Lues I - Search Results

1

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study.

Scheltens P, Hallikainen M, Grimmer T, Duning T, Gouw AA, Teunissen CE, Wink AM, Maruff P, Harrison J, van Baal CM, Bruins S, Lues I, Prins ND. Scheltens P, et al. Among authors: lues i. Alzheimers Res Ther. 2018 Oct 12;10(1):107. doi: 10.1186/s13195-018-0431-6. Alzheimers Res Ther. 2018. PMID: 30309389 Free PMC article. Clinical Trial.

2

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.

Bridel C, Hoffmann T, Meyer A, Durieux S, Koel-Simmelink MA, Orth M, Scheltens P, Lues I, Teunissen CE. Bridel C, et al. Among authors: lues i. Alzheimers Res Ther. 2017 Jun 6;9(1):38. doi: 10.1186/s13195-017-0266-6. Alzheimers Res Ther. 2017. PMID: 28587659 Free PMC article.

3

In pursuit of a sensitive EEG functional connectivity outcome measure for clinical trials in Alzheimer's disease.

Briels CT, Stam CJ, Scheltens P, Bruins S, Lues I, Gouw AA. Briels CT, et al. Among authors: lues i. Clin Neurophysiol. 2020 Jan;131(1):88-95. doi: 10.1016/j.clinph.2019.09.014. Epub 2019 Nov 4. Clin Neurophysiol. 2020. PMID: 31759193 Clinical Trial.

4

Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy.

Hoffmann T, Meyer A, Heiser U, Kurat S, Böhme L, Kleinschmidt M, Bühring KU, Hutter-Paier B, Farcher M, Demuth HU, Lues I, Schilling S. Hoffmann T, et al. Among authors: lues i. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130. doi: 10.1124/jpet.117.240614. Epub 2017 Apr 26. J Pharmacol Exp Ther. 2017. PMID: 28446518

5

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.

Lues I, Weber F, Meyer A, Bühring U, Hoffmann T, Kühn-Wache K, Manhart S, Heiser U, Pokorny R, Chiesa J, Glund K. Lues I, et al. Alzheimers Dement (N Y). 2015 Oct 3;1(3):182-195. doi: 10.1016/j.trci.2015.08.002. eCollection 2015 Nov. Alzheimers Dement (N Y). 2015. PMID: 29854937 Free PMC article.

6

Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice.

Hoffmann T, Rahfeld JU, Schenk M, Ponath F, Makioka K, Hutter-Paier B, Lues I, Lemere CA, Schilling S. Hoffmann T, et al. Among authors: lues i. Int J Mol Sci. 2021 Oct 30;22(21):11791. doi: 10.3390/ijms222111791. Int J Mol Sci. 2021. PMID: 34769222 Free PMC article.

7

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice.

Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA. Crehan H, et al. Among authors: lues i. Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8. Alzheimers Res Ther. 2020. PMID: 31931873 Free PMC article.

8

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.

Hartlage-Rübsamen M, Bluhm A, Piechotta A, Linnert M, Rahfeld JU, Demuth HU, Lues I, Kuhn PH, Lichtenthaler SF, Roßner S, Höfling C. Hartlage-Rübsamen M, et al. Among authors: lues i. Molecules. 2018 Apr 17;23(4):924. doi: 10.3390/molecules23040924. Molecules. 2018. PMID: 29673150 Free PMC article.

9

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy.

Piechotta A, Parthier C, Kleinschmidt M, Gnoth K, Pillot T, Lues I, Demuth HU, Schilling S, Rahfeld JU, Stubbs MT. Piechotta A, et al. Among authors: lues i. J Biol Chem. 2017 Jul 28;292(30):12713-12724. doi: 10.1074/jbc.M117.777839. Epub 2017 Jun 16. J Biol Chem. 2017. PMID: 28623233 Free PMC article.

10

Passive Aβ Immunotherapy: Current Achievements and Future Perspectives.

Schilling S, Rahfeld JU, Lues I, Lemere CA. Schilling S, et al. Among authors: lues i. Molecules. 2018 May 3;23(5):1068. doi: 10.3390/molecules23051068. Molecules. 2018. PMID: 29751505 Free PMC article. Review.

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