Cross-reactivity between Lyme and syphilis screening assays: Lyme disease does not cause false-positive syphilis screens.
Diagn Microbiol Infect Dis. 2016.
PMID: 26707064
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Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease.
Antibodies (Basel). 2023 Oct 5;12(4):63. doi: 10.3390/antib12040063.
Antibodies (Basel). 2023.
PMID: 37873860
Free PMC article.
Review.
Lyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. ...This approach was introduced due to the relatively high number of false-positive results obtained when using an ELISA alone. …
Lyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. .. …
Cross-reactivity between Lyme and syphilis screening assays: Lyme disease does not cause false-positive syphilis screens.
Diagn Microbiol Infect Dis. 2016 Mar;84(3):184-6. doi: 10.1016/j.diagmicrobio.2015.11.019. Epub 2015 Nov 23.
Diagn Microbiol Infect Dis. 2016.
PMID: 26707064
Increased rates of Lyme disease and syphilis in the same geographic area prompted an assessment of screening test cross-reactivity. This study supports the previously described cross-reactivity of Lyme screening among syphilis-p …
Increased rates of Lyme disease and syphilis in the same geographic area prompted an assessment of screening test cross …
False Positive Lyme Disease IgM Immunoblots in Children.
J Pediatr. 2016 Jul;174:267-269.e1. doi: 10.1016/j.jpeds.2016.04.004. Epub 2016 May 4.
J Pediatr. 2016.
PMID: 27157898
Free PMC article.
In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme diseas …
In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive …
Cross-reactivity in serological tests for Lyme disease and other spirochetal infections.
J Infect Dis. 1987 Jul;156(1):183-8. doi: 10.1093/infdis/156.1.183.
J Infect Dis. 1987.
PMID: 3298452
Strong cross-reactivity occurred when sera from individuals with Lyme disease, tick-borne relapsing fever, and louse-borne relapsing fever were tested against heterologous Borrelia antigens. Antibodies to Borrelia burgdorferi bound to Treponema pallidu …
Strong cross-reactivity occurred when sera from individuals with Lyme disease, tick-borne relapsing fever, and l …
Positive serology for Lyme disease borrelias in primary cutaneous B-cell lymphoma: a study in 22 patients; is it a fortuitous finding?
Hematol Oncol. 1999 Sep;17(3):107-16. doi: 10.1002/(sici)1099-1069(199909)17:3<107::aid-hon644>3.0.co;2-r.
Hematol Oncol. 1999.
PMID: 10641031
BACKGROUND: The historical association of acrodermatitis chronica atrophicans (ACA), now known to be a late manifestation of Lyme disease caused by Borrelia afzelii, with cutaneous lymphoma, and several small series of PCBCL with positive Lyme disea …
BACKGROUND: The historical association of acrodermatitis chronica atrophicans (ACA), now known to be a late manifestation of Lyme …
Cross-reactivity to Borrelia burgdorferi proteins in serum samples from residents of a tropical country nonendemic for Lyme disease.
J Infect Dis. 1997 Feb;175(2):466-9. doi: 10.1093/infdis/175.2.466.
J Infect Dis. 1997.
PMID: 9203675
Reports of Lyme disease from areas where the disease is not endemic have increased. Eighty-six human serum samples from Papua New Guinea (nonendemic for Lyme disease) were examined for the presence of IgG antibodies that recognize Borrelia burgd …
Reports of Lyme disease from areas where the disease is not endemic have increased. Eighty-six human serum samples from …
Guidelines for Lyme borreliosis: Diagnostic strategies.
Infect Dis Now. 2025 Dec;55(8S):105203. doi: 10.1016/j.idnow.2025.105203. Epub 2025 Nov 26.
Infect Dis Now. 2025.
PMID: 41314468
The diagnosis of Lyme borreliosis (LB) relies primarily on clinical evaluation supported by appropriate serologic testing in selected cases. ...Interpretation of serology must always consider clinical context: IgG may remain for years after recovery, and isolated IgM beyon …
The diagnosis of Lyme borreliosis (LB) relies primarily on clinical evaluation supported by appropriate serologic testing in selected …
False positive Lyme serology due to syphilis: report of 6 cases and review of the literature.
Acta Clin Belg. 2011 Jan-Feb;66(1):58-9. doi: 10.2143/ACB.66.1.2062517.
Acta Clin Belg. 2011.
PMID: 21485767
Review.
Western Blotting on serum and cerebrospinal fluid could not confirm the possible diagnosis of neuroborreliosis. VDRL and TPPA testing was positive, and finally, the diagnosis of neurosyphilis was established. We subsequently screened our database on patients with positi …
Western Blotting on serum and cerebrospinal fluid could not confirm the possible diagnosis of neuroborreliosis. VDRL and TPPA testing was …
Serologic diagnosis of Lyme disease.
Ann N Y Acad Sci. 1988;539:154-61. doi: 10.1111/j.1749-6632.1988.tb31848.x.
Ann N Y Acad Sci. 1988.
PMID: 3056197
Review.
During neuritis or arthritis, IgG antibody levels are usually elevated, and serologic verification is more easily achieved. Cross-reactivity occurs when sera from patients with Lyme disease, relapsing fever, or treponemal infections are screened agains …
During neuritis or arthritis, IgG antibody levels are usually elevated, and serologic verification is more easily achieved. Cross- …
Immunoserological Diagnosis of Human Borrelioses: Current Knowledge and Perspectives.
Front Cell Infect Microbiol. 2020 May 19;10:241. doi: 10.3389/fcimb.2020.00241. eCollection 2020.
Front Cell Infect Microbiol. 2020.
PMID: 32509603
Free PMC article.
Review.
However, emergence of the novel agent of relapsing fever B. miyamotoi has renewed interest in serology in this context. In Lyme disease, because direct detection methods show low sensitivity, serology plays a central role in the diagnostic strategy. ...The most freq …
However, emergence of the novel agent of relapsing fever B. miyamotoi has renewed interest in serology in this context. In Lyme di …
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