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Synthesis and cellular studies of an octa-anionic 5,10,15,20-tetra[3,5-(nido-carboranylmethyl)phenyl]porphyrin (H(2)OCP) for application in BNCT.
Gottumukkala V, Luguya R, Fronczek FR, Vicente MG. Gottumukkala V, et al. Among authors: luguya r. Bioorg Med Chem. 2005 Mar 1;13(5):1633-40. doi: 10.1016/j.bmc.2004.12.016. Bioorg Med Chem. 2005. PMID: 15698781
Synthesis of novel carboranylchlorins with dual application in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT).
Luguya R, Fronczek FR, Smith KM, Vicente MG. Luguya R, et al. Appl Radiat Isot. 2004 Nov;61(5):1117-23. doi: 10.1016/j.apradiso.2004.05.068. Appl Radiat Isot. 2004. PMID: 15308202
Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer.
Maderna A, Huertas R, Hawthorne MF, Luguya R, Vicente MG. Maderna A, et al. Among authors: luguya r. Chem Commun (Camb). 2002 Aug 21;(16):1784-5. doi: 10.1039/b203730k. Chem Commun (Camb). 2002. PMID: 12196998
Effect of overall charge and charge distribution on cellular uptake, distribution and phototoxicity of cationic porphyrins in HEp2 cells.
Jensen TJ, Vicente MG, Luguya R, Norton J, Fronczek FR, Smith KM. Jensen TJ, et al. Among authors: luguya r. J Photochem Photobiol B. 2010 Aug 2;100(2):100-11. doi: 10.1016/j.jphotobiol.2010.05.007. Epub 2010 May 23. J Photochem Photobiol B. 2010. PMID: 20558079 Free PMC article.
Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors.
Luguya R, Jensen TJ, Smith KM, Vicente MG. Luguya R, et al. Bioorg Med Chem. 2006 Sep 1;14(17):5890-7. doi: 10.1016/j.bmc.2006.05.026. Epub 2006 Jun 5. Bioorg Med Chem. 2006. PMID: 16753299
Localization and photodynamic efficacy of two cationic porphyrins varying in charge distributions.
Kessel D, Luguya R, Vicente MG. Kessel D, et al. Among authors: luguya r. Photochem Photobiol. 2003 Nov;78(5):431-5. doi: 10.1562/0031-8655(2003)078<0431:lapeot>;2. Photochem Photobiol. 2003. PMID: 14653572