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20,720 results
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In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.
Huang L, Lu J, Wroblewski VJ, Beals JM, Riggin RM. Huang L, et al. Among authors: lu j. Anal Chem. 2005 Mar 1;77(5):1432-9. doi: 10.1021/ac0494174. Anal Chem. 2005. PMID: 15732928
IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.
Lu J, Witcher DR, White MA, Wang X, Huang L, Rathnachalam R, Beals JM, Kuhstoss S. Lu J, et al. Biochemistry. 2005 Aug 23;44(33):11106-14. doi: 10.1021/bi0505464. Biochemistry. 2005. PMID: 16101294
Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.
Datta-Mannan A, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2012 Mar-Apr;4(2):267-73. doi: 10.4161/mabs.4.2.19364. Epub 2012 Mar 1. MAbs. 2012. PMID: 22377715 Free PMC article.
FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.
Datta-Mannan A, Chow CK, Dickinson C, Driver D, Lu J, Witcher DR, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. Drug Metab Dispos. 2012 Aug;40(8):1545-55. doi: 10.1124/dmd.112.045864. Epub 2012 May 14. Drug Metab Dispos. 2012. PMID: 22584253
Qualification of a free ligand assay in the presence of anti-ligand antibody Fab fragments.
Hansen RJ, Brown RM, Lu J, Wroblewski VJ. Hansen RJ, et al. Among authors: lu j. MAbs. 2013 Mar-Apr;5(2):288-96. doi: 10.4161/mabs.23508. Epub 2013 Feb 8. MAbs. 2013. PMID: 23396084 Free PMC article.
Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor (MET).
Gruver AM, Liu L, Vaillancourt P, Yan SC, Cook JD, Roseberry Baker JA, Felke EM, Lacy ME, Marchal CC, Szpurka H, Holzer TR, Rhoads EK, Zeng W, Wortinger MA, Lu J, Chow CK, Denning IJ, Beuerlein G, Davies J, Hanson JC, Credille KM, Wijayawardana SR, Schade AE. Gruver AM, et al. Among authors: lu j. Histopathology. 2014 Dec;65(6):879-96. doi: 10.1111/his.12510. Epub 2014 Oct 6. Histopathology. 2014. PMID: 25039923
LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth.
Liu L, Zeng W, Wortinger MA, Yan SB, Cornwell P, Peek VL, Stephens JR, Tetreault JW, Xia J, Manro JR, Credille KM, Ballard DW, Brown-Augsburger P, Wacheck V, Chow CK, Huang L, Wang Y, Denning I, Davies J, Tang Y, Vaillancourt P, Lu J. Liu L, et al. Among authors: lu j. Clin Cancer Res. 2014 Dec 1;20(23):6059-70. doi: 10.1158/1078-0432.CCR-14-0543. Epub 2014 Sep 17. Clin Cancer Res. 2014. PMID: 25231402
Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.
Datta-Mannan A, Thangaraju A, Leung D, Tang Y, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2015;7(3):483-93. doi: 10.1080/19420862.2015.1016696. MAbs. 2015. PMID: 25695748 Free PMC article.
The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.
Datta-Mannan A, Lu J, Witcher DR, Leung D, Tang Y, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2015;7(6):1084-93. doi: 10.1080/19420862.2015.1075109. Epub 2015 Sep 4. MAbs. 2015. PMID: 26337808 Free PMC article.
Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure.
Chow CK, Allan BW, Chai Q, Atwell S, Lu J. Chow CK, et al. Among authors: lu j. Mol Pharm. 2016 Mar 7;13(3):915-23. doi: 10.1021/acs.molpharmaceut.5b00817. Epub 2016 Feb 18. Mol Pharm. 2016. PMID: 26849155
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