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Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis.
Lu D, Insel PA. Lu D, et al. Am J Physiol Cell Physiol. 2014 May 1;306(9):C779-88. doi: 10.1152/ajpcell.00381.2013. Epub 2013 Dec 18. Am J Physiol Cell Physiol. 2014. PMID: 24352335 Free PMC article. Review.
Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.
Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Lu D, et al. Mol Pharmacol. 2013 Dec;84(6):787-93. doi: 10.1124/mol.113.087742. Epub 2013 Oct 1. Mol Pharmacol. 2013. PMID: 24085841 Free PMC article.
Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts.
Lu D, Insel PA. Lu D, et al. J Biol Chem. 2013 Jun 28;288(26):19040-9. doi: 10.1074/jbc.M113.466102. Epub 2013 May 15. J Biol Chem. 2013. PMID: 23677997 Free PMC article.
ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors.
Lu D, Soleymani S, Madakshire R, Insel PA. Lu D, et al. FASEB J. 2012 Jun;26(6):2580-91. doi: 10.1096/fj.12-204677. Epub 2012 Mar 13. FASEB J. 2012. PMID: 22415310 Free PMC article.
Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors.
Braun OO, Lu D, Aroonsakool N, Insel PA. Braun OO, et al. Among authors: lu d. J Mol Cell Cardiol. 2010 Sep;49(3):362-9. doi: 10.1016/j.yjmcc.2010.05.001. Epub 2010 May 13. J Mol Cell Cardiol. 2010. PMID: 20471392 Free PMC article.
cAMP and Epac in the regulation of tissue fibrosis.
Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. Insel PA, et al. Among authors: lu d. Br J Pharmacol. 2012 May;166(2):447-56. doi: 10.1111/j.1476-5381.2012.01847.x. Br J Pharmacol. 2012. PMID: 22233238 Free PMC article. Review.
Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival.
Boffa DJ, Graf RP, Salazar MC, Hoag J, Lu D, Krupa R, Louw J, Dugan L, Wang Y, Landers M, Suraneni M, Greene SB, MagaƱa M, Makani S, Bazhenova L, Dittamore RV, Nieva J. Boffa DJ, et al. Among authors: lu d. Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1139-1145. doi: 10.1158/1055-9965.EPI-17-0120. Epub 2017 Apr 26. Cancer Epidemiol Biomarkers Prev. 2017. PMID: 28446544 Free PMC article.
Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer.
Scher HI, Graf RP, Schreiber NA, McLaughlin B, Jendrisak A, Wang Y, Lee J, Greene S, Krupa R, Lu D, Bamford P, Louw JE, Dugan L, Vargas HA, Fleisher M, Landers M, Heller G, Dittamore R. Scher HI, et al. Among authors: lu d. Cancer Res. 2017 Oct 15;77(20):5687-5698. doi: 10.1158/0008-5472.CAN-17-1353. Epub 2017 Aug 17. Cancer Res. 2017. PMID: 28819021 Free PMC article.
Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness.
Lopez T, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M. Lopez T, et al. Among authors: lu d. J Med Food. 2014 Dec;17(12):1314-21. doi: 10.1089/jmf.2013.0190. J Med Food. 2014. PMID: 25058464 Free PMC article.
Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer.
Scher HI, Lu D, Schreiber NA, Louw J, Graf RP, Vargas HA, Johnson A, Jendrisak A, Bambury R, Danila D, McLaughlin B, Wahl J, Greene SB, Heller G, Marrinucci D, Fleisher M, Dittamore R. Scher HI, et al. Among authors: lu d. JAMA Oncol. 2016 Nov 1;2(11):1441-1449. doi: 10.1001/jamaoncol.2016.1828. JAMA Oncol. 2016. PMID: 27262168 Free PMC article.
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