Lu KP - Search Results

Year	Number of Results
1990	2
1991	1
1992	2
1993	4
1994	2
1995	3
1996	2
1997	3
1998	3
1999	4
2000	9
2001	12
2002	10
2003	11
2004	5
2005	7
2006	10
2007	8
2008	6
2009	4
2010	5
2011	11
2012	14
2013	3
2014	5
2015	10
2016	9
2017	10
2018	10
2019	10
2020	6
2021	9
2022	2
2023	5
2024	10
2025	4

1

Retraction note: Efficacy and safety analysis of transarterial chemoembolization and transarterial radioembolization in advanced hepatocellular carcinoma descending hepatectomy.

Feng R, Cheng DX, Song T, Chen L, Lu KP. Feng R, et al. Among authors: lu kp. World J Gastrointest Surg. 2025 May 27;17(5):105113. doi: 10.4240/wjgs.v17.i5.105113. World J Gastrointest Surg. 2025. PMID: 40502500 Free PMC article.

2

The Central Role of Pin1 in Age-Related Cancer Signaling Pathways.

Xie G, Okuda S, Gao JY, Wu T, Jeong J, Lu KP, Zhou XZ. Xie G, et al. Among authors: lu kp. Semin Cancer Biol. 2025 May 22:S1044-579X(25)00072-0. doi: 10.1016/j.semcancer.2025.05.011. Online ahead of print. Semin Cancer Biol. 2025. PMID: 40412492 Free article. Review.

3

Covalent cross-linking approaches for all-trans retinoic acid-loaded thermo-responsive hydrogels.

Mei X, Stewart RC, Zhou XZ, Lu KP, Gillies ER. Mei X, et al. Among authors: lu kp. Soft Matter. 2025 Jun 11;21(23):4739-4750. doi: 10.1039/d5sm00228a. Soft Matter. 2025. PMID: 40406999

4

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia.

Amabebe E, Huang Z, Jash S, Krishnan B, Cheng S, Nakashima A, Li Y, Li Z, Wang R, Menon R, Zhou XZ, Lu KP, Sharma S. Amabebe E, et al. Among authors: lu kp. Biomedicines. 2024 Dec 26;13(1):29. doi: 10.3390/biomedicines13010029. Biomedicines. 2024. PMID: 39857613 Free PMC article. Review.

5

Corrigendum to "Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells" [J Hazard Mater 419 (2021) 126378].

Zheng F, Li Y, Zhang F, Sun Y, Zheng C, Luo Z, Wang YL, Aschner M, Zheng H, Lin L, Cai P, Shao W, Guo Z, Zheng M, Zhou XZ, Lu KP, Wu S, Li H. Zheng F, et al. Among authors: lu kp. J Hazard Mater. 2025 Jan 5;481:136590. doi: 10.1016/j.jhazmat.2024.136590. Epub 2024 Nov 21. J Hazard Mater. 2025. PMID: 39572344 No abstract available.

6

Corrigendum to "Pin1 inhibition reverses the acquired resistance of human hepatocellular carcinoma cells to Regorafenib via the Gli1/Snail/E-cadherin pathway" [Cancer Lett. 444 (2019) 82-93].

Wang J, Zhang N, Han Q, Lu W, Wang L, Yang D, Zheng M, Zhang Z, Liu H, Lee TH, Zhou XZ, Lu KP. Wang J, et al. Among authors: lu kp. Cancer Lett. 2024 Nov 1;604:217257. doi: 10.1016/j.canlet.2024.217257. Epub 2024 Sep 27. Cancer Lett. 2024. PMID: 39333006 Free article. No abstract available.

7

Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery.

Lu KP, Zhou XZ. Lu KP, et al. Sci Signal. 2024 Jun 18;17(841):eadi8743. doi: 10.1126/scisignal.adi8743. Epub 2024 Jun 18. Sci Signal. 2024. PMID: 38889227 Free PMC article. Review.

8

The role of the master cancer regulator Pin1 in the development and treatment of cancer.

Stewart R, Sharma S, Wu T, Okuda S, Xie G, Zhou XZ, Shilton B, Lu KP. Stewart R, et al. Among authors: lu kp. Front Cell Dev Biol. 2024 Apr 30;12:1343938. doi: 10.3389/fcell.2024.1343938. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38745861 Free PMC article. Review.

9

Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation.

Jeong J, Usman M, Li Y, Zhou XZ, Lu KP. Jeong J, et al. Among authors: lu kp. Cells. 2024 Apr 23;13(9):731. doi: 10.3390/cells13090731. Cells. 2024. PMID: 38727267 Free PMC article. Review.

10

Correction: Pin1 Inhibition Sensitizes Chemotherapy in Gastric Cancer Cells by Targeting Stem Cell-like Traits and Multiple Biomarkers.

Zhang ZZ, Yu WX, Zheng M, Liao XH, Wang JC, Yang DY, Lu WX, Wang L, Zhang S, Liu HK, Zhou XZ, Lu KP. Zhang ZZ, et al. Among authors: lu kp. Mol Cancer Ther. 2024 May 2;23(5):743. doi: 10.1158/1535-7163.MCT-24-0063. Mol Cancer Ther. 2024. PMID: 38693904 No abstract available.

11

The role of the Pin1-cis P-tau axis in the development and treatment of vascular contribution to cognitive impairment and dementia and preeclampsia.

Qiu C, Li Z, Leigh DA, Duan B, Stucky JE, Kim N, Xie G, Lu KP, Zhou XZ. Qiu C, et al. Among authors: lu kp. Front Cell Dev Biol. 2024 Apr 2;12:1343962. doi: 10.3389/fcell.2024.1343962. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38628595 Free PMC article. Review.

12

Reciprocal antagonism of PIN1-APC/C^CDH1 governs mitotic protein stability and cell cycle entry.

Ke S, Dang F, Wang L, Chen JY, Naik MT, Li W, Thavamani A, Kim N, Naik NM, Sui H, Tang W, Qiu C, Koikawa K, Batalini F, Stern Gatof E, Isaza DA, Patel JM, Wang X, Clohessy JG, Heng YJ, Lahav G, Liu Y, Gray NS, Zhou XZ, Wei W, Wulf GM, Lu KP. Ke S, et al. Among authors: lu kp. Nat Commun. 2024 Apr 15;15(1):3220. doi: 10.1038/s41467-024-47427-w. Nat Commun. 2024. PMID: 38622115 Free PMC article.

13

Efficacy of transjugular intrahepatic portosystemic shunts in treating cirrhotic esophageal-gastric variceal bleeding.

Hu XG, Dai JJ, Lu J, Li G, Wang JM, Deng Y, Feng R, Lu KP. Hu XG, et al. Among authors: lu kp. World J Gastrointest Surg. 2024 Feb 27;16(2):471-480. doi: 10.4240/wjgs.v16.i2.471. World J Gastrointest Surg. 2024. PMID: 38463371 Free PMC article.

14

Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia.

Jash S, Banerjee S, Cheng S, Wang B, Qiu C, Kondo A, Ernerudh J, Zhou XZ, Lu KP, Sharma S. Jash S, et al. Among authors: lu kp. Nat Commun. 2023 Sep 5;14(1):5414. doi: 10.1038/s41467-023-41144-6. Nat Commun. 2023. PMID: 37669931 Free PMC article.

15

Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies.

Wang R, Lu KP, Zhou XZ. Wang R, et al. Among authors: lu kp. J Neurochem. 2023 Sep;166(6):904-914. doi: 10.1111/jnc.15909. Epub 2023 Aug 28. J Neurochem. 2023. PMID: 37638382 Review.

16

Author Correction: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

Nechama M, Kwon J, Wei S, Tun-Kyi A, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP. Nechama M, et al. Among authors: lu kp. Nat Commun. 2023 Jun 19;14(1):3622. doi: 10.1038/s41467-023-39297-5. Nat Commun. 2023. PMID: 37336880 Free PMC article. No abstract available.

17

Efficacy and safety analysis of transarterial chemoembolization and transarterial radioembolization in advanced hepatocellular carcinoma descending hepatectomy.

Feng R, Cheng DX, Song T, Chen L, Lu KP. Feng R, et al. Among authors: lu kp. World J Gastrointest Surg. 2023 Apr 27;15(4):687-697. doi: 10.4240/wjgs.v15.i4.687. World J Gastrointest Surg. 2023. Retraction in: World J Gastrointest Surg. 2025 May 27;17(5):105113. doi: 10.4240/wjgs.v17.i5.105113. PMID: 37206075 Free PMC article. Retracted.

18

Reciprocal inhibition of PIN1 and APC/C_CDH1 controls timely G1/S transition and creates therapeutic vulnerability.

Ke S, Dang F, Wang L, Chen JY, Naik MT, Thavamani A, Liu Y, Li W, Kim N, Naik NM, Sui H, Tang W, Qiu C, Koikawa K, Batalini F, Wang X, Clohessy JG, Heng YJ, Lahav G, Gray NS, Zho XZ, Wei W, Wulf GM, Lu KP. Ke S, et al. Among authors: lu kp. Res Sq [Preprint]. 2023 Jan 19:rs.3.rs-2447544. doi: 10.21203/rs.3.rs-2447544/v1. Res Sq. 2023. PMID: 36711754 Free PMC article. Preprint.

19

Erratum for Wang et al., "Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin".

