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Control of apoptosis by p53.
Fridman JS, Lowe SW. Fridman JS, et al. Among authors: lowe sw. Oncogene. 2003 Dec 8;22(56):9030-40. doi: 10.1038/sj.onc.1207116. Oncogene. 2003. PMID: 14663481 Review.
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Bywater MJ, Poortinga G, Sanij E, Hein N, Peck A, Cullinane C, Wall M, Cluse L, Drygin D, Anderes K, Huser N, Proffitt C, Bliesath J, Haddach M, Schwaebe MK, Ryckman DM, Rice WG, Schmitt C, Lowe SW, Johnstone RW, Pearson RB, McArthur GA, Hannan RD. Bywater MJ, et al. Among authors: lowe sw. Cancer Cell. 2012 Jul 10;22(1):51-65. doi: 10.1016/j.ccr.2012.05.019. Cancer Cell. 2012. PMID: 22789538 Free PMC article.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. Feng Z, et al. Among authors: lowe s. Cancer Res. 2007 Apr 1;67(7):3043-53. doi: 10.1158/0008-5472.CAN-06-4149. Cancer Res. 2007. PMID: 17409411
Suppression of tumorigenesis by the p53 target PUMA.
Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW. Hemann MT, et al. Among authors: lowe sw. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9333-8. doi: 10.1073/pnas.0403286101. Epub 2004 Jun 10. Proc Natl Acad Sci U S A. 2004. PMID: 15192153 Free PMC article.
Tumor suppressive functions of p53.
Zilfou JT, Lowe SW. Zilfou JT, et al. Among authors: lowe sw. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a001883. doi: 10.1101/cshperspect.a001883. Cold Spring Harb Perspect Biol. 2009. PMID: 20066118 Free PMC article. Review.
Dissecting p53 tumor suppressor functions in vivo.
Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW. Schmitt CA, et al. Among authors: lowe sw. Cancer Cell. 2002 Apr;1(3):289-98. doi: 10.1016/s1535-6108(02)00047-8. Cancer Cell. 2002. PMID: 12086865
Apoptosis: a link between cancer genetics and chemotherapy.
Johnstone RW, Ruefli AA, Lowe SW. Johnstone RW, et al. Among authors: lowe sw. Cell. 2002 Jan 25;108(2):153-64. doi: 10.1016/s0092-8674(02)00625-6. Cell. 2002. PMID: 11832206 Review.
PML is a direct p53 target that modulates p53 effector functions.
de Stanchina E, Querido E, Narita M, Davuluri RV, Pandolfi PP, Ferbeyre G, Lowe SW. de Stanchina E, et al. Among authors: lowe sw. Mol Cell. 2004 Feb 27;13(4):523-35. doi: 10.1016/s1097-2765(04)00062-0. Mol Cell. 2004. PMID: 14992722
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW. Hirao A, et al. Among authors: lowe sw. Mol Cell Biol. 2002 Sep;22(18):6521-32. doi: 10.1128/mcb.22.18.6521-6532.2002. Mol Cell Biol. 2002. PMID: 12192050 Free PMC article.
Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.
Laska MJ, Lowe SW, Zender L, Hearn S, Vogel U, Jensen UB, Bric A, Nexø BA. Laska MJ, et al. Among authors: lowe sw. Mol Carcinog. 2009 Sep;48(9):832-42. doi: 10.1002/mc.20528. Mol Carcinog. 2009. PMID: 19263435 Free PMC article.
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