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Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
Moreira FA, Grieb M, Lutz B. Moreira FA, et al. Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):133-44. doi: 10.1016/j.beem.2008.09.003. Best Pract Res Clin Endocrinol Metab. 2009. PMID: 19285266 Review.
Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.
Pagotto U, Marsicano G, Fezza F, Theodoropoulou M, Grübler Y, Stalla J, Arzberger T, Milone A, Losa M, Di Marzo V, Lutz B, Stalla GK. Pagotto U, et al. J Clin Endocrinol Metab. 2001 Jun;86(6):2687-96. doi: 10.1210/jcem.86.6.7565. J Clin Endocrinol Metab. 2001. PMID: 11397872
The endogenous cannabinoid system controls extinction of aversive memories.
Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B. Marsicano G, et al. Nature. 2002 Aug 1;418(6897):530-4. doi: 10.1038/nature00839. Nature. 2002. PMID: 12152079
Endogenous cannabinoid system as a modulator of food intake.
Cota D, Marsicano G, Lutz B, Vicennati V, Stalla GK, Pasquali R, Pagotto U. Cota D, et al. Int J Obes Relat Metab Disord. 2003 Mar;27(3):289-301. doi: 10.1038/sj.ijo.0802250. Int J Obes Relat Metab Disord. 2003. PMID: 12629555 Review.
Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon.
Storr M, Sibaev A, Marsicano G, Lutz B, Schusdziarra V, Timmermans JP, Allescher HD. Storr M, et al. Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G110-7. doi: 10.1152/ajpgi.00148.2003. Epub 2003 Jul 31. Am J Physiol Gastrointest Liver Physiol. 2004. PMID: 12893627
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutiérrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, Lutz B. Marsicano G, et al. Science. 2003 Oct 3;302(5642):84-8. doi: 10.1126/science.1088208. Science. 2003. PMID: 14526074
Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity.
Khaspekov LG, Brenz Verca MS, Frumkina LE, Hermann H, Marsicano G, Lutz B. Khaspekov LG, et al. Eur J Neurosci. 2004 Apr;19(7):1691-8. doi: 10.1111/j.1460-9568.2004.03285.x. Eur J Neurosci. 2004. PMID: 15078543
The endogenous cannabinoid system protects against colonic inflammation.
Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri GL, Sibaev A, Storr M, Lutz B. Massa F, et al. J Clin Invest. 2004 Apr;113(8):1202-9. doi: 10.1172/JCI19465. J Clin Invest. 2004. PMID: 15085199 Free PMC article.
Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system.
Bayatti N, Hermann H, Lutz B, Behl C. Bayatti N, et al. Endocrinology. 2005 Mar;146(3):1205-13. doi: 10.1210/en.2004-1154. Epub 2004 Dec 9. Endocrinology. 2005. PMID: 15591144
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