Wang HY, Chung CR, Chen CJ, Lu KP, Tseng YJ, Chang TH, Wu MH, Huang WT, Lin TW, Liu TP, Lee TY, Horng JT, Lu JJ. Wang HY, et al. Among authors: lu kp. Microbiol Spectr. 2022 Feb 23;10(1):e0261021. doi: 10.1128/spectrum.02610-21. Epub 2022 Jan 19. Microbiol Spectr. 2022. PMID: 35044194 Free PMC article. No abstract available.

20

Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin.

Wang HY, Chung CR, Chen CJ, Lu KP, Tseng YJ, Chang TH, Wu MH, Huang WT, Lin TW, Liu TP, Lee TY, Horng JT, Lu JJ. Wang HY, et al. Among authors: lu kp. Microbiol Spectr. 2021 Dec 22;9(3):e0091321. doi: 10.1128/Spectrum.00913-21. Epub 2021 Nov 10. Microbiol Spectr. 2021. PMID: 34756065 Free PMC article.

21

Induction of IL-6Rα by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance in hepatocellular carcinoma.

Dai Z, Wang X, Peng R, Zhang B, Han Q, Lin J, Wang J, Lin J, Jiang M, Liu H, Lee TH, Lu KP, Zheng M. Dai Z, et al. Among authors: lu kp. Cancer Lett. 2022 Jan 1;524:161-171. doi: 10.1016/j.canlet.2021.10.024. Epub 2021 Oct 20. Cancer Lett. 2022. PMID: 34687791

22

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.

Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Koikawa K, et al. Among authors: lu kp. Cell. 2021 Sep 2;184(18):4753-4771.e27. doi: 10.1016/j.cell.2021.07.020. Epub 2021 Aug 12. Cell. 2021. PMID: 34388391 Free PMC article.

23

Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells.

Zheng F, Li Y, Zhang F, Sun Y, Zheng C, Luo Z, Wang YL, Aschner M, Zheng H, Lin L, Cai P, Shao W, Guo Z, Zheng M, Zhou XZ, Lu KP, Wu S, Li H. Zheng F, et al. Among authors: lu kp. J Hazard Mater. 2021 Oct 5;419:126378. doi: 10.1016/j.jhazmat.2021.126378. Epub 2021 Jun 12. J Hazard Mater. 2021. PMID: 34175703

24

Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice.

Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, Tsai CY, Bassal MA, Herbert MK, Washida K, Angeli P, Kozono S, Stucky JE, Baxley S, Lin YM, Sun Y, Rotenberg A, Caldarone BJ, Bigio EH, Chen X, Tenen DG, Zeidel M, Lo EH, Zhou XZ, Lu KP. Qiu C, et al. Among authors: lu kp. Sci Transl Med. 2021 Jun 2;13(596):eaaz7615. doi: 10.1126/scitranslmed.aaz7615. Sci Transl Med. 2021. PMID: 34078745 Free PMC article.

25

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.

Dubiella C, Pinch BJ, Koikawa K, Zaidman D, Poon E, Manz TD, Nabet B, He S, Resnick E, Rogel A, Langer EM, Daniel CJ, Seo HS, Chen Y, Adelmant G, Sharifzadeh S, Ficarro SB, Jamin Y, Martins da Costa B, Zimmerman MW, Lian X, Kibe S, Kozono S, Doctor ZM, Browne CM, Yang A, Stoler-Barak L, Shah RB, Vangos NE, Geffken EA, Oren R, Koide E, Sidi S, Shulman Z, Wang C, Marto JA, Dhe-Paganon S, Look T, Zhou XZ, Lu KP, Sears RC, Chesler L, Gray NS, London N. Dubiella C, et al. Among authors: lu kp. Nat Chem Biol. 2021 Sep;17(9):954-963. doi: 10.1038/s41589-021-00786-7. Epub 2021 May 10. Nat Chem Biol. 2021. PMID: 33972797 Free PMC article.

26

Combined fenestrated/chimney thoracic endovascular repair for the treatment of blunt traumatic aortic injury: A case report.

Zhang L, Wu HP, Li X, Lü KP, Song HH, Zeng CL, Liu JL. Zhang L, et al. Among authors: lu kp. Chin J Traumatol. 2021 May;24(3):140-143. doi: 10.1016/j.cjtee.2021.02.003. Epub 2021 Feb 9. Chin J Traumatol. 2021. PMID: 33678538 Free PMC article.

27

The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.

Hou X, Yang F, Li A, Zhao D, Ma N, Chen L, Lin S, Lin Y, Wang L, Yan X, Zheng M, Lee TH, Zhou XZ, Lu KP, Liu H. Hou X, et al. Among authors: lu kp. Cereb Cortex. 2021 May 10;31(6):3082-3095. doi: 10.1093/cercor/bhab004. Cereb Cortex. 2021. PMID: 33569579 Free PMC article.

28

[Sudden sensorineural hearing loss with acanthosis nigricans and guillain-barre syndrome: a case report].

Lu KP, Xiong WP, Fan ZM, Wang MM. Lu KP, et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Nov 7;55(11):1072-1074. doi: 10.3760/cma.j.cn115330-20191206-00747. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020. PMID: 33210890 Chinese.

29

Identification, expression, and artificial selection of silkworm epigenetic modification enzymes.

Gao R, Li CL, Tong XL, Han MJ, Lu KP, Liang SB, Hu H, Luan Y, Zhang BL, Liu YY, Dai FY. Gao R, et al. Among authors: lu kp. BMC Genomics. 2020 Oct 23;21(1):740. doi: 10.1186/s12864-020-07155-z. BMC Genomics. 2020. PMID: 33096977 Free PMC article.

30

The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship.

Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC. Ospina-Romero M, et al. Among authors: lu kp. Alzheimer Dis Assoc Disord. 2021 Jul-Sep 01;35(3):271-274. doi: 10.1097/WAD.0000000000000398. Alzheimer Dis Assoc Disord. 2021. PMID: 32568784 Free PMC article.

31

Identification of a potent and selective covalent Pin1 inhibitor.

Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Pinch BJ, et al. Among authors: lu kp. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483379 Free PMC article.

32

Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.

Chen D, Mei Y, Kim N, Lan G, Gan CL, Fan F, Zhang T, Xia Y, Wang L, Lin C, Ke F, Zhou XZ, Lu KP, Lee TH. Chen D, et al. Among authors: lu kp. J Pineal Res. 2020 Sep;69(2):e12665. doi: 10.1111/jpi.12665. Epub 2020 May 27. J Pineal Res. 2020. PMID: 32358852 Free PMC article.

33

Cluster validity indices for mixture hazards regression models.

Chang YW, Lu KP, Chang ST. Chang YW, et al. Among authors: lu kp. Math Biosci Eng. 2019 Dec 10;17(2):1616-1636. doi: 10.3934/mbe.2020085. Math Biosci Eng. 2019. PMID: 32233599 Free article.

34

Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition.

Luo ML, Zheng F, Chen W, Liang ZM, Chandramouly G, Tan J, Willis NA, Chen CH, Taveira MO, Zhou XZ, Lu KP, Scully R, Wulf GM, Hu H. Luo ML, et al. Among authors: lu kp. Cancer Res. 2020 Jul 15;80(14):3033-3045. doi: 10.1158/0008-5472.CAN-19-2739. Epub 2020 Mar 19. Cancer Res. 2020. PMID: 32193285 Free PMC article.

35

PIN1 Inhibition Sensitizes Chemotherapy in Gastric Cancer Cells by Targeting Stem Cell-like Traits and Multiple Biomarkers.

Zhang ZZ, Yu WX, Zheng M, Liao XH, Wang JC, Yang DY, Lu WX, Wang L, Zhang S, Liu HK, Zhou XZ, Lu KP. Zhang ZZ, et al. Among authors: lu kp. Mol Cancer Ther. 2020 Mar;19(3):906-919. doi: 10.1158/1535-7163.MCT-19-0656. Epub 2019 Dec 26. Mol Cancer Ther. 2020. PMID: 31879364

36

Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms.

Huang S, Chen Y, Liang ZM, Li NN, Liu Y, Zhu Y, Liao D, Zhou XZ, Lu KP, Yao Y, Luo ML. Huang S, et al. Among authors: lu kp. Front Cell Dev Biol. 2019 Dec 6;7:322. doi: 10.3389/fcell.2019.00322. eCollection 2019. Front Cell Dev Biol. 2019. PMID: 31867329 Free PMC article.

37

Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways.

Albayram O, MacIver B, Mathai J, Verstegen A, Baxley S, Qiu C, Bell C, Caldarone BJ, Zhou XZ, Lu KP, Zeidel M. Albayram O, et al. Among authors: lu kp. Sci Rep. 2019 Jun 14;9(1):8646. doi: 10.1038/s41598-019-45234-8. Sci Rep. 2019. PMID: 31201348 Free PMC article.

38

Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis.

Chen L, Xu X, Wen X, Xu S, Wang L, Lu W, Jiang M, Huang J, Yang D, Wang J, Zheng M, Zhou XZ, Lu KP, Liu H. Chen L, et al. Among authors: lu kp. Cancer Sci. 2019 Aug;110(8):2442-2455. doi: 10.1111/cas.14085. Epub 2019 Jun 25. Cancer Sci. 2019. PMID: 31148345 Free PMC article.

39

Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K/AKT and Wnt/β-catenin oncogenic pathways.

