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Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.
Zhou A, Hyppönen E. Zhou A, et al. Am J Clin Nutr. 2019 Mar 1;109(3):509-516. doi: 10.1093/ajcn/nqy297. Am J Clin Nutr. 2019. PMID: 30838377
However, increased risk of myocardial infarction and hypertension has been suggested for individuals who carry a functional variant at cytochrome P450 1A2 (CYP1A2), which makes them less effective at metabolizing caffeine. OBJECTIVES: The aim of this study was to ex …
However, increased risk of myocardial infarction and hypertension has been suggested for individuals who carry a functional variant at cytoc …
Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.
Zhou A, Taylor AE, Karhunen V, Zhan Y, Rovio SP, Lahti J, Sjögren P, Byberg L, Lyall DM, Auvinen J, Lehtimäki T, Kähönen M, Hutri-Kähönen N, Perälä MM, Michaëlsson K, Mahajan A, Lind L, Power C, Eriksson JG, Raitakari OT, Hägg S, Pedersen NL, Veijola J, Järvelin MR, Munafò MR, Ingelsson E, Llewellyn DJ, Hyppönen E. Zhou A, et al. Sci Rep. 2018 May 14;8(1):7526. doi: 10.1038/s41598-018-25919-2. Sci Rep. 2018. PMID: 29760501 Free PMC article.
Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. ...Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effe
Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and advers
Metabolomic Signatures of Long-term Coffee Consumption and Risk of Type 2 Diabetes in Women.
Hang D, Zeleznik OA, He X, Guasch-Ferre M, Jiang X, Li J, Liang L, Eliassen AH, Clish CB, Chan AT, Hu Z, Shen H, Wilson KM, Mucci LA, Sun Q, Hu FB, Willett WC, Giovannucci EL, Song M. Hang D, et al. Diabetes Care. 2020 Oct;43(10):2588-2596. doi: 10.2337/dc20-0800. Epub 2020 Aug 11. Diabetes Care. 2020. PMID: 32788283
These associations were generally consistent for caffeinated and decaffeinated coffee, except for caffeine and its metabolites that were only associated with caffeinated coffee intake. ...Similar improvement was observed in the validation set. C …
These associations were generally consistent for caffeinated and decaffeinated coffee, except for caffeine and its meta …
Tea, coffee, caffeine intake and the risk of cardio-metabolic outcomes: findings from a population with low coffee and high tea consumption.
Gaeini Z, Bahadoran Z, Mirmiran P, Azizi F. Gaeini Z, et al. Nutr Metab (Lond). 2019 May 3;16:28. doi: 10.1186/s12986-019-0355-6. eCollection 2019. Nutr Metab (Lond). 2019. PMID: 31073321 Free PMC article.
BACKGROUND: This study aimed to assess the potential effects of long-term intake of caffeine and habitual consumption of coffee and tea on the occurrence of cardio-renal events among an Iranian population with low coffee and high tea c
BACKGROUND: This study aimed to assess the potential effects of long-term intake of caffeine and habitual consumptio
Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease.
Carman AJ, Dacks PA, Lane RF, Shineman DW, Fillit HM. Carman AJ, et al. J Nutr Health Aging. 2014 Apr;18(4):383-92. doi: 10.1007/s12603-014-0021-7. J Nutr Health Aging. 2014. PMID: 24676319 Review.
While coffee and caffeine are known to enhance short-term memory and cognition, some limited research also suggests that long-term use may protect against cognitive decline or dementia. ...To our knowledge, no evidence has been gathered from ran …
While coffee and caffeine are known to enhance short-term memory and cognition, some limited research also suggests tha …
[Side effects of caffeine].
Dworzański W, Opielak G, Burdan F. Dworzański W, et al. Pol Merkur Lekarski. 2009 Nov;27(161):357-61. Pol Merkur Lekarski. 2009. PMID: 19999796 Polish.
However, the long-term consumption reduces the incidence of the type 2 diabetes mellitus. ...The final manifestation of side reactions is dependent on the genotype, especially polymorphisms of genes associated with caffeine metabolism, i.e., cyt …
However, the long-term consumption reduces the incidence of the type 2 diabetes mellitus. ...The final manifestation of …
Caffeine, adenosine receptors, and synaptic plasticity.
Costenla AR, Cunha RA, de Mendonça A. Costenla AR, et al. J Alzheimers Dis. 2010;20 Suppl 1:S25-34. doi: 10.3233/JAD-2010-091384. J Alzheimers Dis. 2010. PMID: 20182030 Review.
Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micr …
Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations o …
Embryonic caffeine exposure acts via A1 adenosine receptors to alter adult cardiac function and DNA methylation in mice.
Buscariollo DL, Fang X, Greenwood V, Xue H, Rivkees SA, Wendler CC. Buscariollo DL, et al. PLoS One. 2014 Jan 27;9(1):e87547. doi: 10.1371/journal.pone.0087547. eCollection 2014. PLoS One. 2014. PMID: 24475304 Free PMC article.
Our aim was to determine whether adenosine A1 receptors (A1ARs) mediate the long-term effects of in utero caffeine exposure on cardiac function and whether these long-term effects are the result of changes in DNA methylation patterns in adult he …
Our aim was to determine whether adenosine A1 receptors (A1ARs) mediate the long-term effects of in utero caffeine expo …
Differences in the effect of chronic and acute caffeine on self-administration of cocaine in mice.
Kuzmin A, Johansson B, Semenova S, Fredholm BB. Kuzmin A, et al. Eur J Neurosci. 2000 Aug;12(8):3026-32. doi: 10.1046/j.1460-9568.2000.00179.x. Eur J Neurosci. 2000. PMID: 10971643
We have compared the ability of an acute injection of caffeine (3 mg/kg, i.p.) and long-term peroral caffeine consumption for 10 days ( approximately 150 mg/kg/day in tap water) to affect cocaine self-administration in mice. ...However, caffe
We have compared the ability of an acute injection of caffeine (3 mg/kg, i.p.) and long-term peroral caffeine
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