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Synthesis of ( R)- and ( S)-Fmoc-Protected Diethylene Glycol Gamma PNA Monomers with High Optical Purity.
Hsieh WC, Shaikh AY, Perera JDR, Thadke SA, Ly DH. Hsieh WC, et al. Among authors: ly dh. J Org Chem. 2019 Feb 1;84(3):1276-1287. doi: 10.1021/acs.joc.8b02714. Epub 2019 Jan 22. J Org Chem. 2019. PMID: 30608165
Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility.
Sahu B, Sacui I, Rapireddy S, Zanotti KJ, Bahal R, Armitage BA, Ly DH. Sahu B, et al. Among authors: ly dh. J Org Chem. 2011 Jul 15;76(14):5614-27. doi: 10.1021/jo200482d. Epub 2011 Jun 15. J Org Chem. 2011. PMID: 21619025 Free PMC article.
Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-peptide nucleic acids (gammaGPNAs).
Sahu B, Chenna V, Lathrop KL, Thomas SM, Zon G, Livak KJ, Ly DH. Sahu B, et al. Among authors: ly dh. J Org Chem. 2009 Feb 20;74(4):1509-16. doi: 10.1021/jo802211n. J Org Chem. 2009. PMID: 19161276 Free PMC article.
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.
Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. Bahal R, et al. Among authors: ly dh. Nat Commun. 2016 Oct 26;7:13304. doi: 10.1038/ncomms13304. Nat Commun. 2016. PMID: 27782131 Free PMC article.
Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy.
Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM. Gupta A, et al. Among authors: ly dh. Mol Ther Nucleic Acids. 2017 Dec 15;9:111-119. doi: 10.1016/j.omtn.2017.09.001. Epub 2017 Sep 12. Mol Ther Nucleic Acids. 2017. PMID: 29246289 Free PMC article.
Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.
Thomas SM, Sahu B, Rapireddy S, Bahal R, Wheeler SE, Procopio EM, Kim J, Joyce SC, Contrucci S, Wang Y, Chiosea SI, Lathrop KL, Watkins S, Grandis JR, Armitage BA, Ly DH. Thomas SM, et al. Among authors: ly dh. ACS Chem Biol. 2013 Feb 15;8(2):345-52. doi: 10.1021/cb3003946. Epub 2012 Nov 9. ACS Chem Biol. 2013. PMID: 23113581 Free PMC article.
High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element.
Roy S, Tanious FA, Wilson WD, Ly DH, Armitage BA. Roy S, et al. Among authors: ly dh. Biochemistry. 2007 Sep 18;46(37):10433-43. doi: 10.1021/bi700854r. Epub 2007 Aug 24. Biochemistry. 2007. PMID: 17718513
RNA-Templated Concatenation of Triplet Nucleic-Acid Probe.
Bahal R, Manna A, Hsieh WC, Thadke SA, Sureshkumar G, Ly DH. Bahal R, et al. Among authors: ly dh. Chembiochem. 2018 Apr 4;19(7):674-678. doi: 10.1002/cbic.201700574. Epub 2018 Feb 12. Chembiochem. 2018. PMID: 29323790
Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1.
Hsieh WC, Bahal R, Thadke SA, Bhatt K, Sobczak K, Thornton C, Ly DH. Hsieh WC, et al. Among authors: ly dh. Biochemistry. 2018 Feb 13;57(6):907-911. doi: 10.1021/acs.biochem.7b01239. Epub 2018 Jan 19. Biochemistry. 2018. PMID: 29334465 Free PMC article.
Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly.
Sacui I, Hsieh WC, Manna A, Sahu B, Ly DH. Sacui I, et al. Among authors: ly dh. J Am Chem Soc. 2015 Jul 8;137(26):8603-10. doi: 10.1021/jacs.5b04566. Epub 2015 Jun 29. J Am Chem Soc. 2015. PMID: 26079820
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