Zhang Z, Yu W, Zheng M, Liao X, Wang J, Yang D, Lu W, Wang L, Zhang S, Liu H, Zhou XZ, Lu KP. Zhang Z, et al. Among authors: lu kp. Mol Carcinog. 2019 Aug;58(8):1450-1464. doi: 10.1002/mc.23027. Epub 2019 Apr 26. Mol Carcinog. 2019. PMID: 31026381 Free PMC article.

40

An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy.

Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. Liu PH, et al. Among authors: lu kp. Nat Cell Biol. 2019 Feb;21(2):203-213. doi: 10.1038/s41556-018-0260-7. Epub 2019 Jan 21. Nat Cell Biol. 2019. PMID: 30664786 Free PMC article.

41

Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite.

Liao WS, Ho Y, Lin YW, Naveen Raj E, Liu KK, Chen C, Zhou XZ, Lu KP, Chao JI. Liao WS, et al. Among authors: lu kp. Acta Biomater. 2019 Mar 1;86:395-405. doi: 10.1016/j.actbio.2019.01.025. Epub 2019 Jan 16. Acta Biomater. 2019. PMID: 30660004

42

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.

Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, Lu KP, Huang J, Zhao C, Sun Y, Gao X, Pandolfi PP, Wei W. Zhang J, et al. Among authors: lu kp. Dev Cell. 2019 Feb 11;48(3):329-344.e5. doi: 10.1016/j.devcel.2018.11.035. Epub 2018 Dec 27. Dev Cell. 2019. PMID: 30595538 Free PMC article.

43

Pin1 inhibition reverses the acquired resistance of human hepatocellular carcinoma cells to Regorafenib via the Gli1/Snail/E-cadherin pathway.

Wang J, Zhang N, Han Q, Lu W, Wang L, Yang D, Zheng M, Zhang Z, Liu H, Lee TH, Zhou XZ, Lu KP. Wang J, et al. Among authors: lu kp. Cancer Lett. 2019 Mar 1;444:82-93. doi: 10.1016/j.canlet.2018.12.010. Epub 2018 Dec 21. Cancer Lett. 2019. PMID: 30583078 Free PMC article.

44

Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases.

Albayram O, Angeli P, Bernstein E, Baxley S, Gao Z, Lu KP, Zhou XZ. Albayram O, et al. Among authors: lu kp. J Alzheimers Dis Parkinsonism. 2018;8(3):443. doi: 10.4172/2161-0460.1000443. Epub 2018 Jun 29. J Alzheimers Dis Parkinsonism. 2018. PMID: 30197831 Free PMC article.

45

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.

Kozono S, Lin YM, Seo HS, Pinch B, Lian X, Qiu C, Herbert MK, Chen CH, Tan L, Gao ZJ, Massefski W, Doctor ZM, Jackson BP, Chen Y, Dhe-Paganon S, Lu KP, Zhou XZ. Kozono S, et al. Among authors: lu kp. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2. Nat Commun. 2018. PMID: 30093655 Free PMC article.

46

Correction to: Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.

Lian X, Lin YM, Kozono S, Herbert MK, Li X, Yuan X, Guo J, Guo Y, Tang M, Lin J, Huang Y, Wang B, Qiu C, Tsai CY, Xie J, Gao ZJ, Wu Y, Liu H, Zhou XZ, Lu KP, Chen Y. Lian X, et al. Among authors: lu kp. J Hematol Oncol. 2018 Jul 11;11(1):94. doi: 10.1186/s13045-018-0634-0. J Hematol Oncol. 2018. PMID: 29996897 Free PMC article.

47

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.

Lian X, Lin YM, Kozono S, Herbert MK, Li X, Yuan X, Guo J, Guo Y, Tang M, Lin J, Huang Y, Wang B, Qiu C, Tsai CY, Xie J, Gao ZJ, Wu Y, Liu H, Zhou XZ, Lu KP, Chen Y. Lian X, et al. Among authors: lu kp. J Hematol Oncol. 2018 May 30;11(1):73. doi: 10.1186/s13045-018-0611-7. J Hematol Oncol. 2018. PMID: 29848341 Free PMC article.

48

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP. Nechama M, et al. Among authors: lu kp. Nat Commun. 2018 Apr 23;9(1):1603. doi: 10.1038/s41467-018-03886-6. Nat Commun. 2018. PMID: 29686383 Free PMC article. Clinical Trial.

49

Association of CYP3A4*1B genotype with Cyclosporin A pharmacokinetics in renal transplant recipients: A meta-analysis.

Wang CE, Lu KP, Chang Z, Guo ML, Qiao HL. Wang CE, et al. Among authors: lu kp. Gene. 2018 Jul 20;664:44-49. doi: 10.1016/j.gene.2018.04.043. Epub 2018 Apr 18. Gene. 2018. PMID: 29678659

50

Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Tagge CA, et al. Among authors: lu kp. Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350. Brain. 2018. PMID: 29360998 Free PMC article.

51

A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways.

Yang D, Luo W, Wang J, Zheng M, Liao XH, Zhang N, Lu W, Wang L, Chen AZ, Wu WG, Liu H, Wang SB, Zhou XZ, Lu KP. Yang D, et al. Among authors: lu kp. J Control Release. 2018 Jan 10;269:405-422. doi: 10.1016/j.jconrel.2017.11.031. Epub 2017 Nov 21. J Control Release. 2018. PMID: 29170140 Free PMC article.

52

Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae.

Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, Yan S, Gormley W, Puccio AM, Okonkwo DO, Lucke-Wold B, Bailes J, Meehan W, Zeidel M, Lu KP, Zhou XZ. Albayram O, et al. Among authors: lu kp. Nat Commun. 2017 Oct 17;8(1):1000. doi: 10.1038/s41467-017-01068-4. Nat Commun. 2017. PMID: 29042562 Free PMC article.

53

Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting.

Agoston D, Arun P, Bellgowan P, Broglio S, Cantu R, Cook D, da Silva UO, Dickstein D, Elder G, Fudge E, Gandy S, Gill J, Glenn JF, Gupta RK, Hinds S, Hoffman S, Lattimore T, Lin A, Lu KP, Maroon J, Okonkwo D, Perl D, Robinson M, Rosen C, Smith D. Agoston D, et al. Among authors: lu kp. J Neurotrauma. 2017 Sep;34(S1):S6-S17. doi: 10.1089/neu.2017.5220. J Neurotrauma. 2017. PMID: 28937955 Free PMC article.

54

Association of cancer and Alzheimer's disease risk in a national cohort of veterans.

Frain L, Swanson D, Cho K, Gagnon D, Lu KP, Betensky RA, Driver J. Frain L, et al. Among authors: lu kp. Alzheimers Dement. 2017 Dec;13(12):1364-1370. doi: 10.1016/j.jalz.2017.04.012. Epub 2017 Jul 12. Alzheimers Dement. 2017. PMID: 28711346 Free PMC article.

55

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4.

Hu X, Dong SH, Chen J, Zhou XZ, Chen R, Nair S, Lu KP, Chen LF. Hu X, et al. Among authors: lu kp. Oncogene. 2017 Sep 7;36(36):5177-5188. doi: 10.1038/onc.2017.137. Epub 2017 May 8. Oncogene. 2017. PMID: 28481868 Free PMC article.

56

Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.

Zheng M, Xu H, Liao XH, Chen CP, Zhang AL, Lu W, Wang L, Yang D, Wang J, Liu H, Zhou XZ, Lu KP. Zheng M, et al. Among authors: lu kp. Oncotarget. 2017 May 2;8(18):29771-29784. doi: 10.18632/oncotarget.15967. Oncotarget. 2017. PMID: 28404959 Free PMC article.

57

MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways.

Yan X, Zhu Z, Xu S, Yang LN, Liao XH, Zheng M, Yang D, Wang J, Chen D, Wang L, Liu X, Liu J, Chen RH, Zhou XZ, Lu KP, Liu H. Yan X, et al. Among authors: lu kp. Sci Rep. 2017 Apr 6;7:45915. doi: 10.1038/srep45915. Sci Rep. 2017. PMID: 28383568 Free PMC article.

58

Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways.

Liao XH, Zhang AL, Zheng M, Li MQ, Chen CP, Xu H, Chu QS, Yang D, Lu W, Tsai TF, Liu H, Zhou XZ, Lu KP. Liao XH, et al. Among authors: lu kp. Sci Rep. 2017 Mar 6;7:43639. doi: 10.1038/srep43639. Sci Rep. 2017. PMID: 28262728 Free PMC article.

59

Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration.

Albayram O, Herbert MK, Kondo A, Tsai CY, Baxley S, Lian X, Hansen M, Zhou XZ, Lu KP. Albayram O, et al. Among authors: lu kp. Cell Biosci. 2016 Dec 5;6:59. doi: 10.1186/s13578-016-0124-4. eCollection 2016. Cell Biosci. 2016. PMID: 27980715 Free PMC article. Review.

60

Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer's Disease.

Kondo A, Albayram O, Zhou XZ, Lu KP. Kondo A, et al. Among authors: lu kp. Methods Mol Biol. 2017;1523:415-425. doi: 10.1007/978-1-4939-6598-4_28. Methods Mol Biol. 2017. PMID: 27975268

61

The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections.

Wang J, Liao XH, Zheng M, Yang D, Zhou XZ, Liu H, Lu KP. Wang J, et al. Among authors: lu kp. Curr Mol Med. 2016;16(9):793-802. doi: 10.2174/1566524016666161124103654. Curr Mol Med. 2016. PMID: 27889995 Review.

