Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease.
Diagn Microbiol Infect Dis. 2013.
PMID: 23062467
Free PMC article.
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Lyme neuroborreliosis.
Curr Opin Infect Dis. 2019 Jun;32(3):259-264. doi: 10.1097/QCO.0000000000000545.
Curr Opin Infect Dis. 2019.
PMID: 30921086
Review.
PURPOSE OF REVIEW: To review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease. RECENT FINDINGS: Two-tier testing combining pairs of ELISAs, using C6 or VlsE assays to replace second tier Western blots, may …
PURPOSE OF REVIEW: To review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease. R …
Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease.
Diagn Microbiol Infect Dis. 2013 Jan;75(1):9-15. doi: 10.1016/j.diagmicrobio.2012.09.003. Epub 2012 Oct 11.
Diagn Microbiol Infect Dis. 2013.
PMID: 23062467
Free PMC article.
The C6 ELISA had sensitivity statistically comparable to 2-tier testing in sera from Lyme disease patients with early neurologic manifestations (88.6% versus 77.3%, P = 0.13) or arthritis (98.3% versus 95.6%, P = 0.38). ...In conclusion, using a refere …
The C6 ELISA had sensitivity statistically comparable to 2-tier testing in sera from Lyme disease patients with …
C6 peptide ELISA test in the serodiagnosis of Lyme borreliosis in Sweden.
Eur J Clin Microbiol Infect Dis. 2007 Jan;26(1):37-42. doi: 10.1007/s10096-006-0239-3.
Eur J Clin Microbiol Infect Dis. 2007.
PMID: 17180348
The aim of this study was to evaluate the synthetic C6 peptide test as a first-line test in a two-tiered scheme for Borrelia serology in a clinically well-characterized population of patients with Lyme borreliosis in Kalmar County, Sweden. ...The test panel c …
The aim of this study was to evaluate the synthetic C6 peptide test as a first-line test in a two-tiered scheme for Borrelia s …
Clinical performance and analytical accuracy of a C6 peptide-based point-of-care lateral flow immunoassay in Lyme borreliosis serology.
Diagn Microbiol Infect Dis. 2022 May;103(1):115657. doi: 10.1016/j.diagmicrobio.2022.115657. Epub 2022 Feb 3.
Diagn Microbiol Infect Dis. 2022.
PMID: 35228132
Free article.
We evaluated the analytical accuracy and the clinical performance of a ReaScan+ C6 LYME IgG point-of-care immunoassay (Reagena; index test). Analytical accuracy was evaluated in comparison to a C6 Lyme ELISA reference method (Oxford Immunotec) …
We evaluated the analytical accuracy and the clinical performance of a ReaScan+ C6 LYME IgG point-of-care immunoassay (Reagena …
High sensitivity and specificity of the C6-peptide ELISA on cerebrospinal fluid in Lyme neuroborreliosis patients.
Clin Microbiol Infect. 2011 Oct;17(10):1495-500. doi: 10.1111/j.1469-0691.2011.03459.x. Epub 2011 Mar 7.
Clin Microbiol Infect. 2011.
PMID: 21375653
Free article.
The C6-peptide ELISA is frequently used on serum but not on cerebrospinal fluid (CSF). Data on the sensitivity of the C6-peptide ELISA in CSF in patients suffering from LNB have been conflicting. ...The C6-peptide ELISA …
The C6-peptide ELISA is frequently used on serum but not on cerebrospinal fluid (CSF). Data on the sensitivity of the …
A novel single-tier serologic test to diagnose all stages of Lyme disease.
J Clin Microbiol. 2025 Sep 10;63(9):e0048325. doi: 10.1128/jcm.00483-25. Epub 2025 Aug 20.
J Clin Microbiol. 2025.
PMID: 40833084
Free PMC article.
Nevertheless, neither STTT nor MTTT is considered sensitive enough for diagnosing patients with erythema migrans, the most common clinical manifestation of early Lyme disease. We have developed a novel ELISA methodology termed "Hybrid Lyme ELISA …
Nevertheless, neither STTT nor MTTT is considered sensitive enough for diagnosing patients with erythema migrans, the most common clinical m …
Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE.
J Clin Microbiol. 1999 Dec;37(12):3990-6. doi: 10.1128/JCM.37.12.3990-3996.1999.
J Clin Microbiol. 1999.
PMID: 10565920
Free PMC article.
In the present study, the diagnostic performance of a peptide enzyme-linked immunosorbent assay (ELISA) based on a 26-mer synthetic peptide (C(6)) with the IR(6) sequence was explored. ...Four serum samples with very high anti-OspA …
In the present study, the diagnostic performance of a peptide enzyme-linked immunosorbent assay (ELISA …
Diagnosis of lyme borreliosis in europe.
Vector Borne Zoonotic Dis. 2003 Winter;3(4):215-27. doi: 10.1089/153036603322662200.
Vector Borne Zoonotic Dis. 2003.
PMID: 14733674
Review.
Thus microbiological diagnosis in European patients must consider the heterogeneity of Lyme disease borreliae for development of diagnostic tools such as PCR primers and diagnostic antigens. ...It also appears promising to use recombinant proteins (DbpA, VlsE, other …
Thus microbiological diagnosis in European patients must consider the heterogeneity of Lyme disease borreliae for development …
VlsE C6 peptide and IgG ELISA antibody analysis for clinical diagnosis of Lyme borreliosis in an endemic area.
Clin Microbiol Infect. 2006 May;12(5):496-7. doi: 10.1111/j.1469-0691.2006.01374.x.
Clin Microbiol Infect. 2006.
PMID: 16643532
Free article.
No abstract available.
Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates.
J Infect Dis. 2003 Apr 15;187(8):1187-99. doi: 10.1086/374395. Epub 2003 Apr 2.
J Infect Dis. 2003.
PMID: 12695997
Free PMC article.
In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorferi antigen VlsE1 (rVlsE1), IgG responses to a synthetic peptide homologous to a conserved internal sequence of VlsE (C6), and …
In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorf …
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