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Functional impact bias reveals cancer drivers.
Gonzalez-Perez A, Lopez-Bigas N. Gonzalez-Perez A, et al. Nucleic Acids Res. 2012 Nov;40(21):e169. doi: 10.1093/nar/gks743. Epub 2012 Aug 16. Nucleic Acids Res. 2012. PMID: 22904074 Free PMC article.
Genome-wide identification of genes likely to be involved in human genetic disease.
López-Bigas N, Ouzounis CA. López-Bigas N, et al. Nucleic Acids Res. 2004 Jun 4;32(10):3108-14. doi: 10.1093/nar/gkh605. Print 2004. Nucleic Acids Res. 2004. PMID: 15181176 Free PMC article.
Expansion of the BioCyc collection of pathway/genome databases to 160 genomes.
Karp PD, Ouzounis CA, Moore-Kochlacs C, Goldovsky L, Kaipa P, Ahrén D, Tsoka S, Darzentas N, Kunin V, López-Bigas N. Karp PD, et al. Nucleic Acids Res. 2005 Oct 24;33(19):6083-9. doi: 10.1093/nar/gki892. Print 2005. Nucleic Acids Res. 2005. PMID: 16246909 Free PMC article.
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.
Tiffin N, Adie E, Turner F, Brunner HG, van Driel MA, Oti M, Lopez-Bigas N, Ouzounis C, Perez-Iratxeta C, Andrade-Navarro MA, Adeyemo A, Patti ME, Semple CA, Hide W. Tiffin N, et al. Nucleic Acids Res. 2006 Jun 6;34(10):3067-81. doi: 10.1093/nar/gkl381. Print 2006. Nucleic Acids Res. 2006. PMID: 16757574 Free PMC article.
Differences in the evolutionary history of disease genes affected by dominant or recessive mutations.
Furney SJ, Albà MM, López-Bigas N. Furney SJ, et al. BMC Genomics. 2006 Jul 3;7:165. doi: 10.1186/1471-2164-7-165. BMC Genomics. 2006. PMID: 16817963 Free PMC article.
On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees.
Marques-Bonet T, Sànchez-Ruiz J, Armengol L, Khaja R, Bertranpetit J, Lopez-Bigas N, Rocchi M, Gazave E, Navarro A. Marques-Bonet T, et al. Genome Biol. 2007;8(10):R230. doi: 10.1186/gb-2007-8-10-r230. Genome Biol. 2007. PMID: 17971225 Free PMC article.
Distinct patterns in the regulation and evolution of human cancer genes.
Furney SJ, Madden SF, Kisiel TA, Higgins DG, Lopez-Bigas N. Furney SJ, et al. In Silico Biol. 2008;8(1):33-46. In Silico Biol. 2008. PMID: 18430988
Prioritization of candidate cancer genes--an aid to oncogenomic studies.
Furney SJ, Calvo B, Larrañaga P, Lozano JA, Lopez-Bigas N. Furney SJ, et al. Nucleic Acids Res. 2008 Oct;36(18):e115. doi: 10.1093/nar/gkn482. Epub 2008 Aug 18. Nucleic Acids Res. 2008. PMID: 18710882 Free PMC article.
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation.
Lopez-Bigas N, Kisiel TA, Dewaal DC, Holmes KB, Volkert TL, Gupta S, Love J, Murray HL, Young RA, Benevolenskaya EV. Lopez-Bigas N, et al. Mol Cell. 2008 Aug 22;31(4):520-30. doi: 10.1016/j.molcel.2008.08.004. Mol Cell. 2008. PMID: 18722178 Free PMC article.
Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel.
González-Pérez A, López-Bigas N. González-Pérez A, et al. Am J Hum Genet. 2011 Apr 8;88(4):440-9. doi: 10.1016/j.ajhg.2011.03.004. Epub 2011 Mar 31. Am J Hum Genet. 2011. PMID: 21457909 Free PMC article.
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