62

Neighboring phosphoSer-Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding.

Rogals MJ, Greenwood AI, Kwon J, Lu KP, Nicholson LK. Rogals MJ, et al. Among authors: lu kp. FEBS J. 2016 Dec;283(24):4528-4548. doi: 10.1111/febs.13943. Epub 2016 Nov 20. FEBS J. 2016. PMID: 27790836 Free PMC article.

63

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.

Nogués L, Reglero C, Rivas V, Salcedo A, Lafarga V, Neves M, Ramos P, Mendiola M, Berjón A, Stamatakis K, Zhou XZ, Lu KP, Hardisson D, Mayor F Jr, Penela P. Nogués L, et al. Among authors: lu kp. EBioMedicine. 2016 Nov;13:132-145. doi: 10.1016/j.ebiom.2016.09.030. Epub 2016 Oct 1. EBioMedicine. 2016. PMID: 27720394 Free PMC article.

64

Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway.

Fisher CL, Resnick RJ, De S, Acevedo LA, Lu KP, Schroeder FC, Nicholson LK. Fisher CL, et al. Among authors: lu kp. J Alzheimers Dis. 2017;55(1):391-410. doi: 10.3233/JAD-160051. J Alzheimers Dis. 2017. PMID: 27662285 Free PMC article.

65

Potential of the Antibody Against cis-Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury.

Lu KP, Kondo A, Albayram O, Herbert MK, Liu H, Zhou XZ. Lu KP, et al. JAMA Neurol. 2016 Nov 1;73(11):1356-1362. doi: 10.1001/jamaneurol.2016.2027. JAMA Neurol. 2016. PMID: 27654282 Review.

66

The role of Pin1 in the development and treatment of cancer.

Min SH, Zhou XZ, Lu KP. Min SH, et al. Among authors: lu kp. Arch Pharm Res. 2016 Dec;39(12):1609-1620. doi: 10.1007/s12272-016-0821-x. Epub 2016 Aug 29. Arch Pharm Res. 2016. PMID: 27572155 Review.

67

Critical role of XBP1 in cancer signalling is regulated by PIN1.

Chae U, Park SJ, Kim B, Wei S, Min JS, Lee JH, Park SH, Lee AH, Lu KP, Lee DS, Min SH. Chae U, et al. Among authors: lu kp. Biochem J. 2016 Sep 1;473(17):2603-10. doi: 10.1042/BCJ20160482. Epub 2016 Jun 22. Biochem J. 2016. PMID: 27334111

68

The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.

Zhou XZ, Lu KP. Zhou XZ, et al. Among authors: lu kp. Nat Rev Cancer. 2016 Jul;16(7):463-78. doi: 10.1038/nrc.2016.49. Epub 2016 Jun 3. Nat Rev Cancer. 2016. PMID: 27256007 Review.

69

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.

Hilton BA, Li Z, Musich PR, Wang H, Cartwright BM, Serrano M, Zhou XZ, Lu KP, Zou Y. Hilton BA, et al. Among authors: lu kp. Mol Cell. 2016 Feb 4;61(3):487. doi: 10.1016/j.molcel.2016.01.016. Epub 2016 Feb 4. Mol Cell. 2016. PMID: 28837803 Free article. No abstract available.

70

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.

Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP. Balastik M, et al. Among authors: lu kp. Cell Rep. 2015 Oct 27;13(4):812-828. doi: 10.1016/j.celrep.2015.09.026. Epub 2015 Oct 17. Cell Rep. 2015. PMID: 26489457 Free PMC article.

71

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.

Hilton BA, Li Z, Musich PR, Wang H, Cartwright BM, Serrano M, Zhou XZ, Lu KP, Zou Y. Hilton BA, et al. Among authors: lu kp. Mol Cell. 2015 Oct 1;60(1):35-46. doi: 10.1016/j.molcel.2015.08.008. Epub 2015 Sep 18. Mol Cell. 2015. PMID: 26387736 Free PMC article.

72

[Effect of Long-term Fertilizer Application on the Stability of Organic Carbon in Particle Size Fractions of a Paddy Soil in Zhejiang Province, China].

Mao XL, Lu KP, Sun T, Zhang XK, He LZ, Wang HL. Mao XL, et al. Among authors: lu kp. Huan Jing Ke Xue. 2015 May;36(5):1827-35. Huan Jing Ke Xue. 2015. PMID: 26314136 Chinese.

73

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.

Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein LE, Pascual-Leone A, McKee AC, Meehan W, Zhou XZ, Lu KP. Kondo A, et al. Among authors: lu kp. Nature. 2015 Jul 23;523(7561):431-436. doi: 10.1038/nature14658. Epub 2015 Jul 15. Nature. 2015. PMID: 26176913 Free PMC article.

74

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. Wei S, et al. Among authors: lu kp. Nat Med. 2015 May;21(5):457-66. doi: 10.1038/nm.3839. Epub 2015 Apr 13. Nat Med. 2015. PMID: 25849135 Free PMC article.

75

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Luo ML, et al. Among authors: lu kp. Cell Rep. 2015 Apr 7;11(1):111-24. doi: 10.1016/j.celrep.2015.03.002. Epub 2015 Mar 26. Cell Rep. 2015. PMID: 25818297 Free PMC article.

76

Lead accumulation and tolerance of Moso bamboo (Phyllostachys pubescens) seedlings: applications of phytoremediation.

Liu D, Li S, Islam E, Chen JR, Wu JS, Ye ZQ, Peng DL, Yan WB, Lu KP. Liu D, et al. Among authors: lu kp. J Zhejiang Univ Sci B. 2015 Feb;16(2):123-30. doi: 10.1631/jzus.B1400107. J Zhejiang Univ Sci B. 2015. PMID: 25644467 Free PMC article.

77

Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation.

Marsolier J, Perichon M, DeBarry JD, Villoutreix BO, Chluba J, Lopez T, Garrido C, Zhou XZ, Lu KP, Fritsch L, Ait-Si-Ali S, Mhadhbi M, Medjkane S, Weitzman JB. Marsolier J, et al. Among authors: lu kp. Nature. 2015 Apr 16;520(7547):378-82. doi: 10.1038/nature14044. Epub 2015 Jan 26. Nature. 2015. PMID: 25624101 Free PMC article.

78

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease.

Driver JA, Zhou XZ, Lu KP. Driver JA, et al. Among authors: lu kp. Biochim Biophys Acta. 2015 Oct;1850(10):2069-76. doi: 10.1016/j.bbagen.2014.12.025. Epub 2015 Jan 10. Biochim Biophys Acta. 2015. PMID: 25583562 Free PMC article. Review.

79

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.

Chen CH, Li W, Sultana R, You MH, Kondo A, Shahpasand K, Kim BM, Luo ML, Nechama M, Lin YM, Yao Y, Lee TH, Zhou XZ, Swomley AM, Butterfield DA, Zhang Y, Lu KP. Chen CH, et al. Among authors: lu kp. Neurobiol Dis. 2015 Apr;76:13-23. doi: 10.1016/j.nbd.2014.12.027. Epub 2015 Jan 6. Neurobiol Dis. 2015. PMID: 25576397 Free PMC article.

80

Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women.

Lin H, Yin Z, Yu XY, Lin N, Lin Y, Chen J, Chen YZ, Lu KP, Liu HK. Lin H, et al. Among authors: lu kp. Genet Mol Res. 2014 Aug 7;13(3):6126-34. doi: 10.4238/2014.August.7.28. Genet Mol Res. 2014. PMID: 25117371 Free article.

81

Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer.

Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Luo ML, et al. Among authors: lu kp. Cancer Res. 2014 Jul 1;74(13):3603-16. doi: 10.1158/0008-5472.CAN-13-2785. Epub 2014 May 1. Cancer Res. 2014. PMID: 24786790 Free PMC article.

82

The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity.

Jalouli M, Déry MA, Lafleur VN, Lamalice L, Zhou XZ, Lu KP, Richard DE. Jalouli M, et al. Among authors: lu kp. Cell Signal. 2014 Aug;26(8):1649-56. doi: 10.1016/j.cellsig.2014.04.005. Epub 2014 Apr 12. Cell Signal. 2014. PMID: 24726894

83

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Liu P, et al. Among authors: lu kp. Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9. Nature. 2014. PMID: 24670654 Free PMC article.

84

Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease.

Driver JA, Zhou XZ, Lu KP. Driver JA, et al. Among authors: lu kp. Discov Med. 2014 Feb;17(92):93-9. Discov Med. 2014. PMID: 24534472 Free PMC article. Review.

85

SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function.

Chen CH, Chang CC, Lee TH, Luo M, Huang P, Liao PH, Wei S, Li FA, Chen RH, Zhou XZ, Shih HM, Lu KP. Chen CH, et al. Among authors: lu kp. Cancer Res. 2013 Jul 1;73(13):3951-62. doi: 10.1158/0008-5472.CAN-12-4360. Epub 2013 Apr 30. Cancer Res. 2013. PMID: 23633483 Free PMC article.

86

Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.

Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA. Toko H, et al. Among authors: lu kp. Circ Res. 2013 Apr 26;112(9):1244-52. doi: 10.1161/CIRCRESAHA.113.301084. Epub 2013 Mar 13. Circ Res. 2013. PMID: 23487407 Free PMC article.

87

Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress.

