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Real-world Lyme disease testing results using modified vs standard two-tier test protocols.
Li Y, Chen Z, Tong CH, Van K, Jones RS, Bare LA. Li Y, et al. PLoS One. 2025 Jun 30;20(6):e0327376. doi: 10.1371/journal.pone.0327376. eCollection 2025. PLoS One. 2025. PMID: 40587524 Free PMC article.
The modified two-tier test (MTTT) and standard two-tier test (STTT) protocols are being used for Lyme disease serology testing in the clinic. ...To this end, we obtained results of Lyme disease testing performe …
The modified two-tier test (MTTT) and standard two-tier test (STTT) protocols are being used for Lyme …
Lyme neuroborreliosis.
Halperin JJ. Halperin JJ. Curr Opin Infect Dis. 2019 Jun;32(3):259-264. doi: 10.1097/QCO.0000000000000545. Curr Opin Infect Dis. 2019. PMID: 30921086 Review.
PURPOSE OF REVIEW: To review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease. RECENT FINDINGS: Two-tier testing combining pairs of ELISAs, using C6 or VlsE assays to replace second tier Western blot …
PURPOSE OF REVIEW: To review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease. R …
Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used.
Maulden AB, Garro AC, Balamuth F, Levas MN, Bennett JE, Neville DN, Branda JA, Nigrovic LE. Maulden AB, et al. J Pediatric Infect Dis Soc. 2020 Apr 30;9(2):128-133. doi: 10.1093/jpids/piy133. J Pediatric Infect Dis Soc. 2020. PMID: 30793167
In this study, we compared paired results of clinical 2-tier Lyme disease tests to those of the C6 peptide EIA followed by supplemental immunoblotting (C6 2-tier test). ...Of the 39 children with either a positive clinical or C6 2-tier test result alone, 2 ch …
In this study, we compared paired results of clinical 2-tier Lyme disease tests to those of the C6 peptide EIA followed …
Rapid single-tier serodiagnosis of Lyme disease.
Ghosh R, Joung HA, Goncharov A, Palanisamy B, Ngo K, Pejcinovic K, Krockenberger N, Horn EJ, Garner OB, Ghazal E, O'Kula A, Arnaboldi PM, Dattwyler RJ, Ozcan A, Di Carlo D. Ghosh R, et al. Nat Commun. 2024 Aug 20;15(1):7124. doi: 10.1038/s41467-024-51067-5. Nat Commun. 2024. PMID: 39164226 Free PMC article.
Here, we report a POC-compatible serologic test for Lyme disease (LD), leveraging synthetic peptides specific to LD antibodies and a paper-based platform for rapid, and cost-effective diagnosis. ...This LD diagnostic test could potentially replace the cumbersome …
Here, we report a POC-compatible serologic test for Lyme disease (LD), leveraging synthetic peptides specific to LD antibodies …
Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease.
Landry ML, Hassan S, Rottmann BG, Pesak SJ, Ordazzo M, Skrzyniarz M, Deponte S, Peaper DR. Landry ML, et al. J Clin Microbiol. 2024 May 8;62(5):e0013924. doi: 10.1128/jcm.00139-24. Epub 2024 Apr 10. J Clin Microbiol. 2024. PMID: 38597655 Free PMC article.
We compared the performance of a new modified two-tier testing (MTTT) platform, the Diasorin Liaison chemiluminescent immunoassay (CLIA), to the Zeus enzyme-linked immunoassay (ELISA) MTTT and to Zeus ELISA/Viramed immunoblot standard two-tier …
We compared the performance of a new modified two-tier testing (MTTT) platform, the Diasorin Liaison chemiluminescent i …
Single-tier point-of-care serodiagnosis of Lyme disease.
