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Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Steubler V, Erdinger S, Back MK, Ludewig S, Fässler D, Richter M, Han K, Slomianka L, Amrein I, von Engelhardt J, Wolfer DP, Korte M, Müller UC. Steubler V, et al. Among authors: ludewig s. EMBO J. 2021 Jun 15;40(12):e107471. doi: 10.15252/embj.2020107471. Epub 2021 May 19. EMBO J. 2021. PMID: 34008862 Free PMC article.
Amyloid, APP, and Electrical Activity of the Brain.
Hefter D, Ludewig S, Draguhn A, Korte M. Hefter D, et al. Among authors: ludewig s. Neuroscientist. 2020 Jun;26(3):231-251. doi: 10.1177/1073858419882619. Epub 2019 Nov 29. Neuroscientist. 2020. PMID: 31779518 Free PMC article. Review.
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC. Richter MC, et al. Among authors: ludewig s. EMBO J. 2018 Jun 1;37(11):e98335. doi: 10.15252/embj.201798335. Epub 2018 Apr 16. EMBO J. 2018. PMID: 29661886 Free PMC article.
70 results