Keune WJ, Jones DR, Bultsma Y, Sommer L, Zhou XZ, Lu KP, Divecha N. Keune WJ, et al. Among authors: lu kp. Sci Signal. 2012 Nov 27;5(252):ra86. doi: 10.1126/scisignal.2003223. Sci Signal. 2012. PMID: 23193159

88

Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications.

Nakamura K, Zhou XZ, Lu KP. Nakamura K, et al. Among authors: lu kp. Curr Mol Med. 2013 Aug;13(7):1098-109. doi: 10.2174/1566524011313070001. Curr Mol Med. 2013. PMID: 23157676

89

Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668.

De S, Greenwood AI, Rogals MJ, Kovrigin EL, Lu KP, Nicholson LK. De S, et al. Among authors: lu kp. Biochemistry. 2012 Oct 30;51(43):8583-96. doi: 10.1021/bi3008214. Epub 2012 Oct 16. Biochemistry. 2012. PMID: 23025283 Free PMC article.

90

JNK3 perpetuates metabolic stress induced by Aβ peptides.

Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. Yoon SO, et al. Among authors: lu kp. Neuron. 2012 Sep 6;75(5):824-37. doi: 10.1016/j.neuron.2012.06.024. Neuron. 2012. PMID: 22958823 Free PMC article.

91

Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers.

Luo T, Yu J, Nguyen J, Wang CR, Bristow RG, Jaffray DA, Zhou XZ, Lu KP, Lu QB. Luo T, et al. Among authors: lu kp. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10175-80. doi: 10.1073/pnas.1203451109. Epub 2012 Jun 8. Proc Natl Acad Sci U S A. 2012. PMID: 22685209 Free PMC article.

92

Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.

Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP. Nakamura K, et al. Among authors: lu kp. Mol Cell Biol. 2012 Aug;32(15):2966-78. doi: 10.1128/MCB.05688-11. Epub 2012 May 29. Mol Cell Biol. 2012. PMID: 22645310 Free PMC article.

93

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.

Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP. Min SH, et al. Among authors: lu kp. Mol Cell. 2012 Jun 29;46(6):771-83. doi: 10.1016/j.molcel.2012.04.012. Epub 2012 May 17. Mol Cell. 2012. PMID: 22608923 Free PMC article.

94

Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.

Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A. Rangasamy V, et al. Among authors: lu kp. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8149-54. doi: 10.1073/pnas.1200804109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566623 Free PMC article.

95

Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.

Nakamura K, Greenwood A, Binder L, Bigio EH, Denial S, Nicholson L, Zhou XZ, Lu KP. Nakamura K, et al. Among authors: lu kp. Cell. 2012 Mar 30;149(1):232-44. doi: 10.1016/j.cell.2012.02.016. Cell. 2012. PMID: 22464332 Free PMC article.

96

Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AβPP.

Pastorino L, Ma SL, Balastik M, Huang P, Pandya D, Nicholson L, Lu KP. Pastorino L, et al. Among authors: lu kp. J Alzheimers Dis. 2012;30(2):277-97. doi: 10.3233/JAD-2012-111259. J Alzheimers Dis. 2012. PMID: 22430533

97

Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study.

Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, Kiel DP, Lu KP, Seshadri S, Wolf PA. Driver JA, et al. Among authors: lu kp. BMJ. 2012 Mar 12;344:e1442. doi: 10.1136/bmj.e1442. BMJ. 2012. PMID: 22411920 Free PMC article.

98

FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling.

Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X. Wang J, et al. Among authors: lu kp. Oncogene. 2012 Nov 8;31(45):4798-802. doi: 10.1038/onc.2011.635. Epub 2012 Jan 16. Oncogene. 2012. PMID: 22249250 Free PMC article.

99

Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease.

Ma SL, Pastorino L, Zhou XZ, Lu KP. Ma SL, et al. Among authors: lu kp. J Biol Chem. 2012 Mar 2;287(10):6969-73. doi: 10.1074/jbc.C111.298596. Epub 2011 Dec 19. J Biol Chem. 2012. PMID: 22184106 Free PMC article.

100

Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1.

Rajbhandari P, Finn G, Solodin NM, Singarapu KK, Sahu SC, Markley JL, Kadunc KJ, Ellison-Zelski SJ, Kariagina A, Haslam SZ, Lu KP, Alarid ET. Rajbhandari P, et al. Among authors: lu kp. Mol Cell Biol. 2012 Jan;32(2):445-57. doi: 10.1128/MCB.06073-11. Epub 2011 Nov 7. Mol Cell Biol. 2012. PMID: 22064478 Free PMC article.

101

Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis.

Greenwood AI, Rogals MJ, De S, Lu KP, Kovrigin EL, Nicholson LK. Greenwood AI, et al. Among authors: lu kp. J Biomol NMR. 2011 Sep;51(1-2):21-34. doi: 10.1007/s10858-011-9538-9. Epub 2011 Sep 27. J Biomol NMR. 2011. PMID: 21947912 Free PMC article.

102

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.

Liou YC, Zhou XZ, Lu KP. Liou YC, et al. Among authors: lu kp. Trends Biochem Sci. 2011 Oct;36(10):501-14. doi: 10.1016/j.tibs.2011.07.001. Epub 2011 Aug 17. Trends Biochem Sci. 2011. PMID: 21852138 Free PMC article. Review.

103

A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.

Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH. Yuan WC, et al. Among authors: lu kp. Cancer Cell. 2011 Aug 16;20(2):214-28. doi: 10.1016/j.ccr.2011.07.008. Cancer Cell. 2011. PMID: 21840486 Free article.

104

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.

Tun-Kyi A, Finn G, Greenwood A, Nowak M, Lee TH, Asara JM, Tsokos GC, Fitzgerald K, Israel E, Li X, Exley M, Nicholson LK, Lu KP. Tun-Kyi A, et al. Among authors: lu kp. Nat Immunol. 2011 Jul 10;12(8):733-41. doi: 10.1038/ni.2069. Nat Immunol. 2011. PMID: 21743479 Free PMC article.

105

Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.

Lee TH, Pastorino L, Lu KP. Lee TH, et al. Among authors: lu kp. Expert Rev Mol Med. 2011 Jun 20;13:e21. doi: 10.1017/S1462399411001906. Expert Rev Mol Med. 2011. PMID: 21682951 Review.

106

Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.

Lee TH, Chen CH, Suizu F, Huang P, Schiene-Fischer C, Daum S, Zhang YJ, Goate A, Chen RH, Zhou XZ, Lu KP. Lee TH, et al. Among authors: lu kp. Mol Cell. 2011 Apr 22;42(2):147-59. doi: 10.1016/j.molcel.2011.03.005. Epub 2011 Apr 14. Mol Cell. 2011. PMID: 21497122 Free PMC article.

107

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.

Zhou XZ, Huang P, Shi R, Lee TH, Lu G, Zhang Z, Bronson R, Lu KP. Zhou XZ, et al. Among authors: lu kp. J Clin Invest. 2011 Apr;121(4):1266-82. doi: 10.1172/JCI43452. Epub 2011 Mar 23. J Clin Invest. 2011. PMID: 21436583 Free PMC article.

108

Activation of group IVC phospholipase A(2) by polycyclic aromatic hydrocarbons induces apoptosis of human coronary artery endothelial cells.

Tithof PK, Richards SM, Elgayyar MA, Menn FM, Vulava VM, McKay L, Sanseverino J, Sayler G, Tucker DE, Leslie CC, Lu KP, Ramos KS. Tithof PK, et al. Among authors: lu kp. Arch Toxicol. 2011 Jun;85(6):623-34. doi: 10.1007/s00204-010-0614-9. Epub 2010 Dec 4. Arch Toxicol. 2011. PMID: 21132278 Free PMC article.

109

Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.

Soohoo CY, Shi R, Lee TH, Huang P, Lu KP, Zhou XZ. Soohoo CY, et al. Among authors: lu kp. J Biol Chem. 2011 Feb 4;286(5):3894-906. doi: 10.1074/jbc.M110.180174. Epub 2010 Nov 30. J Biol Chem. 2011. PMID: 21119197 Free PMC article.

110

Risk factors of urinary frequency among women aged 60 and older in Taiwan.

Hsieh CH, Chang WC, Hsu MI, Chiang HS, Chang ST, Lee MC, Lee MS, Lu KP, Su TH, Lee SH, Chen FM. Hsieh CH, et al. Among authors: lu kp. Taiwan J Obstet Gynecol. 2010 Sep;49(3):260-5. doi: 10.1016/S1028-4559(10)60058-7. Taiwan J Obstet Gynecol. 2010. PMID: 21056308 Free article.

111

Pin1: a new genetic link between Alzheimer's disease, cancer and aging.

Driver JA, Lu KP. Driver JA, et al. Among authors: lu kp. Curr Aging Sci. 2010 Dec;3(3):158-65. doi: 10.2174/1874609811003030158. Curr Aging Sci. 2010. PMID: 20735350 Review.

112

A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.

Ma SL, Tang NL, Tam CW, Lui VW, Lam LC, Chiu HF, Driver JA, Pastorino L, Lu KP. Ma SL, et al. Among authors: lu kp. Neurobiol Aging. 2012 Apr;33(4):804-13. doi: 10.1016/j.neurobiolaging.2010.05.018. Epub 2010 Jun 30. Neurobiol Aging. 2012. PMID: 20580132 Free PMC article.

113

Prevalence of urinary frequency among women aged 60 years and older in Taiwan.