Ghosh R, Joung HA, Goncharov A, Palanisamy B, Ngo K, Pejcinovic K, Krockenberger N, Horn EJ, Garner OB, Ghazal E, O'Kula A, Arnaboldi PM, Dattwyler RJ, Ozcan A, Di Carlo D. Ghosh R, et al. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544508. doi: 10.1101/2023.06.14.544508. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 20;15(1):7124. doi: 10.1038/s41467-024-51067-5. PMID: 37398357 Free PMC article. Updated. Preprint.
Here, we report a POC serologic test for Lyme disease (LD), leveraging synthetic peptides tuned to be highly specific to the LD antibody repertoire across patients and compatible with a paper-based platform for rapid, reliable, and cost-effective diagnosis. ...This …
Here, we report a POC serologic test for Lyme disease (LD), leveraging synthetic peptides tuned to be highly specific to the L …
Diagnostic parameters of modified two-tier testing in European patients with early Lyme disease.
Baarsma ME, Schellekens J, Meijer BC, Brandenburg AH, Souilljee T, Hofhuis A, Hovius JW, van Dam AP. Baarsma ME, et al. Eur J Clin Microbiol Infect Dis. 2020 Nov;39(11):2143-2152. doi: 10.1007/s10096-020-03946-0. Epub 2020 Jul 6. Eur J Clin Microbiol Infect Dis. 2020. PMID: 32632699 Free PMC article.
Modified two-tier testing (MTTT) for Lyme borreliosis (i.e. confirmation with an EIA instead of an immunoblot) has been shown to have improved sensitivity compared with standard two-tier testing (STTT) in samples from American pati …
Modified two-tier testing (MTTT) for Lyme borreliosis (i.e. confirmation with an EIA instead of an immunoblot) h …
Evaluation of the Rapid Quidel Sofia 2 Lyme Immunoassay as a First-Tier Test in a Two-Tier Testing Algorithm for Lyme Disease: Comparison to the Zeus ELISA Borrelia VlsE1/pepC10 IgG/IgM Assay Followed by Immunoblot.
Lewandrowski EL, Branda JA, Lewandrowski K, Turbett S. Lewandrowski EL, et al. Am J Clin Pathol. 2023 Jul 5;160(1):58-61. doi: 10.1093/ajcp/aqad007. Am J Clin Pathol. 2023. PMID: 36881650 Free article.
OBJECTIVES: Two-tiered serologic testing for Lyme disease is usually performed using an enzyme-linked immunosorbent assay (ELISA) as the first-tier test. ...When the tests were followed by immunoblot in a two-tier algorithm, the agreement …
OBJECTIVES: Two-tiered serologic testing for Lyme disease is usually performed using an enzyme-linked immunosorbent ass …
Posttreatment Lyme disease syndrome.
Aucott JN. Aucott JN. Infect Dis Clin North Am. 2015 Jun;29(2):309-23. doi: 10.1016/j.idc.2015.02.012. Infect Dis Clin North Am. 2015. PMID: 25999226 Review.
The prognosis following appropriate antibiotic treatment of early or late Lyme disease is favorable but can be complicated by persistent symptoms of unknown cause termed posttreatment Lyme disease syndrome (PTLDS), characterized by fatigue, musculoskel …
The prognosis following appropriate antibiotic treatment of early or late Lyme disease is favorable but can be complicated by …
A novel single-tier serologic test to diagnose all stages of Lyme disease.
Levin AE, Wormser GP, Horn EJ, Karaseva N, Miller D, Kellogg H. Levin AE, et al. J Clin Microbiol. 2025 Sep 10;63(9):e0048325. doi: 10.1128/jcm.00483-25. Epub 2025 Aug 20. J Clin Microbiol. 2025. PMID: 40833084 Free PMC article.
Lyme disease, a bacterial zoonosis, is the most commonly reported vector-borne disease in the United States. ...This standard two-tier testing (STTT) approach provides high specificity, but at the cost of low sensitivity in early Lyme …
Lyme disease, a bacterial zoonosis, is the most commonly reported vector-borne disease in the United States. ...This st …
96 results