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Caspase-1: is IL-1 just the tip of the ICEberg?
Denes A, Lopez-Castejon G, Brough D. Denes A, et al. Cell Death Dis. 2012 Jul 5;3(7):e338. doi: 10.1038/cddis.2012.86. Cell Death Dis. 2012. PMID: 22764097 Free PMC article. Review.
Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta.
López-Castejón G, Young MT, Meseguer J, Surprenant A, Mulero V. López-Castejón G, et al. Mol Immunol. 2007 Feb;44(6):1286-99. doi: 10.1016/j.molimm.2006.05.015. Epub 2006 Jul 11. Mol Immunol. 2007. PMID: 16837047
The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels.
López-Castejón G, Sepulcre MP, Roca FJ, Castellana B, Planas JV, Meseguer J, Mulero V. López-Castejón G, et al. Mol Immunol. 2007 Apr;44(10):2772-80. doi: 10.1016/j.molimm.2006.10.027. Epub 2007 Jan 17. Mol Immunol. 2007. PMID: 17234266
Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish.
López-Castejón G, Sepulcre MP, Mulero I, Pelegrín P, Meseguer J, Mulero V. López-Castejón G, et al. Mol Immunol. 2008 Jan;45(1):49-57. doi: 10.1016/j.molimm.2007.05.015. Epub 2007 Jul 3. Mol Immunol. 2008. PMID: 17610954
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
Lopez-Castejon G, Theaker J, Pelegrin P, Clifton AD, Braddock M, Surprenant A. Lopez-Castejon G, et al. J Immunol. 2010 Aug 15;185(4):2611-9. doi: 10.4049/jimmunol.1000436. Epub 2010 Jul 16. J Immunol. 2010. PMID: 20639492
Understanding the mechanism of IL-1β secretion.
Lopez-Castejon G, Brough D. Lopez-Castejon G, et al. Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95. doi: 10.1016/j.cytogfr.2011.10.001. Epub 2011 Oct 22. Cytokine Growth Factor Rev. 2011. PMID: 22019906 Free PMC article. Review.
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
Small BG, McColl BW, Allmendinger R, Pahle J, López-Castejón G, Rothwell NJ, Knowles J, Mendes P, Brough D, Kell DB. Small BG, et al. Nat Chem Biol. 2011 Oct 23;7(12):902-8. doi: 10.1038/nchembio.689. Nat Chem Biol. 2011. PMID: 22020553 Free PMC article.
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Luheshi NM, Giles JA, Lopez-Castejon G, Brough D. Luheshi NM, et al. Eur J Immunol. 2012 Mar;42(3):716-25. doi: 10.1002/eji.201142079. Epub 2011 Dec 27. Eur J Immunol. 2012. PMID: 22105559 Free PMC article.
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues.
Luheshi NM, Kovács KJ, Lopez-Castejon G, Brough D, Denes A. Luheshi NM, et al. J Neuroinflammation. 2011 Dec 29;8:186. doi: 10.1186/1742-2094-8-186. J Neuroinflammation. 2011. PMID: 22206506 Free PMC article.
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