Lu GH - Search Results

1

2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.

Klutchko SR, Hamby JM, Boschelli DH, Wu Z, Kraker AJ, Amar AM, Hartl BG, Shen C, Klohs WD, Steinkampf RW, Driscoll DL, Nelson JM, Elliott WL, Roberts BJ, Stoner CL, Vincent PW, Dykes DJ, Panek RL, Lu GH, Major TC, Dahring TK, Hallak H, Bradford LA, Showalter HD, Doherty AM. Klutchko SR, et al. Among authors: lu gh. J Med Chem. 1998 Aug 13;41(17):3276-92. doi: 10.1021/jm9802259. J Med Chem. 1998. PMID: 9703473

2

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.

Sircar I, Winters RT, Quin J 3rd, Lu GH, Major TC, Panek RL. Sircar I, et al. Among authors: lu gh. J Med Chem. 1993 Jun 11;36(12):1735-45. doi: 10.1021/jm00064a007. J Med Chem. 1993. PMID: 8510101

3

Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-beta receptor.

Ramalingam K, Eaton SR, Cody WL, Lu GH, Panek RL, Waite LA, Decker SJ, Keiser JA, Doherty AM. Ramalingam K, et al. Among authors: lu gh. Bioorg Med Chem. 1995 Sep;3(9):1263-72. doi: 10.1016/0968-0896(95)00112-t. Bioorg Med Chem. 1995. PMID: 8564419

4

Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.

Showalter HD, Sercel AD, Leja BM, Wolfangel CD, Ambroso LA, Elliott WL, Fry DW, Kraker AJ, Howard CT, Lu GH, Moore CW, Nelson JM, Roberts BJ, Vincent PW, Denny WA, Thompson AM. Showalter HD, et al. Among authors: lu gh. J Med Chem. 1997 Feb 14;40(4):413-26. doi: 10.1021/jm960689b. J Med Chem. 1997. PMID: 9046331

5

Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor.

Dahring TK, Lu GH, Hamby JM, Batley BL, Kraker AJ, Panek RL. Dahring TK, et al. Among authors: lu gh. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56. J Pharmacol Exp Ther. 1997. PMID: 9190882

6

Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.

Hamby JM, Connolly CJ, Schroeder MC, Winters RT, Showalter HD, Panek RL, Major TC, Olsewski B, Ryan MJ, Dahring T, Lu GH, Keiser J, Amar A, Shen C, Kraker AJ, Slintak V, Nelson JM, Fry DW, Bradford L, Hallak H, Doherty AM. Hamby JM, et al. Among authors: lu gh. J Med Chem. 1997 Jul 18;40(15):2296-303. doi: 10.1021/jm970367n. J Med Chem. 1997. PMID: 9240345

7

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.

Panek RL, Lu GH, Klutchko SR, Batley BL, Dahring TK, Hamby JM, Hallak H, Doherty AM, Keiser JA. Panek RL, et al. Among authors: lu gh. J Pharmacol Exp Ther. 1997 Dec;283(3):1433-44. J Pharmacol Exp Ther. 1997. PMID: 9400019

8

Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor.

Batley BL, Doherty AM, Hamby JM, Lu GH, Keller P, Dahring TK, Hwang O, Crickard K, Panek RL. Batley BL, et al. Among authors: lu gh. Life Sci. 1998;62(2):143-50. doi: 10.1016/s0024-3205(97)01060-6. Life Sci. 1998. PMID: 9488112

9

In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase.

Panek RL, Lu GH, Dahring TK, Batley BL, Connolly C, Hamby JM, Brown KJ. Panek RL, et al. Among authors: lu gh. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77. J Pharmacol Exp Ther. 1998. PMID: 9655904

10

Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity.

Eaton SR, Cody WL, Doherty AM, Holland DR, Panek RL, Lu GH, Dahring TK, Rose DR. Eaton SR, et al. Among authors: lu gh. J Med Chem. 1998 Oct 22;41(22):4329-42. doi: 10.1021/jm9802766. J Med Chem. 1998. PMID: 9784108

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