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151 results

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Page 1
Lyme borreliosis diagnosis: state of the art of improvements and innovations.
Guérin M, Shawky M, Zedan A, Octave S, Avalle B, Maffucci I, Padiolleau-Lefèvre S. Guérin M, et al. BMC Microbiol. 2023 Aug 1;23(1):204. doi: 10.1186/s12866-023-02935-5. BMC Microbiol. 2023. PMID: 37528399 Free PMC article. Review.
Above all, early detection of the disease raises some issues. Inappropriate diagnosis of Lyme borreliosis leads to therapeutic wandering, inducing potential chronic infection with a strong antibody response that fails to clear the infection. Early …
Above all, early detection of the disease raises some issues. Inappropriate diagnosis of Lyme borreliosis leads to therapeutic …
Diagnostic Testing for Lyme Disease.
Kobayashi T, Auwaerter PG. Kobayashi T, et al. Infect Dis Clin North Am. 2022 Sep;36(3):605-620. doi: 10.1016/j.idc.2022.04.001. Infect Dis Clin North Am. 2022. PMID: 36116838 Review.
Standard 2-tier testing (STTT), incorporating a screening enzyme immunoassay (EIA) or an immunofluorescence assay (IFA) that reflexes to IgM and IgG immunoblots, has been the primary diagnostic test for Lyme disease since 1995. In 2019, the Food and Drug Administration app …
Standard 2-tier testing (STTT), incorporating a screening enzyme immunoassay (EIA) or an immunofluorescence assay (IFA) that reflexes to IgM …
Serum Epitope Repertoire Analysis Enables Early Detection of Lyme Disease with Improved Sensitivity in an Expandable Multiplex Format.
Reifert J, Kamath K, Bozekowski J, Lis E, Horn EJ, Granger D, Theel ES, Shon J, Sawyer JR, Daugherty PS. Reifert J, et al. J Clin Microbiol. 2021 Jan 21;59(2):e01836-20. doi: 10.1128/JCM.01836-20. Print 2021 Jan 21. J Clin Microbiol. 2021. PMID: 33148704 Free PMC article.
Widely employed diagnostic antibody serology for Lyme disease, known as standard two-tier testing (STTT), exhibits insufficient sensitivity in early Lyme disease, yielding many thousands of false-negative test results each year. Given this probl …
Widely employed diagnostic antibody serology for Lyme disease, known as standard two-tier testing (STTT), exhibits insufficien …
Clinical evaluation of a Borrelia modified two-tiered testing (MTTT) shows increased early sensitivity for Borrelia burgdorferi but not other endemic Borrelia species in a high incidence region for Lyme disease in Wisconsin.
Sabin AP, Scholze BP, Lovrich SD, Callister SM. Sabin AP, et al. Diagn Microbiol Infect Dis. 2023 Jan;105(1):115837. doi: 10.1016/j.diagmicrobio.2022.115837. Epub 2022 Oct 17. Diagn Microbiol Infect Dis. 2023. PMID: 36370542
The MTTT confirmed the illness in 116 subjects (36%, P = 0.007), and 30 (26%) were negative by the STTT. Increased MTTT sensitivity was seen (P = 0.0005) during early infection. MTTT was insufficiently sensitive to identify other non-Borrelia spp. i …
The MTTT confirmed the illness in 116 subjects (36%, P = 0.007), and 30 (26%) were negative by the STTT. Increased MTTT sensitivity w …
Guidelines for Lyme borreliosis: Diagnostic strategies.
Jaulhac B, Bouiller K, Lenormand C, Baux E, Sevestre J, Gautier A, Sobas C, Raffetin A. Jaulhac B, et al. Infect Dis Now. 2025 Dec;55(8S):105203. doi: 10.1016/j.idnow.2025.105203. Epub 2025 Nov 26. Infect Dis Now. 2025. PMID: 41314468
The diagnosis of Lyme borreliosis (LB) relies primarily on clinical evaluation supported by appropriate serologic testing in selected cases. ...Serologic limitations include low sensitivity in early disease and cross-reactivity, particularly for …
The diagnosis of Lyme borreliosis (LB) relies primarily on clinical evaluation supported by appropriate serologic testing in s …
Early disseminated Lyme disease: Lyme meningitis.
