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Skeletal muscle adaptations and post-exertional malaise in long COVID.
Charlton BT, Goulding RP, Jaspers RT, Appelman B, van Vugt M, Wüst RCI. Charlton BT, et al. Trends Endocrinol Metab. 2025 Jul;36(7):614-622. doi: 10.1016/j.tem.2024.11.008. Epub 2024 Dec 17. Trends Endocrinol Metab. 2025. PMID: 39694730 Free article. Review.
When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise …
When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Sympto …
Muscle abnormalities worsen after post-exertional malaise in long COVID.
Appelman B, Charlton BT, Goulding RP, Kerkhoff TJ, Breedveld EA, Noort W, Offringa C, Bloemers FW, van Weeghel M, Schomakers BV, Coelho P, Posthuma JJ, Aronica E, Joost Wiersinga W, van Vugt M, Wüst RCI. Appelman B, et al. Nat Commun. 2024 Jan 4;15(1):17. doi: 10.1038/s41467-023-44432-3. Nat Commun. 2024. PMID: 38177128 Free PMC article.
With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity …
With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional …
Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.
Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y, Redfield S, Austin JP, Akrami A. Davis HE, et al. EClinicalMedicine. 2021 Aug;38:101019. doi: 10.1016/j.eclinm.2021.101019. Epub 2021 Jul 15. EClinicalMedicine. 2021. PMID: 34308300 Free PMC article.
BACKGROUND: A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. Few systematic studies have investigated this population, particularly in outpatient settings. ...METHODS: We conducted an online survey of p …
BACKGROUND: A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. F …
Long COVID in pediatrics-epidemiology, diagnosis, and management.
Toepfner N, Brinkmann F, Augustin S, Stojanov S, Behrends U. Toepfner N, et al. Eur J Pediatr. 2024 Apr;183(4):1543-1553. doi: 10.1007/s00431-023-05360-y. Epub 2024 Jan 27. Eur J Pediatr. 2024. PMID: 38279014 Free PMC article. Review.
This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID-19 condition (PCC) in children and adolescents. ...Current health care structures have to be adapted, and research was extended to me …
This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID- …
Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-exertional Malaise: A Best Practice Proposal.
Gloeckl R, Zwick RH, Fürlinger U, Schneeberger T, Leitl D, Jarosch I, Behrends U, Scheibenbogen C, Koczulla AR. Gloeckl R, et al. Sports Med Open. 2024 Apr 24;10(1):47. doi: 10.1186/s40798-024-00695-8. Sports Med Open. 2024. PMID: 38658496 Free PMC article.
People with long COVID may suffer from a wide range of ongoing symptoms including fatigue, exertional dyspnea, reduced exercise performance, and others. ...However, clinical experience has shown that the presence of post-exertional malaise …
People with long COVID may suffer from a wide range of ongoing symptoms including fatigue, exertional dyspnea, reduced …
ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature.
Komaroff AL, Lipkin WI. Komaroff AL, et al. Front Med (Lausanne). 2023 Jun 2;10:1187163. doi: 10.3389/fmed.2023.1187163. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37342500 Free PMC article. Review.
Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other …
Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive prob …
Distinguishing features of long COVID identified through immune profiling.
Klein J, Wood J, Jaycox JR, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott IM, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng TJ, Xu L, Geraghty AC, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick JD, Kaminski N, Omer SB, Krumholz HM, Guan L, Dela Cruz CS, van Dijk D, Ring AM, Putrino D, Iwasaki A. Klein J, et al. Nature. 2023 Nov;623(7985):139-148. doi: 10.1038/s41586-023-06651-y. Epub 2023 Sep 25. Nature. 2023. PMID: 37748514 Free PMC article.
Post-acute infection syndromes may develop after acute viral disease(1). Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome known as long COVID. Individuals with long COVID freq …
Post-acute infection syndromes may develop after acute viral disease(1). Infection with SARS-CoV-2 can result in the developme …
ME/CFS and Post-Exertional Malaise among Patients with Long COVID.
Jason LA, Dorri JA. Jason LA, et al. Neurol Int. 2022 Dec 20;15(1):1-11. doi: 10.3390/neurolint15010001. Neurol Int. 2022. PMID: 36648965 Free PMC article.
This study sought to ascertain the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among a sample of 465 patients with Long COVID. The participants completed three questionnaires: (1) a new questionnaire measuring both the frequency …
This study sought to ascertain the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among a sample of 465 pa …
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence.
Scheibenbogen C, Wirth KJ. Scheibenbogen C, et al. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13669. doi: 10.1002/jcsm.13669. J Cachexia Sarcopenia Muscle. 2025. PMID: 39727052 Free PMC article. Review.
We try to explain which risk factors and mechanisms are responsible for a subgroup of patients with post COVID syndrome (PCS) to develop ME/CFS (PC-ME/CFS). RESULTS: Mitochondrial dysfunction is a long-held assumption to explain cardinal symptoms of ME …
We try to explain which risk factors and mechanisms are responsible for a subgroup of patients with post COVID syndrome …
Post-exertional malaise in Long COVID: subjective reporting versus objective assessment.
Stussman B, Camarillo N, McCrossin G, Stockman M, Norato G, Vetter CS, Ferrufino A, Adedamola A, Grayson N, Nath A, Chan L, Walitt B, Chin LMK. Stussman B, et al. Front Neurol. 2025 Apr 23;16:1534352. doi: 10.3389/fneur.2025.1534352. eCollection 2025. Front Neurol. 2025. PMID: 40337174 Free PMC article.
BACKGROUND: Post-exertional malaise (PEM) is a central feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and has emerged as a prominent feature of Long COVID. ...When present, PEM descriptions during QI were less seve …
BACKGROUND: Post-exertional malaise (PEM) is a central feature of myalgic encephalomyelitis/chronic fatigue syndrome …
188 results