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Cohesin in cancer: chromosome segregation and beyond.
Losada A. Losada A. Nat Rev Cancer. 2014 Jun;14(6):389-93. doi: 10.1038/nrc3743. Nat Rev Cancer. 2014. PMID: 24854081 Review.
Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes.
Losada A, Yokochi T, Kobayashi R, Hirano T. Losada A, et al. J Cell Biol. 2000 Aug 7;150(3):405-16. doi: 10.1083/jcb.150.3.405. J Cell Biol. 2000. PMID: 10931856 Free PMC article.
A 14S complex (x-cohesin(SA1)) contains XSMC1, XSMC3, XRAD21, and a newly identified subunit, XSA1. In a second 12.5S complex (x-cohesin(SA2)), XSMC1, XSMC3, and XRAD21 associate with a different subunit, XSA2. ...In Xenopus egg extracts, x-cohesin(SA1
A 14S complex (x-cohesin(SA1)) contains XSMC1, XSMC3, XRAD21, and a newly identified subunit, XSA1. In a second 12.5S c
Intermolecular DNA interactions stimulated by the cohesin complex in vitro: implications for sister chromatid cohesion.
Losada A, Hirano T. Losada A, et al. Curr Biol. 2001 Feb 20;11(4):268-72. doi: 10.1016/s0960-9822(01)00066-5. Curr Biol. 2001. PMID: 11250156
Recent studies in yeast genetics and Xenopus biochemistry have identified a large protein complex, cohesin, that plays a key role in sister chromatid cohesion [5-10]. The cohesin complex consists of a heterodimeric pair of SMC (structural maintenance of chrom …
Recent studies in yeast genetics and Xenopus biochemistry have identified a large protein complex, cohesin, that plays a key r …
Shaping the metaphase chromosome: coordination of cohesion and condensation.
Losada A, Hirano T. Losada A, et al. Bioessays. 2001 Oct;23(10):924-35. doi: 10.1002/bies.1133. Bioessays. 2001. PMID: 11598959 Review.
Condensin is a central player in chromosome condensation, a process that initiates at the onset of mitosis. The main focus of this review is to discuss how the mitotic metaphase chromosome is assembled and shaped by a precise balance between the cohesion and …
Condensin is a central player in chromosome condensation, a process that initiates at the onset of mitosis. The main focus of …
Condensin and cohesin display different arm conformations with characteristic hinge angles.
Anderson DE, Losada A, Erickson HP, Hirano T. Anderson DE, et al. Among authors: losada a. J Cell Biol. 2002 Feb 4;156(3):419-24. doi: 10.1083/jcb.200111002. Epub 2002 Jan 28. J Cell Biol. 2002. PMID: 11815634 Free PMC article.
Each of the complexes consists of a heterodimeric pair of SMC subunits and two or three non-SMC subunits. Previous studies have shown that a bacterial SMC homodimer has a symmetrical structure in which two long coiled-coil arms are connected by a flexi …
Each of the complexes consists of a heterodimeric pair of SMC subunits and two or three non-SMC subunits. Previous studies have shown …
Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis.
Losada A, Hirano M, Hirano T. Losada A, et al. Genes Dev. 2002 Dec 1;16(23):3004-16. doi: 10.1101/gad.249202. Genes Dev. 2002. PMID: 12464631 Free PMC article.
Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.
Losada A, Yokochi T, Hirano T. Losada A, et al. J Cell Sci. 2005 May 15;118(Pt 10):2133-41. doi: 10.1242/jcs.02355. Epub 2005 Apr 26. J Cell Sci. 2005. PMID: 15855230
Central to this process is cohesin, a multi-protein complex conserved from yeast to human. Previous genetic studies in fungi have identified Pds5/BimD/Spo76 as an additional factor implicated in cohesion. ...In HeLa cells, Pds5 proteins physically interact with cohesin and …
Central to this process is cohesin, a multi-protein complex conserved from yeast to human. Previous genetic studies in fungi have ide …
Dynamic molecular linkers of the genome: the first decade of SMC proteins.
Losada A, Hirano T. Losada A, et al. Genes Dev. 2005 Jun 1;19(11):1269-87. doi: 10.1101/gad.1320505. Genes Dev. 2005. PMID: 15937217 Review.
Shugoshin and PP2A, shared duties at the centromere.
Rivera T, Losada A. Rivera T, et al. Among authors: losada a. Bioessays. 2006 Aug;28(8):775-9. doi: 10.1002/bies.20448. Bioessays. 2006. PMID: 16927389 Review.
A tight spatial and temporal control of cohesin release is observed in mitosis and meiosis, and a family of proteins known as shugoshins play a major role in this process. ...Additional evidence, however, suggests that this is only part of the story, and that
A tight spatial and temporal control of cohesin release is observed in mitosis and meiosis, and a family of proteins known as
Cohesin regulation: fashionable ways to wear a ring.
Losada A. Losada A. Chromosoma. 2007 Aug;116(4):321-9. doi: 10.1007/s00412-007-0104-x. Epub 2007 Mar 1. Chromosoma. 2007. PMID: 17333234 Review.
Cohesin is a multiprotein complex, conserved from yeast to humans, that mediates sister chromatid cohesion. Its ring-shaped structure first suggested that it may perform its task by embracing the sister chromatids. ...
Cohesin is a multiprotein complex, conserved from yeast to humans, that mediates sister chromatid cohesion. Its ring-shaped structure …
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