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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Lupi R, et al. Diabetes. 2002 May;51(5):1437-42. doi: 10.2337/diabetes.51.5.1437. Diabetes. 2002. PMID: 11978640
The pancreatic beta-cell in human Type 2 diabetes.
Marchetti P, Del Prato S, Lupi R, Del Guerra S. Marchetti P, et al. Among authors: lupi r. Nutr Metab Cardiovasc Dis. 2006 Mar;16 Suppl 1:S3-6. doi: 10.1016/j.numecd.2005.10.017. Epub 2006 Feb 9. Nutr Metab Cardiovasc Dis. 2006. PMID: 16530127 Review.
147 results