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69 results

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Page 1
B cells in chronic obstructive pulmonary disease: moving to center stage.
Polverino F, Seys LJ, Bracke KR, Owen CA. Polverino F, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. doi: 10.1152/ajplung.00304.2016. Epub 2016 Aug 19. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27542809 Free PMC article. Review.
Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). ...
Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pul …
BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza.
Soni S, Yildiz S, Allen EK, Petersen H, Peeples M, El Zahed S, Rosas L, Anang V, Antonescu L, Nho RS, Mora AL, Horowitz JC, Rojas M, Medina RA, Thomas PG, García-Sastre A, Tesfaigzi Y, Mebratu YA. Soni S, et al. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2424367122. doi: 10.1073/pnas.2424367122. Epub 2025 Jul 8. Proc Natl Acad Sci U S A. 2025. PMID: 40627391 Free PMC article.
Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, and influenza-infected human cohor …
Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We …
Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).
Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA. Laucho-Contreras ME, et al. Expert Opin Ther Targets. 2016 Jul;20(7):869-83. doi: 10.1517/14728222.2016.1139084. Epub 2016 Feb 11. Expert Opin Ther Targets. 2016. PMID: 26781659 Free PMC article. Review.
CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) is associated with CC16 deficiency. Herein, we explored whether CC16 is a therapeutic target for COPD. ...Additional studies are necessary to …
CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) i …
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of beta-Catenin.
Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X. Jiang Z, et al. Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC. Am J Respir Crit Care Med. 2016. PMID: 26862784 Free PMC article.
RATIONALE: A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, the mechanisms by which FAM13A contributes to COPD susceptibility are unkn …
RATIONALE: A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary …
Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic obstructive pulmonary disease (COPD).
Daheshia M. Daheshia M. Curr Med Res Opin. 2005 Apr;21(4):587-94. doi: 10.1185/030079905X41417. Curr Med Res Opin. 2005. PMID: 15899108 Review.
BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) is increasing worldwide and is ranked as the fourth most common cause of death in the United States. ...SCOPE: This review discusses the structural features of MMPs, their pul …
BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) is increasing worldwide and is ranked …
Early Endotyping: A Chance for Intervention in Chronic Obstructive Pulmonary Disease.
Petersen H, Vazquez Guillamet R, Meek P, Sood A, Tesfaigzi Y. Petersen H, et al. Am J Respir Cell Mol Biol. 2018 Jul;59(1):13-17. doi: 10.1165/rcmb.2018-0002PS. Am J Respir Cell Mol Biol. 2018. PMID: 29522352 Free PMC article.
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but subphenotyping the various disease subtypes has been difficult. ...Together with understanding of the involved molecular pathways that lead t …
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but subpheno …
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA. Polverino F, et al. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1254-1267. doi: 10.1164/rccm.201707-1331OC. Am J Respir Crit Care Med. 2018. PMID: 29750543 Free PMC article.
RATIONALE: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by leukocytes and epithelial cells in health, but its contribution to the pathogenesis of chronic obstructive pulmonary disease (COPD) is unknown. OBJECTIVES: To determine whe …
RATIONALE: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by leukocytes and epithelial cells in health, but its contribut …
DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough.
Pelleg A, Xu F, Zhuang J, Undem B, Burnstock G. Pelleg A, et al. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619877960. doi: 10.1177/1753466619877960. Ther Adv Respir Dis. 2019. PMID: 31558105 Free PMC article.
BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) plays important mechanistic roles in pulmonary disorders in general and chronic obstructive pulmonary disease (COPD) and cough in particular. ...The activation of these receptors by ATP t …
BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) plays important mechanistic roles in pulmonary disorders in general and …
A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease.
Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, Divo M, Pinto-Plata V, Chetta A, Tesfaigzi Y, Celli BR, Owen CA. Polverino F, et al. Am J Respir Crit Care Med. 2017 Jun 1;195(11):1464-1476. doi: 10.1164/rccm.201609-1765OC. Am J Respir Crit Care Med. 2017. PMID: 28085500 Free PMC article.
RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. ...Treating mice with enalapril attenuated CS-induced increases in urinary albumi …
RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of …
Animal models of chronic bronchitis and their relevance to studies of particle-induced disease.
Nikula KJ, Green FH. Nikula KJ, et al. Inhal Toxicol. 2000;12 Suppl 4:123-53. doi: 10.1080/089583700750019549. Inhal Toxicol. 2000. PMID: 12881890 Review.
Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis o …
Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled …
69 results