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Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.
Lyashchenko AK, Redd KJ, Yang J, Tibbs GR. Lyashchenko AK, et al. J Physiol. 2007 Aug 15;583(Pt 1):37-56. doi: 10.1113/jphysiol.2007.136465. Epub 2007 Jun 14. J Physiol. 2007. PMID: 17569731 Free PMC article.
cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.
Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR. Lyashchenko AK, et al. PLoS One. 2014 Jul 1;9(7):e101236. doi: 10.1371/journal.pone.0101236. eCollection 2014. PLoS One. 2014. PMID: 24983358 Free PMC article.
Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.
Lalancette-Hebert M, Sharma A, Lyashchenko AK, Shneider NA. Lalancette-Hebert M, et al. Among authors: lyashchenko ak. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8316-E8325. doi: 10.1073/pnas.1605210113. Epub 2016 Dec 7. Proc Natl Acad Sci U S A. 2016. PMID: 27930290 Free PMC article.
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function.
Sharma A, Lyashchenko AK, Lu L, Nasrabady SE, Elmaleh M, Mendelsohn M, Nemes A, Tapia JC, Mentis GZ, Shneider NA. Sharma A, et al. Among authors: lyashchenko ak. Nat Commun. 2016 Feb 4;7:10465. doi: 10.1038/ncomms10465. Nat Commun. 2016. PMID: 26842965 Free PMC article.
Quad Screen Test, A Multiplexed Biomarker Assay for Prenatal Screening to Assess Birth Defects: The Columbia University Experience Using the Beckman Access2 Immunoassay Analyzer and Benetech PRA.
Tecleab A, Lyashchenko AK, Rai AJ. Tecleab A, et al. Among authors: lyashchenko ak. Methods Mol Biol. 2019;1885:297-307. doi: 10.1007/978-1-4939-8889-1_20. Methods Mol Biol. 2019. PMID: 30506206
On precision dosing of oral small molecule drugs in oncology.
Lyashchenko AK, Cremers S. Lyashchenko AK, et al. Br J Clin Pharmacol. 2020 Jul 4. doi: 10.1111/bcp.14454. Online ahead of print. Br J Clin Pharmacol. 2020. PMID: 32621551 Review.
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