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Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands.
Moriwaki Y, Yoshikawa K, Fukuda H, Fujii YX, Misawa H, Kawashima K. Moriwaki Y, et al. Life Sci. 2007 May 30;80(24-25):2365-8. doi: 10.1016/j.lfs.2006.12.028. Epub 2007 Jan 16. Life Sci. 2007. PMID: 17286989
A novel transduction pathway via which apoptosis of keratinocytes is regulated through nicotinic acetylcholine (ACh) receptors (nAChRs) has emerged in studies of secreted mammalian Ly6/urokinase plasminogen-type activator receptor-related protein-1 and-2 (SLURP-1 an …
A novel transduction pathway via which apoptosis of keratinocytes is regulated through nicotinic acetylcholine (ACh) receptors (nAChR …
Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors.
Lyukmanova EN, Bychkov ML, Sharonov GV, Efremenko AV, Shulepko MA, Kulbatskii DS, Shenkarev ZO, Feofanov AV, Dolgikh DA, Kirpichnikov MP. Lyukmanova EN, et al. Br J Pharmacol. 2018 Jun;175(11):1973-1986. doi: 10.1111/bph.14194. Epub 2018 Apr 24. Br J Pharmacol. 2018. PMID: 29505672 Free PMC article.
Secretion of endogenous SLURP-1 by A431 cells under treatment with recombinant SLURP-1 was analysed by Western-blotting. ...Proliferation of A549 cells was inhibited only by SLURP-1. The anti-proliferative activity of SLURPs on A431 cells was associate …
Secretion of endogenous SLURP-1 by A431 cells under treatment with recombinant SLURP-1 was analysed by Western-blotting. ...Pr …
Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Lyukmanova EN, Shulepko MA, Shenkarev ZO, Bychkov ML, Paramonov AS, Chugunov AO, Kulbatskii DS, Arvaniti M, Dolejsi E, Schaer T, Arseniev AS, Efremov RG, Thomsen MS, Dolezal V, Bertrand D, Dolgikh DA, Kirpichnikov MP. Lyukmanova EN, et al. Sci Rep. 2016 Aug 3;6:30698. doi: 10.1038/srep30698. Sci Rep. 2016. PMID: 27485575 Free PMC article.
Human-secreted Ly-6/uPAR-related protein-2 (SLURP-2) regulates the growth and differentiation of epithelial cells. Previously, the auto/paracrine activity of SLURP-2 was considered to be mediated via its interaction with the alpha3beta2 subtype of the nicotinic …
Human-secreted Ly-6/uPAR-related protein-2 (SLURP-2) regulates the growth and differentiation of epithelial cells. Previously, the au …
Selective targeting of alpha7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo.
Shlepova OV, Shulepko MA, Shipunova VO, Bychkov ML, Kukushkin ID, Chulina IA, Azev VN, Shramova EI, Kazakov VA, Ismailova AM, Palikova YA, Palikov VA, Kalabina EA, Shaykhutdinova EA, Slashcheva GA, Tukhovskaya EA, Dyachenko IA, Murashev AN, Deyev SM, Kirpichnikov MP, Shenkarev ZO, Lyukmanova EN. Shlepova OV, et al. Front Cell Dev Biol. 2023 Oct 3;11:1256716. doi: 10.3389/fcell.2023.1256716. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37854069 Free PMC article.
alpha7-Type nicotinic acetylcholine receptor (alpha7-nAChR) promotes the growth and metastasis of solid tumors. ...Here, we investigated mechanisms of antiproliferative activity of recombinant SLURP-1 in epidermoid carcinoma A431 cells and activity of SLURP-1 …
alpha7-Type nicotinic acetylcholine receptor (alpha7-nAChR) promotes the growth and metastasis of solid tumors. ...Here, we investiga …
Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of alpha7 Nicotinic Acetylcholine Receptor.
Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP. Lyukmanova EN, et al. PLoS One. 2016 Feb 23;11(2):e0149733. doi: 10.1371/journal.pone.0149733. eCollection 2016. PLoS One. 2016. PMID: 26905431 Free PMC article.
SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. ...These findings imply an allosteric antagonist-like mode of SLURP-1 interaction with alpha7-nAChRs outside the classical ligand-binding site. Contrary to rSLU …
SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. ...These findings imply an …
Three-finger proteins from snakes and humans acting on nicotinic receptors: Old and new.
Tsetlin VI, Kasheverov IE, Utkin YN. Tsetlin VI, et al. J Neurochem. 2021 Sep;158(6):1223-1235. doi: 10.1111/jnc.15123. Epub 2020 Jul 26. J Neurochem. 2021. PMID: 32648941 Review.
The first toxin to give rise to the three-finger protein (TFP) family was alpha-bungarotoxin (alpha-Bgt) from Bungarus multicinctus krait venom. alpha-Bgt was crucial for research on nicotinic acetylcholine receptors (nAChRs), and in this Review article we focus on present …
The first toxin to give rise to the three-finger protein (TFP) family was alpha-bungarotoxin (alpha-Bgt) from Bungarus multicinctus krait ve …
SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium.
Arredondo J, Chernyavsky AI, Jolkovsky DL, Webber RJ, Grando SA. Arredondo J, et al. J Cell Physiol. 2006 Jul;208(1):238-45. doi: 10.1002/jcp.20661. J Cell Physiol. 2006. PMID: 16575903
Previous studies demonstrated that SLURP-1 activates the alpha7 subtype of keratinocyte nicotinic acetylcholine receptors (nAChRs) and facilitates keratinization and programmed cell death, and that the level of SLURP-2 was found to be upregulated several fold …
Previous studies demonstrated that SLURP-1 activates the alpha7 subtype of keratinocyte nicotinic acetylcholine receptors (nAC …
Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer.
Pettersson A, Nordlander S, Nylund G, Khorram-Manesh A, Nordgren S, Delbro DS. Pettersson A, et al. Auton Autacoid Pharmacol. 2008 Oct;28(4):109-16. doi: 10.1111/j.1474-8673.2008.00424.x. Epub 2008 Aug 20. Auton Autacoid Pharmacol. 2008. PMID: 18764860
Secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is a recently discovered endogenous ligand at the alpha7 subunit of the nicotinic acetylcholine receptors. Previous reports have shown that SLURP-1 is expressed in no …
Secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is a recently discovered endogenous liga …
Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium.
Fu XW, Song PF, Spindel ER. Fu XW, et al. Int Immunopharmacol. 2015 Nov;29(1):93-8. doi: 10.1016/j.intimp.2015.05.022. Epub 2015 May 26. Int Immunopharmacol. 2015. PMID: 26025503 Free PMC article.
Multiple members of the ly-6 protein family can modulate nicotinic signaling including lynx1, lynx2, slurp-1, slurp-2 and prostate stem cell antigen (PSCA). Consistent with the expression of multiple nicotinic receptors in bronchial epithelium, …
Multiple members of the ly-6 protein family can modulate nicotinic signaling including lynx1, lynx2, slurp-1, slurp …
Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.
Moriwaki Y, Takada K, Tsuji S, Kawashima K, Misawa H. Moriwaki Y, et al. Int Immunopharmacol. 2015 Nov;29(1):71-5. doi: 10.1016/j.intimp.2015.05.030. Epub 2015 May 29. Int Immunopharmacol. 2015. PMID: 26033490
Additionally, a particular hybrid transcript, LYNX1-SLURP2, which contains both LYNX1 and SLURP-2 sequences, with unknown function, has been reported. ...To better understand the function of nAChRs in keratinocytes, we investigated the expression profiles of …
Additionally, a particular hybrid transcript, LYNX1-SLURP2, which contains both LYNX1 and SLURP-2 sequences, with unkno …
23 results