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Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles.
Hatit MZC, Lokugamage MP, Dobrowolski CN, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: loughrey d. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. Nat Nanotechnol. 2022. PMID: 35132167 Free PMC article.
Using Large Datasets to Understand Nanotechnology.
Paunovska K, Loughrey D, Sago CD, Langer R, Dahlman JE. Paunovska K, et al. Among authors: loughrey d. Adv Mater. 2019 Oct;31(43):e1902798. doi: 10.1002/adma.201902798. Epub 2019 Aug 20. Adv Mater. 2019. PMID: 31429126 Free PMC article. Review.
Increased PIP3 activity blocks nanoparticle mRNA delivery.
Paunovska K, Da Silva Sanchez A, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman JE. Paunovska K, et al. Among authors: loughrey d. Sci Adv. 2020 Jul 22;6(30):eaba5672. doi: 10.1126/sciadv.aba5672. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32743074 Free PMC article.
Non-liver mRNA Delivery.
Loughrey D, Dahlman JE. Loughrey D, et al. Acc Chem Res. 2022 Jan 4;55(1):13-23. doi: 10.1021/acs.accounts.1c00601. Epub 2021 Dec 3. Acc Chem Res. 2022. PMID: 34859663 Review.
Drug delivery systems for RNA therapeutics.
Paunovska K, Loughrey D, Dahlman JE. Paunovska K, et al. Among authors: loughrey d. Nat Rev Genet. 2022 May;23(5):265-280. doi: 10.1038/s41576-021-00439-4. Epub 2022 Jan 4. Nat Rev Genet. 2022. PMID: 34983972 Free PMC article. Review.
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver.
Sago CD, Lokugamage MP, Loughrey D, Lindsay KE, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Echeverri ES, Fitzgerald JP, Gan Z, Gamboa L, Paunovska K, Sanhueza CA, Hatit MZC, Finn MG, Santangelo PJ, Dahlman JE. Sago CD, et al. Among authors: loughrey d. Nat Biomed Eng. 2022 Feb;6(2):157-167. doi: 10.1038/s41551-022-00847-9. Epub 2022 Feb 21. Nat Biomed Eng. 2022. PMID: 35190679
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery.
Da Silva Sanchez AJ, Dobrowolski C, Cristian A, Echeverri ES, Zhao K, Hatit MZC, Loughrey D, Paunovska K, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: loughrey d. Nano Lett. 2022 Jun 22;22(12):4822-4830. doi: 10.1021/acs.nanolett.2c01133. Epub 2022 Jun 7. Nano Lett. 2022. PMID: 35671473
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery.
Dobrowolski C, Paunovska K, Schrader Echeverri E, Loughrey D, Da Silva Sanchez AJ, Ni H, Hatit MZC, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE. Dobrowolski C, et al. Among authors: loughrey d. Nat Nanotechnol. 2022 Aug;17(8):871-879. doi: 10.1038/s41565-022-01146-9. Epub 2022 Jun 30. Nat Nanotechnol. 2022. PMID: 35768613
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.
Ni H, Hatit MZC, Zhao K, Loughrey D, Lokugamage MP, Peck HE, Cid AD, Muralidharan A, Kim Y, Santangelo PJ, Dahlman JE. Ni H, et al. Among authors: loughrey d. Nat Commun. 2022 Aug 15;13(1):4766. doi: 10.1038/s41467-022-32281-5. Nat Commun. 2022. PMID: 35970837 Free PMC article.
36 results