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Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid.
Martin DS, Lonergan PE, Boland B, Fogarty MP, Brady M, Horrobin DF, Campbell VA, Lynch MA. Martin DS, et al. J Biol Chem. 2002 Sep 13;277(37):34239-46. doi: 10.1074/jbc.M205289200. Epub 2002 Jun 28. J Biol Chem. 2002. PMID: 12091394
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus.
Kelly A, Vereker E, Nolan Y, Brady M, Barry C, Loscher CE, Mills KH, Lynch MA. Kelly A, et al. J Biol Chem. 2003 May 23;278(21):19453-62. doi: 10.1074/jbc.M301938200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12609991
IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity.
Armstrong ME, Loscher CE, Lynch MA, Mills KH. Armstrong ME, et al. J Neuroimmunol. 2003 Mar;136(1-2):25-33. doi: 10.1016/s0165-5728(02)00468-x. J Neuroimmunol. 2003. PMID: 12620640
Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?
Minogue AM, Schmid AW, Fogarty MP, Moore AC, Campbell VA, Herron CE, Lynch MA. Minogue AM, et al. J Biol Chem. 2003 Jul 25;278(30):27971-80. doi: 10.1074/jbc.M302530200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12738769
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