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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease.
Arron HE, Marsh BD, Kell DB, Khan MA, Jaeger BR, Pretorius E. Arron HE, et al. Front Immunol. 2024 Jun 3;15:1386607. doi: 10.3389/fimmu.2024.1386607. eCollection 2024. Front Immunol. 2024. PMID: 38887284 Free PMC article. Review.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, debilitating disease characterised by a wide range of symptoms that severely impact all aspects of life. Despite its significant prevalence, ME/CFS remains one of the most …
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, debilitating disease characterised by a wide …
Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID.
Liu Z, Hollmann C, Kalanidhi S, Grothey A, Keating S, Mena-Palomo I, Lamer S, Schlosser A, Kaiping A, Scheller C, Sotzny F, Horn A, Nürnberger C, Cejka V, Afshar B, Bahmer T, Schreiber S, Vehreschild JJ, Miljukov O, Schäfer C, Kretzler L, Keil T, Reese JP, Eichner FA, Schmidbauer L, Heuschmann PU, Störk S, Morbach C, Riemekasten G, Beyersdorf N, Scheibenbogen C, Naviaux RK, Williams M, Ariza ME, Prusty BK. Liu Z, et al. medRxiv [Preprint]. 2023 Jun 29:2023.06.23.23291827. doi: 10.1101/2023.06.23.23291827. medRxiv. 2023. PMID: 37425897 Free PMC article. Preprint.
ME/CFS patients share overlapping symptoms with long COVID patients, an observation which has strengthened the infectious origin hypothesis of ME/CFS. ...Our data show altered active immune complexes, immunoglobulin-mediated mitochondrial …
ME/CFS patients share overlapping symptoms with long COVID patients, an observation which has strengthened the i …
Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses.
Nunes JM, Kell DB, Pretorius E. Nunes JM, et al. Blood Rev. 2023 Jul;60:101075. doi: 10.1016/j.blre.2023.101075. Epub 2023 Mar 20. Blood Rev. 2023. PMID: 36963989 Free PMC article. Review.
Insight from the study of Long COVID/Post Acute Sequelae of COVID-19 (PASC), the post-viral syndrome associated with SARS-CoV-2 infection, might prove to be useful for understanding pathophysiological mechanisms of ME/CFS …
Insight from the study of Long COVID/Post Acute Sequelae of COVID-19 (PASC), the post-viral syn …
Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Syed AM, Karius AK, Ma J, Wang PY, Hwang PM. Syed AM, et al. Physiology (Bethesda). 2025 Jul 1;40(4):0. doi: 10.1152/physiol.00056.2024. Epub 2025 Feb 17. Physiology (Bethesda). 2025. PMID: 39960432 Free PMC article. Review.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms is prolonged fatigue following exertion, a feature also observed in …
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder of unclear etiology …
Oxidative stress is a shared characteristic of ME/CFS and Long COVID.
Shankar V, Wilhelmy J, Curtis EJ, Michael B, Cervantes L, Mallajosyula V, Davis RW, Snyder M, Younis S, Robinson WH, Shankar S, Mischel PS, Bonilla H, Davis MM. Shankar V, et al. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2426564122. doi: 10.1073/pnas.2426564122. Epub 2025 Jul 8. Proc Natl Acad Sci U S A. 2025. PMID: 40627396 Free PMC article.
Over 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition marked by fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). …
Over 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition marked by fatig …
Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies.
Annesley SJ, Missailidis D, Heng B, Josev EK, Armstrong CW. Annesley SJ, et al. Trends Mol Med. 2024 May;30(5):443-458. doi: 10.1016/j.molmed.2024.02.003. Epub 2024 Mar 4. Trends Mol Med. 2024. PMID: 38443223 Free article. Review.
The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed 'long COVID' (LC). Both ME/CFS and LC share many c …
The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 …
Molecular Mechanisms of Neuroinflammation in ME/CFS and Long COVID to Sustain Disease and Promote Relapses.
Tate W, Walker M, Sweetman E, Helliwell A, Peppercorn K, Edgar C, Blair A, Chatterjee A. Tate W, et al. Front Neurol. 2022 May 25;13:877772. doi: 10.3389/fneur.2022.877772. eCollection 2022. Front Neurol. 2022. PMID: 35693009 Free PMC article.
Signaling through recognized pathways from the brain back to body physiology is likely part of the process by which the illness cycle in the peripheral system is sustained and why healing does not occur. By contrast, Long COVID (Post-COVID-19 condition …
Signaling through recognized pathways from the brain back to body physiology is likely part of the process by which the illness cycle in the …
The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.
Kell DB, Pretorius E. Kell DB, et al. Biochem J. 2022 Aug 31;479(16):1653-1708. doi: 10.1042/BCJ20220154. Biochem J. 2022. PMID: 36043493 Free PMC article. Review.
We argue here that I-R injury also underpins elements of the pathology of a variety of chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. ...
We argue here that I-R injury also underpins elements of the pathology of a variety of chronic, inflammatory diseases, including rheu …
Long COVID: lights and shadows on the clinical characterization of this emerging pathology.
Cogliandro V, Bonfanti P. Cogliandro V, et al. New Microbiol. 2024 May;47(1):15-27. New Microbiol. 2024. PMID: 38700879 Free article. Review.
It was estimated that almost 10-20% of these might suffer from Long COVID. It is a multisystemic syndrome, which negatively affects the quality of life with a significant burden of health loss compared to COVID negative individuals. ...This review summ …
It was estimated that almost 10-20% of these might suffer from Long COVID. It is a multisystemic syndrome, which negati …
Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis.
Taylor K, Pearson M, Das S, Sardell J, Chocian K, Gardner S. Taylor K, et al. J Transl Med. 2023 Nov 1;21(1):775. doi: 10.1186/s12967-023-04588-4. J Transl Med. 2023. PMID: 37915075 Free PMC article.
We also identified overlap in the genes associated with Fatigue Dominant long COVID and ME/CFS, including several involved in circadian rhythm regulation and insulin regulation. Overall, 39 SNPs associated in this study with long COVID ca …
We also identified overlap in the genes associated with Fatigue Dominant long COVID and ME/CFS, including severa …
44 results