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Transposition of Tn4451 and Tn4453 involves a circular intermediate that forms a promoter for the large resolvase, TnpX.
Lyras D, Rood JI. Lyras D, et al. Mol Microbiol. 2000 Nov;38(3):588-601. doi: 10.1046/j.1365-2958.2000.02154.x. Mol Microbiol. 2000. PMID: 11069682
Repurposing auranofin as a Clostridioides difficile therapeutic.
Hutton ML, Pehlivanoglu H, Vidor CJ, James ML, Thomson MJ, Lyras D. Hutton ML, et al. Among authors: lyras d. J Antimicrob Chemother. 2020 Feb 1;75(2):409-417. doi: 10.1093/jac/dkz430. J Antimicrob Chemother. 2020. PMID: 31642901
Characterization of a Tra 2 function of RP1 that affects growth of Pseudomonas aeruginosa PAO and surface exclusion in Escherichia coli K12.
Lyras D, Palombo EA, Stanisich VA. Lyras D, et al. Plasmid. 1992 Mar;27(2):105-18. doi: 10.1016/0147-619x(92)90011-x. Plasmid. 1992. PMID: 1319592
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.
Sloan J, McMurry LM, Lyras D, Levy SB, Rood JI. Sloan J, et al. Among authors: lyras d. Mol Microbiol. 1994 Jan;11(2):403-15. doi: 10.1111/j.1365-2958.1994.tb00320.x. Mol Microbiol. 1994. PMID: 8170402
Genetic organization and distribution of tetracycline resistance determinants in Clostridium perfringens.
Lyras D, Rood JI. Lyras D, et al. Antimicrob Agents Chemother. 1996 Nov;40(11):2500-4. doi: 10.1128/AAC.40.11.2500. Antimicrob Agents Chemother. 1996. PMID: 8913453 Free PMC article.
McMurry, D. Lyras, S. B. Levy, and J. I. Rood, Mol. Microbiol. 11:403-415, 1994). In the present study, hybridization and PCR analysis of 81 tetracycline-resistant isolates of C. perfringens showed that they all carried the tetA(P) gene. ...
McMurry, D. Lyras, S. B. Levy, and J. I. Rood, Mol. Microbiol. 11:403-415, 1994). In the present study, hybridization and PCR …
Conjugative transfer of RP4-oriT shuttle vectors from Escherichia coli to Clostridium perfringens.
Lyras D, Rood JI. Lyras D, et al. Plasmid. 1998;39(2):160-4. doi: 10.1006/plas.1997.1325. Plasmid. 1998. PMID: 9514706
Chloramphenicol resistance in Clostridium difficile is encoded on Tn4453 transposons that are closely related to Tn4451 from Clostridium perfringens.
Lyras D, Storie C, Huggins AS, Crellin PK, Bannam TL, Rood JI. Lyras D, et al. Antimicrob Agents Chemother. 1998 Jul;42(7):1563-7. doi: 10.1128/AAC.42.7.1563. Antimicrob Agents Chemother. 1998. PMID: 9660983 Free PMC article.
The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes.
Farrow KA, Lyras D, Rood JI. Farrow KA, et al. Among authors: lyras d. Antimicrob Agents Chemother. 2000 Feb;44(2):411-3. doi: 10.1128/aac.44.2.411-413.2000. Antimicrob Agents Chemother. 2000. PMID: 10639372 Free PMC article.
Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX.
Wang H, Roberts AP, Lyras D, Rood JI, Wilks M, Mullany P. Wang H, et al. Among authors: lyras d. J Bacteriol. 2000 Jul;182(13):3775-83. doi: 10.1128/jb.182.13.3775-3783.2000. J Bacteriol. 2000. PMID: 10850994 Free PMC article.
Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules.
Roberts AP, Johanesen PA, Lyras D, Mullany P, Rood JI. Roberts AP, et al. Among authors: lyras d. Microbiology (Reading). 2001 May;147(Pt 5):1243-1251. doi: 10.1099/00221287-147-5-1243. Microbiology (Reading). 2001. PMID: 11320127
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