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Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.
Aitken JF, Loomes KM, Konarkowska B, Cooper GJ. Aitken JF, et al. Among authors: loomes km. Biochem J. 2003 Sep 15;374(Pt 3):779-84. doi: 10.1042/BJ20030422. Biochem J. 2003. PMID: 12812521 Free PMC article.
Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes.
Bailey RJ, Walker CS, Ferner AH, Loomes KM, Prijic G, Halim A, Whiting L, Phillips AR, Hay DL. Bailey RJ, et al. Among authors: loomes km. Br J Pharmacol. 2012 May;166(1):151-67. doi: 10.1111/j.1476-5381.2011.01717.x. Br J Pharmacol. 2012. PMID: 22014233 Free PMC article.
Survival of an islet β-cell in type-2 diabetes: curbing the effects of amyloid cytotoxicity.
Loomes KM. Loomes KM. Islets. 2011 Jan-Feb;3(1):38-9. doi: 10.4161/isl.3.1.14258. Epub 2011 Jan 1. Islets. 2011. PMID: 21266844 Review.
Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.
Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips AR, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJ. Aitken JF, et al. Among authors: loomes km. Data Brief. 2016 Nov 29;10:298-303. doi: 10.1016/j.dib.2016.11.077. eCollection 2017 Feb. Data Brief. 2016. PMID: 27995166 Free PMC article.
Loomes, I. Riba-Garcia, R.D. Unwin, G. Prijic, A.S. Phillips, A.R.J. Phillips, D. Wu, S.D. Poppitt, K. Ding, P.E. Barran, A.W. ...
Loomes, I. Riba-Garcia, R.D. Unwin, G. Prijic, A.S. Phillips, A.R.J. Phillips, D. Wu, S.D. Poppitt, K. Ding, P.E. Barran, A.W. ...
Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.
Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Aitken JF, et al. Among authors: loomes km. Biochem Biophys Res Commun. 2017 Jan 22;482(4):625-631. doi: 10.1016/j.bbrc.2016.11.083. Epub 2016 Nov 16. Biochem Biophys Res Commun. 2017. PMID: 27865831
The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes.
Chien V, Aitken JF, Zhang S, Buchanan CM, Hickey A, Brittain T, Cooper GJ, Loomes KM. Chien V, et al. Among authors: loomes km. Biochem J. 2010 Nov 15;432(1):113-21. doi: 10.1042/BJ20100434. Biochem J. 2010. PMID: 20735358
Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice.
Aitken JF, Loomes KM, Scott DW, Reddy S, Phillips AR, Prijic G, Fernando C, Zhang S, Broadhurst R, L'Huillier P, Cooper GJ. Aitken JF, et al. Among authors: loomes km. Diabetes. 2010 Jan;59(1):161-71. doi: 10.2337/db09-0548. Epub 2009 Sep 30. Diabetes. 2010. PMID: 19794060 Free PMC article.
Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine.
Payne LS, Brown PM, Middleditch M, Baker E, Cooper GJ, Loomes KM. Payne LS, et al. Among authors: loomes km. Biochem J. 2008 Dec 1;416(2):281-8. doi: 10.1042/BJ20080389. Biochem J. 2008. PMID: 18637789
Synthesis of biologically active tritiated amylin and salmon calcitonin analogues.
Heller M, Loomes KM, Cooper GJ. Heller M, et al. Among authors: loomes km. Anal Biochem. 2000 Oct 1;285(1):100-4. doi: 10.1006/abio.2000.4716. Anal Biochem. 2000. PMID: 10998268
Reaction between sheep liver mitochondrial aldehyde dehydrogenase and various thiol-modifying reagents.
Loomes KM, Kitson TM. Loomes KM, et al. Biochem J. 1989 Jul 1;261(1):281-4. doi: 10.1042/bj2610281. Biochem J. 1989. PMID: 2775216 Free PMC article.
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