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Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency.
Roos A, Garred P, Wildenberg ME, Lynch NJ, Munoz JR, Zuiverloon TC, Bouwman LH, Schlagwein N, Fallaux van den Houten FC, Faber-Krol MC, Madsen HO, Schwaeble WJ, Matsushita M, Fujita T, Daha MR. Roos A, et al. Among authors: lynch nj. Eur J Immunol. 2004 Sep;34(9):2589-98. doi: 10.1002/eji.200324401. Eur J Immunol. 2004. PMID: 15307191 Free article.
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
Stover C, Endo Y, Takahashi M, Lynch NJ, Constantinescu C, Vorup-Jensen T, Thiel S, Friedl H, Hankeln T, Hall R, Gregory S, Fujita T, Schwaeble W. Stover C, et al. Among authors: lynch nj. Genes Immun. 2001 May;2(3):119-27. doi: 10.1038/sj.gene.6363745. Genes Immun. 2001. PMID: 11426320
51 results