Hsieh CH, Chang WC, Hsu MI, Lee MC, Lee MS, Chiang HS, Chang ST, Su TH, Lu KP, Lee SH, Chen FM. Hsieh CH, et al. Among authors: lu kp. Taiwan J Obstet Gynecol. 2009 Dec;48(4):385-8. doi: 10.1016/S1028-4559(09)60328-4. Taiwan J Obstet Gynecol. 2009. PMID: 20045760 Free article.

114

Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family.

Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhou XZ, Lu KP, Gélinas C. Fan G, et al. Among authors: lu kp. Cancer Res. 2009 Jun 1;69(11):4589-97. doi: 10.1158/0008-5472.CAN-08-4117. Epub 2009 May 19. Cancer Res. 2009. PMID: 19458071 Free PMC article.

115

Pinning down HER2-ER crosstalk in SMRT regulation.

Ryo A, Wulf G, Lee TH, Lu KP. Ryo A, et al. Among authors: lu kp. Trends Biochem Sci. 2009 Apr;34(4):162-5. doi: 10.1016/j.tibs.2008.12.004. Epub 2009 Mar 9. Trends Biochem Sci. 2009. PMID: 19269830

116

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability.

Lam PB, Burga LN, Wu BP, Hofstatter EW, Lu KP, Wulf GM. Lam PB, et al. Among authors: lu kp. Mol Cancer. 2008 Dec 15;7:91. doi: 10.1186/1476-4598-7-91. Mol Cancer. 2008. PMID: 19077306 Free PMC article.

117

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance.

Lee TH, Tun-Kyi A, Shi R, Lim J, Soohoo C, Finn G, Balastik M, Pastorino L, Wulf G, Zhou XZ, Lu KP. Lee TH, et al. Among authors: lu kp. Nat Cell Biol. 2009 Jan;11(1):97-105. doi: 10.1038/ncb1818. Epub 2008 Dec 7. Nat Cell Biol. 2009. PMID: 19060891 Free PMC article.

118

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.

Balastik M, Ferraguti F, Pires-da Silva A, Lee TH, Alvarez-Bolado G, Lu KP, Gruss P. Balastik M, et al. Among authors: lu kp. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12016-21. doi: 10.1073/pnas.0802261105. Epub 2008 Aug 7. Proc Natl Acad Sci U S A. 2008. PMID: 18687884 Free PMC article.

119

Phosphorylation-specific prolyl isomerase Pin1 as a new diagnostic and therapeutic target for cancer.

Finn G, Lu KP. Finn G, et al. Among authors: lu kp. Curr Cancer Drug Targets. 2008 May;8(3):223-9. doi: 10.2174/156800908784293622. Curr Cancer Drug Targets. 2008. PMID: 18473735 Review.

120

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

Cole AR, Soutar MP, Rembutsu M, van Aalten L, Hastie CJ, McLauchlan H, Peggie M, Balastik M, Lu KP, Sutherland C. Cole AR, et al. Among authors: lu kp. J Biol Chem. 2008 Jun 27;283(26):18227-37. doi: 10.1074/jbc.M801645200. Epub 2008 May 6. J Biol Chem. 2008. PMID: 18460467 Free PMC article.

121

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.

Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP. Lim J, et al. Among authors: lu kp. J Clin Invest. 2008 May;118(5):1877-89. doi: 10.1172/JCI34308. J Clin Invest. 2008. PMID: 18431510 Free PMC article.

122

An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors.

Wildemann D, Hernandez Alvarez B, Stoller G, Zhou XZ, Lu KP, Erdmann F, Ferrari D, Fischer G. Wildemann D, et al. Among authors: lu kp. Biol Chem. 2007 Oct;388(10):1103-11. doi: 10.1515/BC.2007.127. Biol Chem. 2007. PMID: 17937625

123

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease.

Lu KP, Zhou XZ. Lu KP, et al. Nat Rev Mol Cell Biol. 2007 Nov;8(11):904-16. doi: 10.1038/nrm2261. Nat Rev Mol Cell Biol. 2007. PMID: 17878917 Review.

124

Prolyl cis-trans isomerization as a molecular timer.

Lu KP, Finn G, Lee TH, Nicholson LK. Lu KP, et al. Nat Chem Biol. 2007 Oct;3(10):619-29. doi: 10.1038/nchembio.2007.35. Nat Chem Biol. 2007. PMID: 17876319 Review.

125

Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury.

Li QM, Tep C, Yune TY, Zhou XZ, Uchida T, Lu KP, Yoon SO. Li QM, et al. Among authors: lu kp. J Neurosci. 2007 Aug 1;27(31):8395-404. doi: 10.1523/JNEUROSCI.2478-07.2007. J Neurosci. 2007. PMID: 17670986 Free PMC article.

126

Structural basis for high-affinity peptide inhibition of human Pin1.

Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lücke C, Hunter T, Lu KP, Fischer G, Noel JP. Zhang Y, et al. Among authors: lu kp. ACS Chem Biol. 2007 May 22;2(5):320-8. doi: 10.1021/cb7000044. ACS Chem Biol. 2007. PMID: 17518432 Free PMC article.

127

Hepatitis B virus x protein and pin1 in liver cancer: "les liaisons dangereuses".

Avila MA, Lu KP. Avila MA, et al. Among authors: lu kp. Gastroenterology. 2007 Mar;132(3):1180-3. doi: 10.1053/j.gastro.2007.01.061. Gastroenterology. 2007. PMID: 17383439 No abstract available.

128

Prolyl cis-trans Isomerization as a molecular timer in Crk signaling.

Nicholson LK, Lu KP. Nicholson LK, et al. Among authors: lu kp. Mol Cell. 2007 Feb 23;25(4):483-5. doi: 10.1016/j.molcel.2007.02.005. Mol Cell. 2007. PMID: 17317620 Free article.

129

Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?

Balastik M, Lim J, Pastorino L, Lu KP. Balastik M, et al. Among authors: lu kp. Biochim Biophys Acta. 2007 Apr;1772(4):422-9. doi: 10.1016/j.bbadis.2007.01.006. Epub 2007 Jan 23. Biochim Biophys Acta. 2007. PMID: 17317113 Free PMC article. Review.

130

Pathogenic mechanisms in Alzheimer's disease.

Pastorino L, Lu KP. Pastorino L, et al. Among authors: lu kp. Eur J Pharmacol. 2006 Sep 1;545(1):29-38. doi: 10.1016/j.ejphar.2006.06.078. Epub 2006 Jul 4. Eur J Pharmacol. 2006. PMID: 16904664 Review.

131

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S. Saitoh T, et al. Among authors: lu kp. Nat Immunol. 2006 Jun;7(6):598-605. doi: 10.1038/ni1347. Epub 2006 May 14. Nat Immunol. 2006. PMID: 16699525

132

Targeting carcinogenesis: a role for the prolyl isomerase Pin1?

Lu KP, Suizu F, Zhou XZ, Finn G, Lam P, Wulf G. Lu KP, et al. Mol Carcinog. 2006 Jun;45(6):397-402. doi: 10.1002/mc.20216. Mol Carcinog. 2006. PMID: 16652378 Review.

133

Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.

Yu L, Mohamed AJ, Vargas L, Berglöf A, Finn G, Lu KP, Smith CI. Yu L, et al. Among authors: lu kp. J Biol Chem. 2006 Jun 30;281(26):18201-7. doi: 10.1074/jbc.M603090200. Epub 2006 Apr 27. J Biol Chem. 2006. PMID: 16644721 Free article.

134

Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries.

Wildemann D, Erdmann F, Alvarez BH, Stoller G, Zhou XZ, Fanghänel J, Schutkowski M, Lu KP, Fischer G. Wildemann D, et al. Among authors: lu kp. J Med Chem. 2006 Apr 6;49(7):2147-50. doi: 10.1021/jm060036n. J Med Chem. 2006. PMID: 16570909

135

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.

Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. Pastorino L, et al. Among authors: lu kp. Nature. 2006 Mar 23;440(7083):528-34. doi: 10.1038/nature04543. Nature. 2006. PMID: 16554819

136

Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis.

Suizu F, Ryo A, Wulf G, Lim J, Lu KP. Suizu F, et al. Among authors: lu kp. Mol Cell Biol. 2006 Feb;26(4):1463-79. doi: 10.1128/MCB.26.4.1463-1479.2006. Mol Cell Biol. 2006. PMID: 16449657 Free PMC article.

137

Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.

Chen SY, Wulf G, Zhou XZ, Rubin MA, Lu KP, Balk SP. Chen SY, et al. Among authors: lu kp. Mol Cell Biol. 2006 Feb;26(3):929-39. doi: 10.1128/MCB.26.3.929-939.2006. Mol Cell Biol. 2006. PMID: 16428447 Free PMC article.

138

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance.

Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ. Lee TH, et al. Among authors: lu kp. J Biol Chem. 2006 Jan 13;281(2):759-68. doi: 10.1074/jbc.M509855200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16275645 Free article.

139

Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer.

Ryo A, Uemura H, Ishiguro H, Saitoh T, Yamaguchi A, Perrem K, Kubota Y, Lu KP, Aoki I. Ryo A, et al. Among authors: lu kp. Clin Cancer Res. 2005 Oct 15;11(20):7523-31. doi: 10.1158/1078-0432.CCR-05-0457. Clin Cancer Res. 2005. PMID: 16243827

140

Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis.

Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA. Sultana R, et al. Among authors: lu kp. Neurobiol Aging. 2006 Jul;27(7):918-25. doi: 10.1016/j.neurobiolaging.2005.05.005. Epub 2005 Jun 13. Neurobiol Aging. 2006. PMID: 15950321

141

Novel genomic targets in oxidant-induced vascular injury.

