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[No authors listed] [No authors listed] PMID: 27579161
Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations.
Taberlay PC, Achinger-Kawecka J, Lun AT, Buske FA, Sabir K, Gould CM, Zotenko E, Bert SA, Giles KA, Bauer DC, Smyth GK, Stirzaker C, O'Donoghue SI, Clark SJ. Taberlay PC, et al. Genome Res. 2016 Jun;26(6):719-31. doi: 10.1101/gr.201517.115. Epub 2016 Apr 6. Genome Res. 2016. PMID: 27053337 Free PMC article.
Interestingly, a large proportion of the new cancer-specific domain boundaries occur at regions that display copy-number variation. ...Change in domain structure is also accompanied by novel cancer-specific chromatin interactions within the TADs that are enriched at
Interestingly, a large proportion of the new cancer-specific domain boundaries occur at regions that display copy-number variation. . …
[No authors listed] [No authors listed] PMID: 26918120
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.
Fu NY, Rios AC, Pal B, Soetanto R, Lun AT, Liu K, Beck T, Best SA, Vaillant F, Bouillet P, Strasser A, Preiss T, Smyth GK, Lindeman GJ, Visvader JE. Fu NY, et al. Nat Cell Biol. 2015 Apr;17(4):365-75. doi: 10.1038/ncb3117. Epub 2015 Mar 2. Nat Cell Biol. 2015. PMID: 25730472
Mcl-1 was found to be essential at multiple developmental stages including morphogenesis in puberty and alveologenesis in pregnancy. ...Profound upregulation of the Mcl-1 protein was evident in alveolar cells at the switch to lactation, and Mcl-1 deficiency impaired …
Mcl-1 was found to be essential at multiple developmental stages including morphogenesis in puberty and alveologenesis in pregnancy. …
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