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Breastmilk feeding and lipoprotein profile in adolescents born preterm: follow-up of a prospective randomised study.
Singhal A, Cole TJ, Fewtrell M, Lucas A. Singhal A, et al. Among authors: lucas a. Lancet. 2004 May 15;363(9421):1571-8. doi: 10.1016/S0140-6736(04)16198-9. Lancet. 2004. PMID: 15145629 Clinical Trial.
We followed up 216 participants at age 13-16 years and measured ratio of low-density to high-density lipoprotein cholesterol (LDL to HDL), ratio of apolipoprotein B to apolipoprotein A-1 (apoB to apoA-1), and concentration of C-reactive protein (CRP; a measure of th …
We followed up 216 participants at age 13-16 years and measured ratio of low-density to high-density lipoprotein cholesterol (LDL to HDL), r …
Breast Milk Consumption in Preterm Neonates and Cardiac Shape in Adulthood.
Lewandowski AJ, Lamata P, Francis JM, Piechnik SK, Ferreira VM, Boardman H, Neubauer S, Singhal A, Leeson P, Lucas A. Lewandowski AJ, et al. Among authors: lucas a. Pediatrics. 2016 Jul;138(1):e20160050. doi: 10.1542/peds.2016-0050. Epub 2016 Jun 14. Pediatrics. 2016. PMID: 27302980 Free PMC article. Clinical Trial.
METHODS: A total of 926 preterm-born infants originally took part in a randomized controlled trial of postnatal milk-feeding regimens between 1982 and 1985 across 5 different UK centers. ...As a comparison group, we recruited an additional 102 individuals bor …
METHODS: A total of 926 preterm-born infants originally took part in a randomized controlled trial of postnatal milk-feeding r …
Elevated blood pressure in preterm-born offspring associates with a distinct antiangiogenic state and microvascular abnormalities in adult life.
Lewandowski AJ, Davis EF, Yu G, Digby JE, Boardman H, Whitworth P, Singhal A, Lucas A, McCormick K, Shore AC, Leeson P. Lewandowski AJ, et al. Among authors: lucas a. Hypertension. 2015 Mar;65(3):607-14. doi: 10.1161/HYPERTENSIONAHA.114.04662. Epub 2014 Dec 22. Hypertension. 2015. PMID: 25534704
A panel of circulating biomarkers, including soluble endoglin and soluble fms-like tyrosine kinase-1, were compared between groups and related to perinatal history and adult cardiovascular risk. ...There was a specific graded association between soluble endoglin and
A panel of circulating biomarkers, including soluble endoglin and soluble fms-like tyrosine kinase-1, were compared between groups an
Dietary nucleotides and fecal microbiota in formula-fed infants: a randomized controlled trial.
Singhal A, Macfarlane G, Macfarlane S, Lanigan J, Kennedy K, Elias-Jones A, Stephenson T, Dudek P, Lucas A. Singhal A, et al. Among authors: lucas a. Am J Clin Nutr. 2008 Jun;87(6):1785-92. doi: 10.1093/ajcn/87.6.1785. Am J Clin Nutr. 2008. PMID: 18541569 Clinical Trial.
A higher nucleotide intake may also have favorable effects on the fecal microbial composition and incidence of diarrhea in infancy. ...DESIGN: Oligonucleotide probes were used to measure bacterial genus-specific 16S ribosomal RNA in stools of a subset of infants (me
A higher nucleotide intake may also have favorable effects on the fecal microbial composition and incidence of diarrhea in infancy. .
Neurodevelopment in children born small for gestational age: a randomized trial of nutrient-enriched versus standard formula and comparison with a reference breastfed group.
Morley R, Fewtrell MS, Abbott RA, Stephenson T, MacFadyen U, Lucas A. Morley R, et al. Among authors: lucas a. Pediatrics. 2004 Mar;113(3 Pt 1):515-21. doi: 10.1542/peds.113.3.515. Pediatrics. 2004. PMID: 14993543 Clinical Trial.
OBJECTIVE: Many studies have shown that children born small for gestational age (SGA) are at a neurodevelopmental disadvantage. ...DESIGN: A randomized, controlled trial of standard term-infant (n = 147) or nutrient-enriched (n = 152) formula for the first 9 months. …
OBJECTIVE: Many studies have shown that children born small for gestational age (SGA) are at a neurodevelopmental disadvantage. ...DE …
Infant nutrition and stereoacuity at age 4-6 y.
