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Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders.
Chan SS, Longley MJ, Copeland WC. Chan SS, et al. Among authors: longley mj. Hum Mol Genet. 2006 Dec 1;15(23):3473-83. doi: 10.1093/hmg/ddl424. Epub 2006 Nov 6. Hum Mol Genet. 2006. PMID: 17088268 Free PMC article.
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity.
Longley MJ, Ropp PA, Lim SE, Copeland WC. Longley MJ, et al. Biochemistry. 1998 Jul 21;37(29):10529-39. doi: 10.1021/bi980772w. Biochemistry. 1998. PMID: 9671525
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro.
Longley MJ, Prasad R, Srivastava DK, Wilson SH, Copeland WC. Longley MJ, et al. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12244-8. doi: 10.1073/pnas.95.21.12244. Proc Natl Acad Sci U S A. 1998. PMID: 9770471 Free PMC article.
The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance.
Lim SE, Longley MJ, Copeland WC. Lim SE, et al. Among authors: longley mj. J Biol Chem. 1999 Dec 31;274(53):38197-203. doi: 10.1074/jbc.274.53.38197. J Biol Chem. 1999. PMID: 10608893
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit.
Longley MJ, Nguyen D, Kunkel TA, Copeland WC. Longley MJ, et al. J Biol Chem. 2001 Oct 19;276(42):38555-62. doi: 10.1074/jbc.M105230200. Epub 2001 Aug 14. J Biol Chem. 2001. PMID: 11504725
Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis.
Ponamarev MV, Longley MJ, Nguyen D, Kunkel TA, Copeland WC. Ponamarev MV, et al. Among authors: longley mj. J Biol Chem. 2002 May 3;277(18):15225-8. doi: 10.1074/jbc.C200100200. Epub 2002 Mar 15. J Biol Chem. 2002. PMID: 11897778
Purification, separation, and identification of the human mtDNA polymerase with and without its accessory subunit.
Longley MJ, Copeland WC. Longley MJ, et al. Methods Mol Biol. 2002;197:245-57. doi: 10.1385/1-59259-284-8:245. Methods Mol Biol. 2002. PMID: 12013800 No abstract available.
Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders.
Copeland WC, Ponamarev MV, Nguyen D, Kunkel TA, Longley MJ. Copeland WC, et al. Among authors: longley mj. Acta Biochim Pol. 2003;50(1):155-67. Acta Biochim Pol. 2003. PMID: 12673356 Review.
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
Lim SE, Ponamarev MV, Longley MJ, Copeland WC. Lim SE, et al. Among authors: longley mj. J Mol Biol. 2003 May 23;329(1):45-57. doi: 10.1016/s0022-2836(03)00405-4. J Mol Biol. 2003. PMID: 12742017
DNA polymerase gamma in mitochondrial DNA replication and repair.
Copeland WC, Longley MJ. Copeland WC, et al. Among authors: longley mj. ScientificWorldJournal. 2003 Mar 17;3:34-44. doi: 10.1100/tsw.2003.09. ScientificWorldJournal. 2003. PMID: 12806118 Free PMC article. Review.
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