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Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.
Tao Y, Ruan J, Yeh SH, Lu X, Wang Y, Zhai W, Cai J, Ling S, Gong Q, Chong Z, Qu Z, Li Q, Liu J, Yang J, Zheng C, Zeng C, Wang HY, Zhang J, Wang SH, Hao L, Dong L, Li W, Sun M, Zou W, Yu C, Li C, Liu G, Jiang L, Xu J, Huang H, Li C, Mi S, Zhang B, Chen B, Zhao W, Hu S, Zhuang SM, Shen Y, Shi S, Brown C, White KP, Chen DS, Chen PJ, Wu CI. Tao Y, et al. Among authors: lu x. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12042-7. doi: 10.1073/pnas.1108715108. Epub 2011 Jul 5. Proc Natl Acad Sci U S A. 2011. PMID: 21730188 Free PMC article.
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.
Ling S, Hu Z, Yang Z, Yang F, Li Y, Lin P, Chen K, Dong L, Cao L, Tao Y, Hao L, Chen Q, Gong Q, Wu D, Li W, Zhao W, Tian X, Hao C, Hungate EA, Catenacci DV, Hudson RR, Li WH, Lu X, Wu CI. Ling S, et al. Among authors: lu x. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6496-505. doi: 10.1073/pnas.1519556112. Epub 2015 Nov 11. Proc Natl Acad Sci U S A. 2015. PMID: 26561581 Free PMC article.
Evolution under Spatially Heterogeneous Selection in Solid Tumors.
Li G, Yang Z, Wu D, Liu S, Li X, Li T, Li Y, Liang L, Zou W, Wu CI, Wang HY, Lu X. Li G, et al. Among authors: lu x. Mol Biol Evol. 2022 Jan 7;39(1):msab335. doi: 10.1093/molbev/msab335. Mol Biol Evol. 2022. PMID: 34850073 Free PMC article.
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