Singhal A, Morley R, Cole TJ, Kennedy K, Sonksen P, Isaacs E, Fewtrell M, Elias-Jones A, Stephenson T, Lucas A. Singhal A, et al. Among authors: lucas a. Am J Clin Nutr. 2007 Jan;85(1):152-9. doi: 10.1093/ajcn/85.1.152. Am J Clin Nutr. 2007. PMID: 17209191 Clinical Trial.
A higher concentration of docosahexaneoic acid (DHA) in breast milk than in formula has been proposed as one explanation for this association and as a rationale for adding DHA to infant formula, but few long-term data support this possibility. ...In the formula-fed
A higher concentration of docosahexaneoic acid (DHA) in breast milk than in formula has been proposed as one explanation for this ass
10-year cognition in preterms after random assignment to fatty acid supplementation in infancy.
Isaacs EB, Ross S, Kennedy K, Weaver LT, Lucas A, Fewtrell MS. Isaacs EB, et al. Among authors: lucas a. Pediatrics. 2011 Oct;128(4):e890-8. doi: 10.1542/peds.2010-3153. Epub 2011 Sep 19. Pediatrics. 2011. PMID: 21930549 Clinical Trial.
CONCLUSIONS: The results of this post-9-year cognitive follow-up study in a randomized trial of LCPUFA-supplemented formula for preterm infants suggest no overall group effects but indicate that gender-specific and diet-specific effects may exist. The data provide some evi …
CONCLUSIONS: The results of this post-9-year cognitive follow-up study in a randomized trial of LCPUFA-supplemented formula for prete …
Aluminium exposure from parenteral nutrition in preterm infants and later health outcomes during childhood and adolescence.
Fewtrell MS, Edmonds CJ, Isaacs E, Bishop NJ, Lucas A. Fewtrell MS, et al. Among authors: lucas a. Proc Nutr Soc. 2011 Aug;70(3):299-304. doi: 10.1017/S0029665111000498. Proc Nutr Soc. 2011. PMID: 21781356 Clinical Trial.
Later health effects of neonatal intravenous aluminium exposure were investigated in a randomised trial comparing standard PN solutions with solutions specially sourced for low aluminium content. ...
Later health effects of neonatal intravenous aluminium exposure were investigated in a randomised trial comparing standard PN solutio …
The effect of intrauterine growth on verbal IQ scores in childhood: a study of monozygotic twins.
Edmonds CJ, Isaacs EB, Cole TJ, Rogers MH, Lanigan J, Singhal A, Birbara T, Gringras P, Denton J, Lucas A. Edmonds CJ, et al. Among authors: lucas a. Pediatrics. 2010 Nov;126(5):e1095-101. doi: 10.1542/peds.2008-3684. Epub 2010 Oct 11. Pediatrics. 2010. PMID: 20937654
METHODS: A total of 71 monozygotic twin pairs (aged 7 years 11 months to 17 years 3 months) participated. The Wechsler Intelligence Scale for Children, Third Edition, was administered, and verbal IQ (VIQ) and performance IQ (PIQ) scores were calculated. ...CONCLUSIONS: Our …
METHODS: A total of 71 monozygotic twin pairs (aged 7 years 11 months to 17 years 3 months) participated. The Wechsler Intelligence S …
Nutrition in infancy and long-term risk of obesity: evidence from 2 randomized controlled trials.
Singhal A, Kennedy K, Lanigan J, Fewtrell M, Cole TJ, Stephenson T, Elias-Jones A, Weaver LT, Ibhanesebhor S, MacDonald PD, Bindels J, Lucas A. Singhal A, et al. Among authors: lucas a. Am J Clin Nutr. 2010 Nov;92(5):1133-44. doi: 10.3945/ajcn.2010.29302. Epub 2010 Sep 29. Am J Clin Nutr. 2010. PMID: 20881062 Clinical Trial.
DESIGN: We reviewed a subset of children (n = 153 of 299 in study 1 and 90 of 246 in study 2) randomly assigned at birth to receive either a control formula or a nutrient-enriched formula (which contained 28-43% more protein and 6-12% more energy than the con …
DESIGN: We reviewed a subset of children (n = 153 of 299 in study 1 and 90 of 246 in study 2) randomly assigned at birth to receive e …
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