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Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Garcia LR, Tenev T, Newman R, Haich RO, Liccardi G, John SW, Annibaldi A, Yu L, Pardo M, Young SN, Fitzgibbon C, Fernando W, Guppy N, Kim H, Liang LY, Lucet IS, Kueh A, Roxanis I, Gazinska P, Sims M, Smyth T, Ward G, Bertin J, Beal AM, Geddes B, Choudhary JS, Murphy JM, Aurelia Ball K, Upton JW, Meier P. Garcia LR, et al. Among authors: lucet is. Nat Commun. 2021 Jun 7;12(1):3364. doi: 10.1038/s41467-021-23474-5. Nat Commun. 2021. PMID: 34099649 Free PMC article.
Regulation of Janus kinases by SOCS proteins.
Kershaw NJ, Murphy JM, Lucet IS, Nicola NA, Babon JJ. Kershaw NJ, et al. Among authors: lucet is. Biochem Soc Trans. 2013 Aug;41(4):1042-7. doi: 10.1042/BST20130077. Biochem Soc Trans. 2013. PMID: 23863176 Free PMC article. Review.
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Among authors: lucet is. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422 Free article.
The molecular regulation of Janus kinase (JAK) activation.
Babon JJ, Lucet IS, Murphy JM, Nicola NA, Varghese LN. Babon JJ, et al. Among authors: lucet is. Biochem J. 2014 Aug 15;462(1):1-13. doi: 10.1042/BJ20140712. Biochem J. 2014. PMID: 25057888 Free PMC article. Review.
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J. Hildebrand JM, et al. Among authors: lucet is. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. doi: 10.1073/pnas.1408987111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288762 Free PMC article.
65 results