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1,298 results

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Page 1
Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: Update of the guidelines for lupus anticoagulant detection and interpretation.
Devreese KMJ, de Groot PG, de Laat B, Erkan D, Favaloro EJ, Mackie I, Martinuzzo M, Ortel TL, Pengo V, Rand JH, Tripodi A, Wahl D, Cohen H. Devreese KMJ, et al. J Thromb Haemost. 2020 Nov;18(11):2828-2839. doi: 10.1111/jth.15047. J Thromb Haemost. 2020. PMID: 33462974 Free article.
This guidance focuses on methodological aspects of lupus anticoagulant (LA) testing, as well as interpretation of results for clinicians. ...Also, routine coagulation tests are advised to obtain more information on the coagulation background of the pat …
This guidance focuses on methodological aspects of lupus anticoagulant (LA) testing, as well as interpretation of results for …
Lupus anticoagulant test persistence over time and its associations with future thrombotic events.
Colling ME, Ay C, Kraemmer D, Koder S, Quehenberger P, Pabinger I, Posch F, Gebhart J. Colling ME, et al. Blood Adv. 2022 May 24;6(10):2957-2966. doi: 10.1182/bloodadvances.2021006011. Blood Adv. 2022. PMID: 35042230 Free PMC article.
Data on lupus anticoagulant (LA) test stability in patients persistently positive for LA are limited, and its implications on clinical outcomes are lacking. ...The majority of patients with available follow-up after a negative LA test (n = 41) had at l …
Data on lupus anticoagulant (LA) test stability in patients persistently positive for LA are limited, and its implicati …
Lupus anticoagulant testing.
Moffat K, Raby A, Crowther M. Moffat K, et al. Methods Mol Biol. 2013;992:97-108. doi: 10.1007/978-1-62703-339-8_7. Methods Mol Biol. 2013. PMID: 23546707
In clinical laboratory practice, antiphospholipid antibody evaluations usually consist of a combination of the following: anticardiolipin antibody assay, anti-beta 2 glycoprotein I assay, and at least two lupus anticoagulant assays with an appropriate confirmatory …
In clinical laboratory practice, antiphospholipid antibody evaluations usually consist of a combination of the following: anticardiolipin an …
Lupus Anticoagulant Testing: Taipan Snake Venom Time with Ecarin Time as Confirmatory Test.
Moore GW. Moore GW. Methods Mol Biol. 2023;2663:263-274. doi: 10.1007/978-1-0716-3175-1_16. Methods Mol Biol. 2023. PMID: 37204716
Oscutarin C in Coastal Taipan venom is phospholipid- and Ca(2+)-dependent, so the venom is used in a dilute phospholipid design as an LA screening test called the Taipan snake venom time (TSVT). The ecarin fraction of Indian saw-scaled viper venom is cofactor-indepe …
Oscutarin C in Coastal Taipan venom is phospholipid- and Ca(2+)-dependent, so the venom is used in a dilute phospholipid design as an …
Lupus anticoagulant and antiprothrombin antibodies: embracing the future.
Pengo V, Pozzi N. Pengo V, et al. J Thromb Haemost. 2025 Jul;23(7):2262-2269. doi: 10.1016/j.jtha.2025.03.029. Epub 2025 Apr 6. J Thromb Haemost. 2025. PMID: 40199445 Free article. Review.
Lupus anticoagulant (LAC) is a well-known laboratory test used to explore potential reasons for the prolongation of phospholipid-dependent coagulation tests. An extended clotting time in a coagulation test typically suggests a bleeding te …
Lupus anticoagulant (LAC) is a well-known laboratory test used to explore potential reasons for the prolongation of pho …
Lupus Anticoagulant Testing: Dilute Prothrombin Time (dPT).
Moore GW. Moore GW. Methods Mol Biol. 2023;2663:275-288. doi: 10.1007/978-1-0716-3175-1_17. Methods Mol Biol. 2023. PMID: 37204717
Lupus anticoagulants (LA) rarely affect routine prothrombin time assays because the high phospholipid (PL) content in thromboplastin reagents tends to overwhelm the antibodies. ...Presence of an LA cannot be deduced from an elevated screening test alone since other …
Lupus anticoagulants (LA) rarely affect routine prothrombin time assays because the high phospholipid (PL) content in thromboplastin …
Optimisation of lupus anticoagulant tests: should test samples always be mixed with normal plasma?
Pennings MT, De Groot PG, Meijers JC, Huisman A, Derksen RH, Urbanus RT. Pennings MT, et al. Thromb Haemost. 2014 Oct;112(4):736-42. doi: 10.1160/TH14-02-0122. Epub 2014 Jul 10. Thromb Haemost. 2014. PMID: 25008787
Coagulation factor deficiencies are thought to interfere with the detection of the phospholipid-dependent coagulation inhibitor known as lupus anticoagulant (LA). ...As a result, VKA treatment is often temporarily discontinued to allow LA assess …
Coagulation factor deficiencies are thought to interfere with the detection of the phospholipid-dependent coagulation inhib …
Lupus Anticoagulant Testing in Challenging Situations: Navigating Complexities.
Devreese KMJ. Devreese KMJ. Int J Lab Hematol. 2026 Apr;48(2):281-294. doi: 10.1111/ijlh.14490. Epub 2025 May 16. Int J Lab Hematol. 2026. PMID: 40376991 Review.
The laboratory diagnosis of antiphospholipid syndrome (APS) relies on detecting persistent antiphospholipid antibodies (aPL), including lupus anticoagulant (LA) as one of the three laboratory criteria. LA is a well-established risk factor in APS and the cornerstone …
The laboratory diagnosis of antiphospholipid syndrome (APS) relies on detecting persistent antiphospholipid antibodies (aPL), including l …
1,298 results