Lynagh T - Search Results

1

Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel.

Callau-Vázquez D, Pless SA, Lynagh T. Callau-Vázquez D, et al. Among authors: lynagh t. Biochemistry. 2018 Feb 27;57(8):1360-1368. doi: 10.1021/acs.biochem.7b01245. Epub 2018 Feb 7. Biochemistry. 2018. PMID: 29411605

2

Principles of agonist recognition in Cys-loop receptors.

Lynagh T, Pless SA. Lynagh T, et al. Front Physiol. 2014 Apr 24;5:160. doi: 10.3389/fphys.2014.00160. eCollection 2014. Front Physiol. 2014. PMID: 24795655 Free PMC article. Review.

3

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.

Lynagh T, Beech RN, Lalande MJ, Keller K, Cromer BA, Wolstenholme AJ, Laube B. Lynagh T, et al. Sci Rep. 2015 Feb 24;5:8558. doi: 10.1038/srep08558. Sci Rep. 2015. PMID: 25708000 Free PMC article.

4

Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

Braun N, Lynagh T, Yu R, Biggin PC, Pless SA. Braun N, et al. Among authors: lynagh t. ACS Chem Neurosci. 2016 Mar 16;7(3):339-48. doi: 10.1021/acschemneuro.5b00298. Epub 2016 Jan 29. ACS Chem Neurosci. 2016. PMID: 26764897

5

Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel.

Lynagh T, Komnatnyy VV, Pless SA. Lynagh T, et al. J Biol Chem. 2017 Mar 3;292(9):3940-3946. doi: 10.1074/jbc.M116.772939. Epub 2017 Jan 17. J Biol Chem. 2017. PMID: 28096462 Free PMC article.

6

A selectivity filter at the intracellular end of the acid-sensing ion channel pore.

Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy VV, Colding JM, Allen TW, Pless SA. Lynagh T, et al. Elife. 2017 May 12;6:e24630. doi: 10.7554/eLife.24630. Elife. 2017. PMID: 28498103 Free PMC article.

7

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.

Lynagh T, Romero-Rojo JL, Lund C, Pless SA. Lynagh T, et al. J Med Chem. 2017 Oct 12;60(19):8192-8200. doi: 10.1021/acs.jmedchem.7b01072. Epub 2017 Sep 26. J Med Chem. 2017. PMID: 28949138

8

Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes.

Lynagh T, Mikhaleva Y, Colding JM, Glover JC, Pless SA. Lynagh T, et al. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8430-8435. doi: 10.1073/pnas.1806614115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061402 Free PMC article.

9

Mechanism and site of action of big dynorphin on ASIC1a.

Borg CB, Braun N, Heusser SA, Bay Y, Weis D, Galleano I, Lund C, Tian W, Haugaard-Kedström LM, Bennett EP, Lynagh T, Strømgaard K, Andersen J, Pless SA. Borg CB, et al. Among authors: lynagh t. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7447-7454. doi: 10.1073/pnas.1919323117. Epub 2020 Mar 12. Proc Natl Acad Sci U S A. 2020. PMID: 32165542 Free PMC article.

10

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.

Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B. Lynagh T, et al. J Med Chem. 2020 Nov 25;63(22):13709-13718. doi: 10.1021/acs.jmedchem.0c01202. Epub 2020 Nov 3. J Med Chem. 2020. PMID: 33143415 Free PMC article.

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