Lynch RJ - Search Results

1

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: lynch rj. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

2

Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.

Ashton WT, Cantone CL, Tolman RL, Greenlee WJ, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: lynch rj. J Med Chem. 1992 Jul 24;35(15):2772-81. doi: 10.1021/jm00093a009. J Med Chem. 1992. PMID: 1495010

3

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.

de Laszlo SE, Bush BL, Doyle JJ, Greenlee WJ, Hangauer DG, Halgren TA, Lynch RJ, Schorn TW, Siegl PK. de Laszlo SE, et al. Among authors: lynch rj. J Med Chem. 1992 Mar 6;35(5):833-46. doi: 10.1021/jm00083a006. J Med Chem. 1992. PMID: 1548675

4

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Weber AE, Halgren TA, Doyle JJ, Lynch RJ, Siegl PK, Parsons WH, Greenlee WJ, Patchett AA. Weber AE, et al. Among authors: lynch rj. J Med Chem. 1991 Sep;34(9):2692-701. doi: 10.1021/jm00113a005. J Med Chem. 1991. PMID: 1895289

5

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.

Williams PD, Perlow DS, Payne LS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: lynch rj. J Med Chem. 1991 Mar;34(3):887-900. doi: 10.1021/jm00107a004. J Med Chem. 1991. PMID: 2002469

6

Design of renin inhibitors containing conformationally restricted mimetics of the P1-P1' and P1 through P2' sites.

Williams PD, Payne LS, Perlow DS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: lynch rj. Adv Exp Med Biol. 1991;306:325-34. doi: 10.1007/978-1-4684-6012-4_38. Adv Exp Med Biol. 1991. PMID: 1812722 No abstract available.

7

Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Boger J, Poe M, LaMont BI, Lynch RJ, Ulm EH, Vlasuk GP, et al. Bock MG, et al. Among authors: lynch rj. J Med Chem. 1987 Oct;30(10):1853-7. doi: 10.1021/jm00393a029. J Med Chem. 1987. PMID: 3309316

8

Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.

Hutchinson JH, Cook JJ, Brashear KM, Breslin MJ, Glass JD, Gould RJ, Halczenko W, Holahan MA, Lynch RJ, Sitko GR, Stranieri MT, Hartman GD. Hutchinson JH, et al. Among authors: lynch rj. J Med Chem. 1996 Nov 8;39(23):4583-91. doi: 10.1021/jm9604787. J Med Chem. 1996. PMID: 8917647

9

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors.

Hartman GD, Egbertson MS, Halczenko W, Laswell WL, Duggan ME, Smith RL, Naylor AM, Manno PD, Lynch RJ, Zhang G, et al. Hartman GD, et al. Among authors: lynch rj. J Med Chem. 1992 Nov 27;35(24):4640-2. doi: 10.1021/jm00102a020. J Med Chem. 1992. PMID: 1469694 No abstract available.

10

Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.

Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ Jr, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD. Askew BC, et al. Among authors: lynch jj jr, lynch rj. J Med Chem. 1997 Jun 6;40(12):1779-88. doi: 10.1021/jm9608117. J Med Chem. 1997. PMID: 9191954

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