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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
Losiewicz MD, Carlson BA, Kaur G, Sausville EA, Worland PJ. Losiewicz MD, et al. Biochem Biophys Res Commun. 1994 Jun 15;201(2):589-95. doi: 10.1006/bbrc.1994.1742. Biochem Biophys Res Commun. 1994. PMID: 8002990
Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy.
Sedlacek H, Czech J, Naik R, Kaur G, Worland P, Losiewicz M, Parker B, Carlson B, Smith A, Senderowicz A, Sausville E. Sedlacek H, et al. Int J Oncol. 1996 Dec;9(6):1143-68. doi: 10.3892/ijo.9.6.1143. Int J Oncol. 1996. PMID: 21541623
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol.
Parker BW, Kaur G, Nieves-Neira W, Taimi M, Kohlhagen G, Shimizu T, Losiewicz MD, Pommier Y, Sausville EA, Senderowicz AM. Parker BW, et al. Among authors: losiewicz md. Blood. 1998 Jan 15;91(2):458-65. Blood. 1998. PMID: 9427698
Different early effets of tyrphostin AG957 and geldanamycins on mitogen-activated protein kinase and p120cbl phosphorylation in anti CD-3-stimulated T-lymphoblasts.
Losiewicz MD, Kaur G, Sausville EA. Losiewicz MD, et al. Biochem Pharmacol. 1999 Feb 1;57(3):281-9. doi: 10.1016/s0006-2952(98)00293-7. Biochem Pharmacol. 1999. PMID: 9890555
Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice.
Wang R, Liu X, Wu J, Liu H, Wang W, Chen X, Yuan L, Wang Y, Du X, Ma Y, Losiewicz MD, Zhang X, Zhang H. Wang R, et al. Among authors: losiewicz md. Environ Toxicol. 2020 Aug;35(8):822-830. doi: 10.1002/tox.22918. Epub 2020 Mar 14. Environ Toxicol. 2020. PMID: 32170997
The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review.
Du X, Liu H, Yuan L, Wang Y, Ma Y, Wang R, Chen X, Losiewicz MD, Guo H, Zhang H. Du X, et al. Among authors: losiewicz md. Toxins (Basel). 2019 Sep 12;11(9):530. doi: 10.3390/toxins11090530. Toxins (Basel). 2019. PMID: 31547379 Free PMC article.
p53-Dependent pathway and the opening of mPTP mediate the apoptosis of co-cultured Sertoli-germ cells induced by microcystin-LR.
Wu J, Liu H, Huang H, Yuan L, Liu C, Wang Y, Cheng X, Zhuang D, Xu M, Chen X, Losiewicz MD, Zhang H. Wu J, et al. Among authors: losiewicz md. Environ Toxicol. 2019 Oct;34(10):1074-1084. doi: 10.1002/tox.22808. Epub 2019 Jun 3. Environ Toxicol. 2019. PMID: 31157505
A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells.
Zhao Z, Ma X, Shelton SD, Sung DC, Li M, Hernandez D, Zhang M, Losiewicz MD, Chen Y, Pertsemlidis A, Yu X, Liu Y, Du L. Zhao Z, et al. Among authors: losiewicz md. Oncotarget. 2016 Nov 29;7(48):79372-79387. doi: 10.18632/oncotarget.12676. Oncotarget. 2016. PMID: 27764804 Free PMC article.