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From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. Gaisina IN, et al. Among authors: luchini dn. J Med Chem. 2009 Apr 9;52(7):1853-63. doi: 10.1021/jm801317h. J Med Chem. 2009. PMID: 19338355 Free PMC article.
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