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Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation.
Nelson BH, Lord JD, Greenberg PD. Nelson BH, et al. Among authors: lord jd. Nature. 1994 May 26;369(6478):333-6. doi: 10.1038/369333a0. Nature. 1994. PMID: 7514277
A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.
Nelson BH, Lord JD, Greenberg PD. Nelson BH, et al. Among authors: lord jd. Mol Cell Biol. 1996 Jan;16(1):309-17. doi: 10.1128/mcb.16.1.309. Mol Cell Biol. 1996. PMID: 8524310 Free PMC article.
Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.
Martino A, Holmes JH 4th, Lord JD, Moon JJ, Nelson BH. Martino A, et al. Among authors: lord jd. J Immunol. 2001 Feb 1;166(3):1723-9. doi: 10.4049/jimmunol.166.3.1723. J Immunol. 2001. PMID: 11160217
The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc.
Lord JD, McIntosh BC, Greenberg PD, Nelson BH. Lord JD, et al. J Immunol. 1998 Nov 1;161(9):4627-33. J Immunol. 1998. PMID: 9794391
The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5.
Lord JD, McIntosh BC, Greenberg PD, Nelson BH. Lord JD, et al. J Immunol. 2000 Mar 1;164(5):2533-41. doi: 10.4049/jimmunol.164.5.2533. J Immunol. 2000. PMID: 10679091
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.
Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH, Neel BG. Gu H, et al. Among authors: lord jd. Mol Cell Biol. 2000 Oct;20(19):7109-20. doi: 10.1128/mcb.20.19.7109-7120.2000. Mol Cell Biol. 2000. PMID: 10982827 Free PMC article.
Role of interleukin (IL)-2 receptor beta-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein Kinase/c-Jun N-terminal kinase) activation. IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation.
Hunt AE, Lali FV, Lord JD, Nelson BH, Miyazaki T, Tracey KJ, Foxwell BM. Hunt AE, et al. Among authors: lord jd. J Biol Chem. 1999 Mar 12;274(11):7591-7. doi: 10.1074/jbc.274.11.7591. J Biol Chem. 1999. PMID: 10066828
Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Van Parijs L, et al. Among authors: lord jd. Immunity. 1999 Sep;11(3):281-8. doi: 10.1016/s1074-7613(00)80103-x. Immunity. 1999. PMID: 10514006 Retracted.
Genetic modification of T-cell clones for therapy of human viral and malignant diseases.
Greenberg PD, Finch RJ, Gavin MA, Kalos M, Lewinsohn DA, Lonergan M, Lord JD, Nelson BH, Ohlén C, Sing AP, Warren EH, Yee C, Riddell SR. Greenberg PD, et al. Among authors: lord jd. Cancer J Sci Am. 1998 May;4 Suppl 1:S100-5. Cancer J Sci Am. 1998. PMID: 9619278 No abstract available.
Escherichiacoli-Specific CD4+ T Cells Have Public T-Cell Receptors and Low Interleukin 10 Production in Crohn's Disease.
Uchida AM, Boden EK, James EA, Shows DM, Konecny AJ, Lord JD. Uchida AM, et al. Among authors: lord jd. Cell Mol Gastroenterol Hepatol. 2020;10(3):507-526. doi: 10.1016/j.jcmgh.2020.04.013. Epub 2020 May 1. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32361018 Free PMC article.
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