Pachner AR. Pachner AR. Am J Med. 1995 Apr 24;98(4A):30S-37S; discussion 37S-43S. doi: 10.1016/s0002-9343(99)80042-4. Am J Med. 1995. PMID: 7726190 Review.
Occurring within the first few months of infection, it initially presents as a chronic basilar meningitis. Much about the pathogenesis of Lyme meningitis has been learned from animal models, the best being the adult Rhesus macaque. ...Culture is not generally useful …
Occurring within the first few months of infection, it initially presents as a chronic basilar meningitis. Much about the pathogenesi …
Evaluation of Selected Borrelia burgdorferi lp54 Plasmid-Encoded Gene Products Expressed during Mammalian Infection as Antigens To Improve Serodiagnostic Testing for Early Lyme Disease.
Weiner ZP, Crew RM, Brandt KS, Ullmann AJ, Schriefer ME, Molins CR, Gilmore RD. Weiner ZP, et al. Clin Vaccine Immunol. 2015 Nov;22(11):1176-86. doi: 10.1128/CVI.00399-15. Epub 2015 Sep 16. Clin Vaccine Immunol. 2015. PMID: 26376927 Free PMC article.
Laboratory testing for the diagnosis of Lyme disease is performed primarily by serologic assays and is accurate for detection beyond the acute stage of the infection. Serodiagnostic assays to detect the early stages of infection, however, are li …
Laboratory testing for the diagnosis of Lyme disease is performed primarily by serologic assays and is accurate for detection …
Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease.
Lahey LJ, Panas MW, Mao R, Delanoy M, Flanagan JJ, Binder SR, Rebman AW, Montoya JG, Soloski MJ, Steere AC, Dattwyler RJ, Arnaboldi PM, Aucott JN, Robinson WH. Lahey LJ, et al. J Clin Microbiol. 2015 Dec;53(12):3834-41. doi: 10.1128/JCM.02111-15. Epub 2015 Oct 7. J Clin Microbiol. 2015. PMID: 26447113 Free PMC article.
The Centers for Disease Control and Prevention recommends a two-tiered testing algorithm; however, this scheme has limited sensitivity for detecting early Lyme disease. Thus, there is a need to improve diagnostics for Lyme disease at the early s …
The Centers for Disease Control and Prevention recommends a two-tiered testing algorithm; however, this scheme has limited sensitivity …
A novel single-tier serologic test to diagnose all stages of Lyme disease.
Levin AE, Wormser GP, Horn EJ, Karaseva N, Miller D, Kellogg H. Levin AE, et al. J Clin Microbiol. 2025 Sep 10;63(9):e0048325. doi: 10.1128/jcm.00483-25. Epub 2025 Aug 20. J Clin Microbiol. 2025. PMID: 40833084 Free PMC article.
This standard two-tier testing (STTT) approach provides high specificity, but at the cost of low sensitivity in early Lyme disease. Recent studies have shown that a modified two-tier (MTTT) testing approach, in which a second ELISA replaces the immunob …
This standard two-tier testing (STTT) approach provides high specificity, but at the cost of low sensitivity in early …
Recent strategies for the diagnosis of early Lyme disease.
Chou E, Lin YP, Cady NC. Chou E, et al. Sci Prog. 2018 Oct 1;101(4):311-331. doi: 10.3184/003685018X15360040523730. Epub 2018 Oct 8. Sci Prog. 2018. PMID: 30296967 Free PMC article. Review.
Lyme disease (LD) is the most common tick-borne disease in the Northern Hemisphere. As the most prevalent vector-borne disease in the USA, LD affects 300,000 human cases each year. ...These assays detect host antibodies against the bacteria, but are hampered by low sens …
Lyme disease (LD) is the most common tick-borne disease in the Northern Hemisphere. As the most prevalent vector-borne disease in the …
151 results