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Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.
Barucker C, Bittner HJ, Chang PK, Cameron S, Hancock MA, Liebsch F, Hossain S, Harmeier A, Shaw H, Charron FM, Gensler M, Dembny P, Zhuang W, Schmitz D, Rabe JP, Rao Y, Lurz R, Hildebrand PW, McKinney RA, Multhaup G. Barucker C, et al. Among authors: lurz r. Sci Rep. 2015 Oct 29;5:15410. doi: 10.1038/srep15410. Sci Rep. 2015. PMID: 26510576 Free PMC article.
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.
Kaden D, Harmeier A, Weise C, Munter LM, Althoff V, Rost BR, Hildebrand PW, Schmitz D, Schaefer M, Lurz R, Skodda S, Yamamoto R, Arlt S, Finckh U, Multhaup G. Kaden D, et al. Among authors: lurz r. EMBO Mol Med. 2012 Jul;4(7):647-59. doi: 10.1002/emmm.201200239. Epub 2012 Apr 19. EMBO Mol Med. 2012. PMID: 22514144 Free PMC article.
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE. Bieschke J, et al. Among authors: lurz r. Nat Chem Biol. 2011 Nov 20;8(1):93-101. doi: 10.1038/nchembio.719. Nat Chem Biol. 2011. PMID: 22101602
Functional amyloids as inhibitors of plasmid DNA replication.
Molina-García L, Gasset-Rosa F, Moreno-Del Álamo M, Fernández-Tresguerres ME, Moreno-Díaz de la Espina S, Lurz R, Giraldo R. Molina-García L, et al. Among authors: lurz r. Sci Rep. 2016 May 5;6:25425. doi: 10.1038/srep25425. Sci Rep. 2016. PMID: 27147472 Free PMC article.
207 results