Partridge CR, Williams ES, Barhoumi R, Tadesse MG, Johnson CD, Lu KP, Meininger GA, Wilson E, Ramos KS. Partridge CR, et al. Among authors: lu kp. J Mol Cell Cardiol. 2005 Jun;38(6):983-96. doi: 10.1016/j.yjmcc.2005.03.006. Epub 2005 Apr 19. J Mol Cell Cardiol. 2005. PMID: 15910882

142

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

Wulf G, Finn G, Suizu F, Lu KP. Wulf G, et al. Among authors: lu kp. Nat Cell Biol. 2005 May;7(5):435-41. doi: 10.1038/ncb0505-435. Nat Cell Biol. 2005. PMID: 15867923 Review.

143

Regulation of Raf-1 by direct feedback phosphorylation.

Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. Dougherty MK, et al. Among authors: lu kp. Mol Cell. 2005 Jan 21;17(2):215-24. doi: 10.1016/j.molcel.2004.11.055. Mol Cell. 2005. PMID: 15664191 Free article.

144

Pinning down phosphorylated tau and tauopathies.

Lim J, Lu KP. Lim J, et al. Among authors: lu kp. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):311-22. doi: 10.1016/j.bbadis.2004.10.003. Epub 2004 Nov 30. Biochim Biophys Acta. 2005. PMID: 15615648 Free article. Review.

145

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.

Wulf G, Garg P, Liou YC, Iglehart D, Lu KP. Wulf G, et al. Among authors: lu kp. EMBO J. 2004 Aug 18;23(16):3397-407. doi: 10.1038/sj.emboj.7600323. Epub 2004 Jul 15. EMBO J. 2004. PMID: 15257284 Free PMC article.

146

Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint.

Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW. Kim KT, et al. Among authors: lu kp. J Biol Chem. 2004 Sep 10;279(37):38597-602. doi: 10.1074/jbc.M400781200. Epub 2004 Jul 9. J Biol Chem. 2004. PMID: 15247272 Free article.

147

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.

Bao L, Kimzey A, Sauter G, Sowadski JM, Lu KP, Wang DG. Bao L, et al. Among authors: lu kp. Am J Pathol. 2004 May;164(5):1727-37. doi: 10.1016/S0002-9440(10)63731-5. Am J Pathol. 2004. PMID: 15111319 Free PMC article.

148

Pinning down cell signaling, cancer and Alzheimer's disease.

Lu KP. Lu KP. Trends Biochem Sci. 2004 Apr;29(4):200-9. doi: 10.1016/j.tibs.2004.02.002. Trends Biochem Sci. 2004. PMID: 15082314 Review.

149

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Ryo A, et al. Among authors: lu kp. Mol Cell. 2003 Dec;12(6):1413-26. doi: 10.1016/s1097-2765(03)00490-8. Mol Cell. 2003. PMID: 14690596 Free article.

150

Pin1 modulates the structure and function of human RNA polymerase II.

Xu YX, Hirose Y, Zhou XZ, Lu KP, Manley JL. Xu YX, et al. Among authors: lu kp. Genes Dev. 2003 Nov 15;17(22):2765-76. doi: 10.1101/gad.1135503. Epub 2003 Nov 4. Genes Dev. 2003. PMID: 14600023 Free PMC article.

151

The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer.

Ayala G, Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L. Ayala G, et al. Among authors: lu kp. Cancer Res. 2003 Oct 1;63(19):6244-51. Cancer Res. 2003. PMID: 14559810

152

Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics.

Lu KP. Lu KP. Cancer Cell. 2003 Sep;4(3):175-80. doi: 10.1016/s1535-6108(03)00218-6. Cancer Cell. 2003. PMID: 14522251 Free article. Review. No abstract available.

153

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Liou YC, et al. Among authors: lu kp. Nature. 2003 Jul 31;424(6948):556-61. doi: 10.1038/nature01832. Nature. 2003. PMID: 12891359

154

Redox regulation of a novel L1Md-A2 retrotransposon in vascular smooth muscle cells.

Lu KP, Ramos KS. Lu KP, et al. J Biol Chem. 2003 Jul 25;278(30):28201-9. doi: 10.1074/jbc.M303888200. Epub 2003 Apr 24. J Biol Chem. 2003. PMID: 12714586 Free article.

155

Role of Pin2/TRF1 in telomere maintenance and cell cycle control.

Zhou XZ, Perrem K, Lu KP. Zhou XZ, et al. Among authors: lu kp. J Cell Biochem. 2003 May 1;89(1):19-37. doi: 10.1002/jcb.10496. J Cell Biochem. 2003. PMID: 12682905 Review.

156

Genomic profiles and predictive biological networks in oxidant-induced atherogenesis.

Johnson CD, Balagurunathan Y, Lu KP, Tadesse M, Falahatpisheh MH, Carroll RJ, Dougherty ER, Afshari CA, Ramos KS. Johnson CD, et al. Among authors: lu kp. Physiol Genomics. 2003 May 13;13(3):263-75. doi: 10.1152/physiolgenomics.00006.2003. Epub 2003 May 13. Physiol Genomics. 2003. PMID: 12657712

157

The prolyl isomerase Pin1 in breast development and cancer.

Wulf G, Ryo A, Liou YC, Lu KP. Wulf G, et al. Among authors: lu kp. Breast Cancer Res. 2003;5(2):76-82. doi: 10.1186/bcr572. Epub 2003 Jan 28. Breast Cancer Res. 2003. PMID: 12631385 Free PMC article. Review.

158

Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer.

Ryo A, Liou YC, Lu KP, Wulf G. Ryo A, et al. Among authors: lu kp. J Cell Sci. 2003 Mar 1;116(Pt 5):773-83. doi: 10.1242/jcs.00276. J Cell Sci. 2003. PMID: 12571275

159

Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease.

Lu KP, Liou YC, Vincent I. Lu KP, et al. Bioessays. 2003 Feb;25(2):174-81. doi: 10.1002/bies.10223. Bioessays. 2003. PMID: 12539244 Review.

160

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX. Zheng H, et al. Among authors: lu kp. Nature. 2002 Oct 24;419(6909):849-53. doi: 10.1038/nature01116. Epub 2002 Oct 2. Nature. 2002. PMID: 12397361

161

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage.

Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP. Wulf GM, et al. Among authors: lu kp. J Biol Chem. 2002 Dec 13;277(50):47976-9. doi: 10.1074/jbc.C200538200. Epub 2002 Oct 17. J Biol Chem. 2002. PMID: 12388558 Free article.

162

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.

Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP. Ryo A, et al. Among authors: lu kp. Mol Cell Biol. 2002 Aug;22(15):5281-95. doi: 10.1128/MCB.22.15.5281-5295.2002. Mol Cell Biol. 2002. PMID: 12101225 Free PMC article.

163

Pinning down proline-directed phosphorylation signaling.

Lu KP, Liou YC, Zhou XZ. Lu KP, et al. Trends Cell Biol. 2002 Apr;12(4):164-72. doi: 10.1016/s0962-8924(02)02253-5. Trends Cell Biol. 2002. PMID: 11978535 Review.

164

Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle.

Nakamura M, Zhou XZ, Kishi S, Lu KP. Nakamura M, et al. Among authors: lu kp. FEBS Lett. 2002 Mar 13;514(2-3):193-8. doi: 10.1016/s0014-5793(02)02363-3. FEBS Lett. 2002. PMID: 11943150 Free article.

165

Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1.

Kops O, Zhou XZ, Lu KP. Kops O, et al. Among authors: lu kp. FEBS Lett. 2002 Feb 27;513(2-3):305-11. doi: 10.1016/s0014-5793(02)02288-3. FEBS Lett. 2002. PMID: 11904169 Free article.

166

Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes.

Lu KP, Alejandro NF, Taylor KM, Joyce MM, Spencer TE, Ramos KS. Lu KP, et al. Atherosclerosis. 2002 Feb;160(2):273-80. doi: 10.1016/s0021-9150(01)00581-0. Atherosclerosis. 2002. PMID: 11849648

167

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.

Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP. Liou YC, et al. Among authors: lu kp. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40. doi: 10.1073/pnas.032404099. Epub 2002 Jan 22. Proc Natl Acad Sci U S A. 2002. PMID: 11805292 Free PMC article.

168

A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells.

Kishi S, Lu KP. Kishi S, et al. Among authors: lu kp. J Biol Chem. 2002 Mar 1;277(9):7420-9. doi: 10.1074/jbc.M111365200. Epub 2001 Dec 13. J Biol Chem. 2002. PMID: 11744712 Free article.

169

Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function.

Lu PJ, Zhou XZ, Liou YC, Noel JP, Lu KP. Lu PJ, et al. Among authors: lu kp. J Biol Chem. 2002 Jan 25;277(4):2381-4. doi: 10.1074/jbc.C100228200. Epub 2001 Nov 26. J Biol Chem. 2002. PMID: 11723108 Free article.

170

The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.

Zhou XZ, Lu KP. Zhou XZ, et al. Among authors: lu kp. Cell. 2001 Nov 2;107(3):347-59. doi: 10.1016/s0092-8674(01)00538-4. Cell. 2001. PMID: 11701125 Free article.

171

A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle.

