, et al. Handb Exp Pharmacol. 2018;246:161-184. doi: 10.1007/164_2017_53. Handb Exp Pharmacol. 2018. PMID: 29032483 Review.
Specifically, we discuss: (1) recent literature on the structural, molecular, and functional properties of cardiac Na(v)1.5 channels; (2) how these properties may be altered by phosphorylation in disease states underlain by congenital mutations in Na(v)1.5 channel and/or subunits …
Specifically, we discuss: (1) recent literature on the structural, molecular, and functional properties of cardiac Na(v)1.5 channels; (2) ho …
Protein-protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression.
Shao D, Okuse K, Djamgoz MB. Shao D, et al. Int J Biochem Cell Biol. 2009 Jul;41(7):1471-81. doi: 10.1016/j.biocel.2009.01.016. Epub 2009 Feb 2. Int J Biochem Cell Biol. 2009. PMID: 19401147 Review.
VGSC abnormalities are associated with various diseases including epilepsy, long-QT syndrome 3, Brugada syndrome, sudden infant death syndrome and, more recently, various human cancers. ...
VGSC abnormalities are associated with various diseases including epilepsy, long-QT syndrome 3, Brugada syndr …
Diagnosis and treatment of arrhythmias.
Perry JC, Garson A Jr. Perry JC, et al. Adv Pediatr. 1989;36:177-99. Adv Pediatr. 1989. PMID: 2675568 Review.
There are several important "take home messages" provided here, gleaned from this chapter--the "do nots." Do not (1) use digoxin chronically in overt WPW syndrome, (2) miss the diagnosis of long QT syndrome, (3) diagnose "SVT with aberration"--r …
There are several important "take home messages" provided here, gleaned from this chapter--the "do nots." Do not (1) use digoxin chronically …