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1987 1
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1999 1
2000 3
2002 3
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2005 3
2006 1
2007 2
2008 1
2011 2
2012 1
2013 5
2014 4
2015 7
2016 12
2017 8
2018 8
2019 2
2021 1
2022 1
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65 results
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Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Cloonan SM, et al. Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11. Nat Med. 2016. PMID: 26752519 Free PMC article.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. ...Mice treated with a mitochondrial iron chelator or mice fed a low-iron diet were protected from CS-induced COPD. Mitochondrial i
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants
B cells in chronic obstructive pulmonary disease: moving to center stage.
Polverino F, Seys LJ, Bracke KR, Owen CA. Polverino F, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. doi: 10.1152/ajplung.00304.2016. Epub 2016 Aug 19. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27542809 Free PMC article. Review.
Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). Although research studies focused initially on the contributions of the innate immune system to the
Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pul
DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough.
Pelleg A, Xu F, Zhuang J, Undem B, Burnstock G. Pelleg A, et al. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619877960. doi: 10.1177/1753466619877960. Ther Adv Respir Dis. 2019. PMID: 31558105 Free PMC article.
BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) plays important mechanistic roles in pulmonary disorders in general and chronic obstructive pulmonary disease (COPD) and cough in particular. ...CONCLUSIONS: These results indicate …
BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) plays important mechanistic roles in pulmonary disorders in general and …
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.
Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X. Jiang Z, et al. Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC. Am J Respir Crit Care Med. 2016. PMID: 26862784 Free PMC article.
RATIONALE: A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, the mechanisms by which FAM13A contributes to COPD susceptib …
RATIONALE: A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA. Polverino F, et al. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1254-1267. doi: 10.1164/rccm.201707-1331OC. Am J Respir Crit Care Med. 2018. PMID: 29750543 Free PMC article.
RATIONALE: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by leukocytes and epithelial cells in health, but its contribution to the pathogenesis of chronic obstructive pulmonary disease (COPD) is unknown. OBJECTIVES: To determ …
RATIONALE: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by leukocytes and epithelial cells in health, but its contribut …
Early Endotyping: A Chance for Intervention in Chronic Obstructive Pulmonary Disease.
Petersen H, Vazquez Guillamet R, Meek P, Sood A, Tesfaigzi Y. Petersen H, et al. Am J Respir Cell Mol Biol. 2018 Jul;59(1):13-17. doi: 10.1165/rcmb.2018-0002PS. Am J Respir Cell Mol Biol. 2018. PMID: 29522352 Free PMC article.
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but subphenotyping the various disease subtypes has been difficult. One reason may be that current efforts focused on studying COPD
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but s
A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease.
Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, Divo M, Pinto-Plata V, Chetta A, Tesfaigzi Y, Celli BR, Owen CA. Polverino F, et al. Am J Respir Crit Care Med. 2017 Jun 1;195(11):1464-1476. doi: 10.1164/rccm.201609-1765OC. Am J Respir Crit Care Med. 2017. PMID: 28085500 Free PMC article.
RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia. ...The efficacy of enalapril on pulmonary and renal lesions was ass …
RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indica …
Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).
Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA. Laucho-Contreras ME, et al. Expert Opin Ther Targets. 2016 Jul;20(7):869-83. doi: 10.1517/14728222.2016.1139084. Epub 2016 Feb 11. Expert Opin Ther Targets. 2016. PMID: 26781659 Free PMC article. Review.
CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) is associated with CC16 deficiency. ...Additional studies are necessary to assess the efficacy of therapies aimed at restoring airway …
CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD
Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic obstructive pulmonary disease (COPD).
Daheshia M. Daheshia M. Curr Med Res Opin. 2005 Apr;21(4):587-94. doi: 10.1185/030079905X41417. Curr Med Res Opin. 2005. PMID: 15899108 Review.
BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) is increasing worldwide and is ranked as the fourth most common cause of death in the United States. ...SCOPE: This review discusses the structural features of MMPs, their …
BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) is increasing worldwide and is …
Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques.
Chand HS, Vazquez-Guillamet R, Royer C, Rudolph K, Mishra N, Singh SP, Hussain SS, Barrett E, Callen S, Byrareddy SN, Guillamet MCV, Abukhalaf J, Sheybani A, Exil V, Raizada V, Agarwal H, Nair M, Villinger F, Buch S, Sopori M. Chand HS, et al. J Clin Invest. 2018 Dec 3;128(12):5428-5433. doi: 10.1172/JCI121935. Epub 2018 Nov 5. J Clin Invest. 2018. PMID: 30277472 Free PMC article.
In the era of combined antiretroviral therapy (cART), lung diseases such as chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) are common among persons living with HIV (PLWH), particularly smokers. ...We conclude tha …
In the era of combined antiretroviral therapy (cART), lung diseases such as chronic bronchitis (CB) and chronic obstructive
65 results