Nakamura M, Zhou XZ, Kishi S, Kosugi I, Tsutsui Y, Lu KP. Nakamura M, et al. Among authors: lu kp. Curr Biol. 2001 Oct 2;11(19):1512-6. doi: 10.1016/s0960-9822(01)00456-0. Curr Biol. 2001. PMID: 11591318 Free article.

172

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.

Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP. Ryo A, et al. Among authors: lu kp. Nat Cell Biol. 2001 Sep;3(9):793-801. doi: 10.1038/ncb0901-793. Nat Cell Biol. 2001. PMID: 11533658

173

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.

Nakamura M, Zhou XZ, Lu KP. Nakamura M, et al. Among authors: lu kp. Curr Biol. 2001 Jul 10;11(13):1062-7. doi: 10.1016/s0960-9822(01)00297-4. Curr Biol. 2001. PMID: 11470413 Free article.

174

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. Wulf GM, et al. Among authors: lu kp. EMBO J. 2001 Jul 2;20(13):3459-72. doi: 10.1093/emboj/20.13.3459. EMBO J. 2001. PMID: 11432833 Free PMC article.

175

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.

Kishi S, Zhou XZ, Ziv Y, Khoo C, Hill DE, Shiloh Y, Lu KP. Kishi S, et al. Among authors: lu kp. J Biol Chem. 2001 Aug 3;276(31):29282-91. doi: 10.1074/jbc.M011534200. Epub 2001 May 25. J Biol Chem. 2001. PMID: 11375976 Free article.

176

Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1.

Liu W, Youn HD, Zhou XZ, Lu KP, Liu JO. Liu W, et al. Among authors: lu kp. FEBS Lett. 2001 May 11;496(2-3):105-8. doi: 10.1016/s0014-5793(01)02411-5. FEBS Lett. 2001. PMID: 11356192 Free article.

177

Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors.

Kishi S, Wulf G, Nakamura M, Lu KP. Kishi S, et al. Among authors: lu kp. Oncogene. 2001 Mar 22;20(12):1497-508. doi: 10.1038/sj.onc.1204229. Oncogene. 2001. PMID: 11313893

178

Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism.

Zhou XZ, Lu PJ, Wulf G, Lu KP. Zhou XZ, et al. Among authors: lu kp. Cell Mol Life Sci. 1999 Nov 30;56(9-10):788-806. doi: 10.1007/s000180050026. Cell Mol Life Sci. 1999. PMID: 11212339 Free PMC article. Review.

179

Functional conservation of phosphorylation-specific prolyl isomerases in plants.

Yao JL, Kops O, Lu PJ, Lu KP. Yao JL, et al. Among authors: lu kp. J Biol Chem. 2001 Apr 27;276(17):13517-23. doi: 10.1074/jbc.M007006200. Epub 2000 Dec 15. J Biol Chem. 2001. PMID: 11118438 Free article.

180

Functional replacement of the essential ESS1 in yeast by the plant parvulin DlPar13.

Metzner M, Stoller G, Rücknagel KP, Lu KP, Fischer G, Luckner M, Küllertz G. Metzner M, et al. Among authors: lu kp. J Biol Chem. 2001 Apr 27;276(17):13524-9. doi: 10.1074/jbc.M007005200. Epub 2000 Dec 15. J Biol Chem. 2001. PMID: 11118437 Free article.

181

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins.

Zhou XZ, Kops O, Werner A, Lu PJ, Shen M, Stoller G, Küllertz G, Stark M, Fischer G, Lu KP. Zhou XZ, et al. Among authors: lu kp. Mol Cell. 2000 Oct;6(4):873-83. doi: 10.1016/s1097-2765(05)00083-3. Mol Cell. 2000. PMID: 11090625 Free article.

182

Benzo(a)pyrene activates L1Md retrotransposon and inhibits DNA repair in vascular smooth muscle cells.

Lu KP, Hallberg LM, Tomlinson J, Ramos KS. Lu KP, et al. Mutat Res. 2000 Nov 6;454(1-2):35-44. doi: 10.1016/s0027-5107(00)00095-6. Mutat Res. 2000. PMID: 11035157

183

Structural basis for phosphoserine-proline recognition by group IV WW domains.

Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel JP. Verdecia MA, et al. Among authors: lu kp. Nat Struct Biol. 2000 Aug;7(8):639-43. doi: 10.1038/77929. Nat Struct Biol. 2000. PMID: 10932246

184

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.

Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP, Aaronson SA. Lee SW, et al. Among authors: lu kp. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8302-5. doi: 10.1073/pnas.150024397. Proc Natl Acad Sci U S A. 2000. PMID: 10890907 Free PMC article.

185

Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis.

Gerez L, Mohrmann K, van Raak M, Jongeneelen M, Zhou XZ, Lu KP, van Der Sluijs P. Gerez L, et al. Among authors: lu kp. Mol Biol Cell. 2000 Jul;11(7):2201-11. doi: 10.1091/mbc.11.7.2201. Mol Biol Cell. 2000. PMID: 10888662 Free PMC article.

186

Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism.

Lu KP. Lu KP. Prog Cell Cycle Res. 2000;4:83-96. doi: 10.1007/978-1-4615-4253-7_8. Prog Cell Cycle Res. 2000. PMID: 10740817 Review.

187

Actin-binding cellular proteins inside human immunodeficiency virus type 1.

Ott DE, Coren LV, Johnson DG, Kane BP, Sowder RC 2nd, Kim YD, Fisher RJ, Zhou XZ, Lu KP, Henderson LE. Ott DE, et al. Among authors: lu kp. Virology. 2000 Jan 5;266(1):42-51. doi: 10.1006/viro.1999.0075. Virology. 2000. PMID: 10612659 Free article.

188

Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases.

Mounsey JP, Lu KP, Patel MK, Chen ZH, Horne LT, John JE 3rd, Means AR, Jones LR, Moorman JR. Mounsey JP, et al. Among authors: lu kp. Biochim Biophys Acta. 1999 Sep 21;1451(2-3):305-18. doi: 10.1016/s0167-4889(99)00102-0. Biochim Biophys Acta. 1999. PMID: 10556585 Free article.

189

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. Lu PJ, et al. Among authors: lu kp. Nature. 1999 Jun 24;399(6738):784-8. doi: 10.1038/21650. Nature. 1999. PMID: 10391244

190

Function of WW domains as phosphoserine- or phosphothreonine-binding modules.

Lu PJ, Zhou XZ, Shen M, Lu KP. Lu PJ, et al. Among authors: lu kp. Science. 1999 Feb 26;283(5406):1325-8. doi: 10.1126/science.283.5406.1325. Science. 1999. PMID: 10037602

191

Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis.

Lu KP, Ramos KS. Lu KP, et al. Biochem Biophys Res Commun. 1998 Dec 30;253(3):828-33. doi: 10.1006/bbrc.1998.9866. Biochem Biophys Res Commun. 1998. PMID: 9918813

192

Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition.

Schutkowski M, Bernhardt A, Zhou XZ, Shen M, Reimer U, Rahfeld JU, Lu KP, Fischer G. Schutkowski M, et al. Among authors: lu kp. Biochemistry. 1998 Apr 21;37(16):5566-75. doi: 10.1021/bi973060z. Biochemistry. 1998. PMID: 9548941

193

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.

Shen M, Stukenberg PT, Kirschner MW, Lu KP. Shen M, et al. Among authors: lu kp. Genes Dev. 1998 Mar 1;12(5):706-20. doi: 10.1101/gad.12.5.706. Genes Dev. 1998. PMID: 9499405 Free PMC article.

194

Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis.

Shen M, Haggblom C, Vogt M, Hunter T, Lu KP. Shen M, et al. Among authors: lu kp. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13618-23. doi: 10.1073/pnas.94.25.13618. Proc Natl Acad Sci U S A. 1997. PMID: 9391075 Free PMC article.

195

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.

Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Yaffe MB, et al. Among authors: lu kp. Science. 1997 Dec 12;278(5345):1957-60. doi: 10.1126/science.278.5345.1957. Science. 1997. PMID: 9395400

196

Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent.

Ranganathan R, Lu KP, Hunter T, Noel JP. Ranganathan R, et al. Among authors: lu kp. Cell. 1997 Jun 13;89(6):875-86. doi: 10.1016/s0092-8674(00)80273-1. Cell. 1997. PMID: 9200606 Free article.

197

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. Songyang Z, et al. Among authors: lu kp. Mol Cell Biol. 1996 Nov;16(11):6486-93. doi: 10.1128/MCB.16.11.6486. Mol Cell Biol. 1996. PMID: 8887677 Free PMC article.

198

A human peptidyl-prolyl isomerase essential for regulation of mitosis.

Lu KP, Hanes SD, Hunter T. Lu KP, et al. Nature. 1996 Apr 11;380(6574):544-7. doi: 10.1038/380544a0. Nature. 1996. PMID: 8606777

199

Evidence for a NIMA-like mitotic pathway in vertebrate cells.

Lu KP, Hunter T. Lu KP, et al. Cell. 1995 May 5;81(3):413-24. doi: 10.1016/0092-8674(95)90394-1. Cell. 1995. PMID: 7736593 Free article.

200

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.

Lu KP, Hunter T. Lu KP, et al. Prog Cell Cycle Res. 1995;1:187-205. doi: 10.1007/978-1-4615-1809-9_15. Prog Cell Cycle Res. 1995. PMID: 9552363 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Results by year

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

212 results

Results by year

Search Page

Filters

My Custom Filters

Results by year

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

212 results

Results by year