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Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression.
Fernández-Veledo S, Nieto-Vazquez I, Rondinone CM, Lorenzo M. Fernández-Veledo S, et al. Diabetologia. 2006 Dec;49(12):3038-48. doi: 10.1007/s00125-006-0472-4. Epub 2006 Oct 27. Diabetologia. 2006. PMID: 17072583
Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats.
Teruel T, Hernandez R, Rial E, Martin-Hidalgo A, Lorenzo M. Teruel T, et al. Diabetologia. 2005 Jun;48(6):1180-8. doi: 10.1007/s00125-005-1744-0. Epub 2005 May 11. Diabetologia. 2005. PMID: 15887043
Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner.
Valverde AM, Navarro P, Teruel T, Conejo R, Benito M, Lorenzo M. Valverde AM, et al. Biochem J. 1999 Feb 1;337 ( Pt 3)(Pt 3):397-405. Biochem J. 1999. PMID: 9895282 Free PMC article.
Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes.
Teruel T, Valverde AM, Navarro P, Benito M, Lorenzo M. Teruel T, et al. J Cell Physiol. 1998 Jul;176(1):99-109. doi: 10.1002/(SICI)1097-4652(199807)176:1<99::AID-JCP12>3.0.CO;2-J. J Cell Physiol. 1998. PMID: 9618150
Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes.
Valverde AM, Lorenzo M, Navarro P, Benito M. Valverde AM, et al. Mol Endocrinol. 1997 May;11(5):595-607. doi: 10.1210/mend.11.5.9924. Mol Endocrinol. 1997. PMID: 9139803
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