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Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors.
Andersen JN, Sathyanarayanan S, Di Bacco A, Chi A, Zhang T, Chen AH, Dolinski B, Kraus M, Roberts B, Arthur W, Klinghoffer RA, Gargano D, Li L, Feldman I, Lynch B, Rush J, Hendrickson RC, Blume-Jensen P, Paweletz CP. Andersen JN, et al. Among authors: lynch b. Sci Transl Med. 2010 Aug 4;2(43):43ra55. doi: 10.1126/scitranslmed.3001065. Sci Transl Med. 2010. PMID: 20686178
A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors.
Loboda A, Nebozhyn M, Klinghoffer R, Frazier J, Chastain M, Arthur W, Roberts B, Zhang T, Chenard M, Haines B, Andersen J, Nagashima K, Paweletz C, Lynch B, Feldman I, Dai H, Huang P, Watters J. Loboda A, et al. Among authors: lynch b. BMC Med Genomics. 2010 Jun 30;3:26. doi: 10.1186/1755-8794-3-26. BMC Med Genomics. 2010. PMID: 20591134 Free PMC article.
Response to letter from Geoffrey W. Stuart.
Ellis L, Milne RL, Moore MM, Bigby KJ, Sinclair C, Brenner DR, Moore SC, Matthews CE, Bassett JK, Lynch BM. Ellis L, et al. Among authors: lynch bm. J Sci Med Sport. 2024 Apr 4:S1440-2440(24)00113-0. doi: 10.1016/j.jsams.2024.04.001. Online ahead of print. J Sci Med Sport. 2024. PMID: 38614843 No abstract available.
Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen.
Ferreira RC, Reynolds SJ, Capoferri AA, Baker OR, Brown EE, Klock E, Miller J, Lai J, Saraf S, Kirby C, Lynch B, Hackman J, Gowanlock SN, Tomusange S, Jamiru S, Anok A, Kityamuweesi T, Buule P, Bruno D, Martens C, Rose R, Lamers SL, Galiwango RM, Poon AFY, Quinn TC, Prodger JL, Redd AD. Ferreira RC, et al. Among authors: lynch b. EBioMedicine. 2024 Apr;102:105040. doi: 10.1016/j.ebiom.2024.105040. Epub 2024 Mar 13. EBioMedicine. 2024. PMID: 38485563 Free PMC article.
Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer.
Laskar RS, Qu C, Huyghe JR, Harrison T, Hayes RB, Cao Y, Campbell PT, Steinfelder R, Talukdar FR, Brenner H, Ogino S, Brendt S, Bishop DT, Buchanan DD, Chan AT, Cotterchio M, Gruber SB, Gsur A, van Guelpen B, Jenkins MA, Keku TO, Lynch BM, Le Marchand L, Martin RM, McCarthy K, Moreno V, Pearlman R, Song M, Tsilidis KK, Vodička P, Woods MO, Wu K, Hsu L, Gunter MJ, Peters U, Murphy N; Colorectal Transdisciplinary (CORECT) Study, the Colon Cancer Family Registry (CCFR), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Laskar RS, et al. Among authors: lynch bm. Ann Oncol. 2024 Feb 24:S0923-7534(24)00058-9. doi: 10.1016/j.annonc.2024.02.008. Online ahead of print. Ann Oncol. 2024. PMID: 38408508 Free article.
663 results